May 20, 2021
Frozen storage and shipping in biopharma with RoSSReading time: 3 minutes
Drug substances are precious and sensitive goods that not only require careful handling but also reliable protection throughout the entire logistics process. In order to allow for both, the liquid substances are frozen for shipping and storage in specialized containers that keep them safe throughout the journey. Single Use Suppport’s RoSS (robust shell system for frozen storage and shipping), composed of an outer sleeve of robust stainless-steel and an adaptive inner layer of 3D foam, contributes to a safe journey. It warrants the single-use bag’s intact arrival at its final destination, keeping its precious contents protected from biocontamination and other damages.
The highly flexible and scalable nature of the single use components used for the construction of RoSS makes handling very easy and user-friendly, while acquisition and storage costs as well as space requirements can be reduced significantly. As a result, cold chain logistics processes based on advanced single use technologies offer reliable, safe and controlled handling of biopharmaceutical liquids, which are not only highly valuable but also very sensitive.
Flexible, versatile and user-friendly protection for single-use bags
With the varying requirements of the biopharmaceutical industry, of labs and manufacturers in mind, RoSS has been designed to offer flexible, versatile and user-friendly protection for single-use bags of any size and brand. It is both bag-agnostic and scalable, protecting filled bags of any given manufacturer and volume.
The outer shell: Robust stainless steel
Thanks to its thermal diffusivity, the stainless-steel used for the outer shell is not only acting as a protective buffer but also offers the best possible temperature transfer from freezer to bag to liquid. As a result of the direct contact between the plate freezer and the stainless steel plates covering the container, the substance contained in RoSS® is evenly frozen. The close contact between freezing plates and liquid substance significantly speeds up the process by facilitating a direct transfer of the cold.
The interior: 3D foam for added protection
While the outer shell is made of robust stainless steel, specialized foam on the inside adds further stabilization. Single-use bag and content are shielded by a layer of soft 3D foam that adapts to the bag’s shape during the freezing process, eventually fully immobilizing it. The design leaves space for tubings to make handling a breeze.
In short: Taking inspiration from an oyster, RoSS combines stainless steel on the outside and protective foam on the inside to make for the perfect robust and compact protection of your valuable goods during shipping and storage:
- RoSS is independent from any single-use bag manufacturer, protecting what’s valuable in your single use bag of choice.
- RoSS is scalable to different volumes to cater for both lab and production environments.
- RoSS ist the scalable as flexible choice for frozen storage and shipping single use bags (of different suppliers) in biopharma
As an added benefit, there is no ambient air that requires cooling, as is the case when utilizing traditional freezers. The homogenous outcome when employing plate freezers not only maintains the substance’s original quality but also protects it from potential damages during shipping and thawing.
The shell is tamper-proof so the bag contained within cannot be accessed during the entire controlled freezing and logistics process.
RoSS freeze thaw platform for frozen storage and shipping
While RoSS shells are ideal when it comes to the overall protection of frozen drug substances, they form only one part of the state-of-the-art RoSS freeze thaw system, which in itself offers a number of benefits for pharmaceutical labs and production sites. As a main selling point, it helps to avoid human failure in the handling of drug substances as it offers a process that is fully controlled and monitored from beginning to end. In addition, it can be adapted and scaled to meet any requirements and needs, thanks to the utilization of single-use components. Like this, the RoSS freeze thaw platform furthermore
- significantly reduces the need for cleaning and sterilization
- minimizes production costs
- maximizes production output
- is easy and simple to dispose of
- reduces power and water consumption
- minimum storage space
- optimized for frozen storage and shipping
Simply put: Using RoSS means optimizing your process by significantly reducing risks and the potential for human error.