• Image of RoSS.pFTU Large-Scale for controlled freezing and thawing of larger volumes of drug substances, on a transparent background.

Plate freezer biopharma | RoSS.pFTU Large-Scale

Plate freezer biopharma | RoSS.pFTU Large-Scale

Single Use Support's large scale system is a plate-based freeze-thaw unit for any scale and batch size. The system is compatible with single-use bags and bottles of all sizes and manufacturers and enables a controlled process down to -80°C of up to 400L per batch.  

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Green icon of a thermometer on a transparent background demonstrating temperature control
Down to -80°C
Green icon of configuration settings on a transparent background demonstrating controlled rate freezing and thawing in biopharma
Controlled freeze-thaw
Green icon of a water droplet and an arrow on a transparent background demonstrating scalability
Up to 400L+/Batch

Features and benefits of RoSS.pFTU Large Scale

  • Enables controlled freezing down to -80 °C with highest possible speed and accuracy
  • Capacity of up to 400L and more, depending on bag type
  • Single-use bag independent: any bag vendor, any size
  • Hybrid option is suitable for both single-use bags and bottles
  • Best product stability results for mABs and BDS
  • Fully automated and cGMP-compliant
  • Combination with RoSS® shells for optimal protection and handling of single-use bags during freezing

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Advantages of controlled rate plate freezers

  • Graphic of two frozen single-use bags showing different freezing results

  • To demonstrate the effects of cryoconcentration, Naphthol Blue Black was used as a visual marker. The intensity of the blue coloration indicates the concentration of dissolved substances within the frozen solution.

    Slow uncontrolled freezing (A)

    In contrast, bags frozen in a static freezer show uneven solute distribution. Dark blue areas, especially in the lower regions of the bag, highlight significant cryoconcentration.


    Fast controlled freezing (B)

    Bags frozen using our plate-based controlled rate freezer show a uniform distribution of solutes. The result is a consistent, light-blue hue with a distinct white line through the center indicating minimal cryoconcentration.

Downloads

Preview of datasheet for RoSS.pFTU Large Scale freeze-thaw unit by Single Use Support
Datasheet: RoSS.pFTU Large Scale
Preview of datasheet for RoSS.pFTU Large Scale freeze-thaw unit by Single Use Support
Datasheet: RoSS.pFTU Large Scale
 
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
Whitepaper: RoSS.pFTU - Controlled scalable freezing
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
Whitepaper: RoSS.pFTU - Controlled scalable freezing
 
Preview of Single Use Support's case study about scalable freezing and thawing
Study: Scalable freezing & thawing of pharmaceutical bulk drug substance
Preview of Single Use Support's case study about scalable freezing and thawing
Study: Scalable freezing & thawing of pharmaceutical bulk drug substance
 

Scalable freeze-thaw platforms

  • Single Use Support platforms provide insular solutions for the freeze/thaw processes of each clinical phase. Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.

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  • Graphic of different scale-up stages for freeze-thaw systems used in biopharmaceutical manufacturing.

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