The One Process for Small Volumes in Biopharma

Our single-use technologies and sterile consumables come with the flexibility required for fast turnaround times in advanced therapeutic approches & thehandling of small volumes down to 1mL.This includes the areas of aliquotation & filtration, controlled freezing & thawing and all required logistic steps.

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Why is this process the one for you?

  • The Accurate One

    Fill and freeze your products with the highest accuracy. With a filling accuracy of less than +/- 1mL and reproducible freezing recipes for your optimal result.

  • The Flexible One

    Independent from type, manufacturer and size of your single-use bag, the modular platforms and single-use technologies will meet your requirements.

  • The Secure One

    Automated aseptic filling at highest accuracy minimizes both operational human errors and overfilling of single-use bags. Controlled plate-based freezing and thawing of single-use bags prevents loss of product quality due to cryoconcentration and reproducible freezing and thawing.

  • The Trusted One

    With more than 300.000 RoSS shells sold and 400 platform systems commissioned, Single Use Support is a trusted pioneer in biopharma for optimizing drug substance handling. 
Preview of Single Use Support's ebook about advanced atmp fluid management

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eBook: Advanced ATMP Fluid Management

The manufacturing and logistics processes for small volumes of ATMPs are complex, and there are still weaknesses, particularly in the areas of inter-site transportation, aseptic aliquotation and cryopreservation. 

In order to move ATMPs, which are typically packaged in single-use bags, from point A to point B in the most effective and efficient manner, there is an urgent need for reliable equipment that covers the steps of filling, freezing, shipping, thawing and draining. All of these process steps require robustness, ease of use, sterility and fast handling. Single Use Support helps address the various challenges of low-volume fluid and cold chain management with innovative end-to-end process solutions.

Find guidance and download the new eBook.

eBook: Advanced ATMP Fluid Management
 

Robust storage & shipping

  • RoSS technologies provide process flexibility for smallest volumes with highest accuracy:

    • Closed, robust and tamper-evident protection of your single-use bag for highly valuable drug substances
    • Vendor-agnostic and hence compatible to other systems during senstive freezing applications
    • Process flexibility for safe handling regardless of type and size of bag manufacturer without being trapped in siloed biopharma process solutions 
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  • Process diagram illustrating small-volume drug substance handling in biopharma manufacturing

Products

Downloads

Preview of Single Use Support's solution overview about handling small volumes
Solution Overview Small Volumes
Preview of Single Use Support's solution overview about handling small volumes
Solution Overview Small Volumes
 
Preview of Single Use Support's application note about controlled filling and freezing of cells
App Note: "Bestcellers": Controlled Filling & Freezing of Cells
Preview of Single Use Support's application note about controlled filling and freezing of cells
App Note: "Bestcellers": Controlled Filling & Freezing of Cells
 
Preview of a guide about viral vector manufacturing
Guide: Challenges in Viral Vector Manufacturing
Preview of a guide about viral vector manufacturing
Guide: Challenges in Viral Vector Manufacturing
 

More information

Advancements in Small Volumes Drug Freezing Techniques

Advancements in Small Volumes Drug Freezing Techniques

At the beginning of drug discovery you always deal with small volumes. Handling the cooling of drug substances in small quantities may seem straightforward, yet the intricacies involved are often more complex than anticipated. Traditionally, the u...

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Alexander Fuchs
Small volumes of ATMPs: Safe handling of single-use bags

Small volumes of ATMPs: Safe handling of single-use bags

In recent years cell and gene therapies (CGT) have proven to be promising approaches to personalized medicine. Patients needing a cell and gene therapy as an advanced therapy medicinal product (ATMP) rely on their treatment being ready as soon ...

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Michael Mühlegger
Increasing Patient Safety: Risk assessment for small volume fluid management

Increasing Patient Safety: Risk assessment for small volume fluid management

Advanced cell and gene therapies, such as autologous therapies, exhibit certain specific requirements. The scale of such therapies is very different from what we typically see in conventional biopharmaceutical manufacturing processes in commercial...

Jonathan Haider
Jonathan Haider

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