Freeze-Thaw platform

Plate freezing & thawing

Laboratory benchtop freezer | RoSS.pFTU Benchtop

Laboratory benchtop freezer | RoSS.pFTU Benchtop

RoSS.pFTU Benchtop is the controlled rate plate freezer for labs to perform freezing and thawing of 2D single-use bags for clinical studies, clinical trials and cell and gene therapies. Best suitable for single-use bioprocess containers of 1mL up ...

Down to -80°C

Up to 10L

Controlled freeze-thaw

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Laboratory freezer | RoSS.pFTU Lab-Scale

Laboratory freezer | RoSS.pFTU Lab-Scale

Single Use Support's plate-based laboratory freezer is the perfect solution for clinical studies conducted in labs and, above all, if you want to start a controlled, cGMP-compliant and scalable freezing & thawing process. The system is compati...

Down to -80°C

Controlled freeze-thaw

Up to 10L

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Plate freeze & thaw | RoSS.pFTU Mid-Scale

Plate freeze & thaw | RoSS.pFTU Mid-Scale

Single Use Support's mid scale freezer is a plate-based freeze-thaw system designed to protect your preferred single-use bag during cryogenic applications. The system is compatible with single-use bioprocess containers of all sizes and manufactur...

Down to -80°C

Controlled freeze-thaw

Up to 100L/batch

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Plate freezer biopharma | RoSS.pFTU Large-Scale

Plate freezer biopharma | RoSS.pFTU Large-Scale

Single Use Support's large scale system is a plate-based freeze-thaw unit for any scale and batch size. The system is compatible with single-use bags and bottles of all sizes and manufacturers and enables a controlled process down to -80°C of up t...

Down to -80°C

Controlled freeze-thaw

Up to 400L+/Batch

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Bulk drug freezer | RoSS.pFTU XL

Bulk drug freezer | RoSS.pFTU XL

The extra large scale freezing platform system is an automated plate-based freeze-thaw unit for 500 liters per batch of liquid substances including vaccines, media, buffer solutions or other drug substances. The established RoSS.pFTU platform syst...

Down to -80°C

Controlled freeze-thaw

Up to 500L+/Batch

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Blast freezing & thawing

Blast freezer for pharmaceuticals | RoSS.BLST

Blast freezer for pharmaceuticals | RoSS.BLST

RoSS.BLST is a GMP-compliant system for blast freezing & thawing of drug substances. It is suitable for any primary packaging from all manufacturers and allows freezing and thawing within a temperature range of -80°C to +40°C. The modular and ...

Capacity for up to 300L

Modular Interior

Down to -80°C

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Plate freeze & thaw for bags & bottles | RoSS.pFTU Large-Scale Hybrid

Plate freeze & thaw for bags & bottles | RoSS.pFTU Large-Scale Hybrid

RoSS.pFTU Large-Scale Hybrid freezes and thaws larger volumes of drug substances in both single-use bioprocess containers and bottles. All in one: Plate-based freezing of single-use bags, protected in RoSS shells, and air flow freezing of bottles ...

Down to -80°C

Controlled freeze-thaw

Up to 400L+/Batch

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Crogenic freezing

Cryogenic freezer | RoSS.LN2F

Cryogenic freezer | RoSS.LN2F

RoSS.LN2F is a powerful cryogenic controlled rate freezer for cryopreservation down to -170°C. An enclosed and innovative platform system for dosed freezing for cell and gene therapies eliminates direct exposure and the need for mechanical compres...

Increased cell viability

Down to -170°C

Down to < 250mL/ Bag

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Ultra-low temperature storage freezer

Ultra-low temperature storage freezer | RoSS.ULTF

Ultra-low temperature storage freezer | RoSS.ULTF

RoSS.ULTF is an upright ultra-low temperature storage freezer for frozen drug substances in different sizes. The ultra cold storage freezer keeps the desired set point temperature down to -80°C. It is compatible with RoSS Shells to protect your b...

Down to -80°C

Capacity for up to 300L

Modular Interior

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Complementary products

Single-use thawing & shaking system | RoSS.SHAK

Single-use thawing & shaking system | RoSS.SHAK

RoSS.SHAK is your reliable shaker to regain the highest quality and homogeneity of the drug substances in single-use bags placed in RoSS shells. The movement and the desired speed settings allow a smooth thawing and agitation of the drug substanc...

Product homogeneity

Up to 240L per run

Bag independent

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Mobile gripper arm | RoSS.LODR

Mobile gripper arm | RoSS.LODR

With RoSS.LODR, ergonomic work is rethought. The mobile gripper arm ensures ergonomic handling of the RoSS® shell for any loading or unloading activity, whether it be from the RoSS.FILL to the RoSS.RACK or the RoSS.RACK to RoSS.pFTU. The innovativ...

For bags up to 50L

Ergonomic handling

Increased productivity

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Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU

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Whitepaper: RoSS.pFTU - Controlled scalable freezing

As one of the most essential parameters in terms of achieving control over freezing & thawing bulk, the freezing rate has been considered and evaluated in different tests. Using the ice front growth speed as a leverage had a significant impact on controllability and, as a result, on protein quality.

Whitepaper: RoSS.pFTU - Controlled scalable freezing

Whats makes our freeze-thaw platforms so special?

Fully automated
Fully-automated freeze & thaw process, at highest possible speed and accuracy. CFR Part 11 and GMP-compliance as a further milestone for the biopharma manufacturers. Freeze/thaw recipe for lab scale also transferable for large scale.
Unrestricted Scalability
Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.
Flexibility
Compatible with single-use bags of all established manufacturers, sizes and capacities. Hybrid version of plate freezers to freeze & thaw vials, bottles and single-use bags in one platform possible. Or blast freezing technologies for controlled rate cryogenic down to -170°C.
Safety
Taking the safe and controlled freezing of high-value biopharmaceuticals to a new level: A tamper-evident closed system with optimal freezing kinetics leads to proven product viability and a freezing process with best stability results for mABs, BDS, CGT, ADCs, viral vectors or any other vaccine.

Graphic of different scale-up stages for freeze-thaw systems used in biopharmaceutical manufacturing.

Advantages of controlled rate plate freezers

To demonstrate the effects of cryoconcentration with different freezing techniques, Naphthol Blue Black was used as a visual marker. The intensity of the blue coloration indicates the concentration of dissolved substances within the frozen solution.

Slow uncontrolled freezing (A)
The bag frozen in a static freezer shows uneven solute distribution. Dark blue areas, especially in the lower regions of the bag, highlight significant cryoconcentration.

Fast controlled freezing (B)
The bag frozen using our plate-based controlled rate freezer shows a uniform distribution of solutes. The result is a consistent, light-blue hue with a distinct white line through the center indicating minimal cryoconcentration.

The close contact between freezing plates and liquid substance within the plate freezer significantly speeds up the freezing process, resulting in homogeneous freezing with controlled ice front growth from the bottom and top preventing the effects of cryoconcentration.

Downloads

Preview of datasheet for RoSS.pFTU scale overview by Single Use Support

Guide: Scale overview RoSS.pFTU

Whitepaper: RoSS.pFTU - Controlled scalable freezing

Preview of Single Use Support's case study about the ROI of bulk freezing

Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

Frequently asked questions

What is the difference between a blast freezer and a plate freezer?

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While blast freezers use cold air that is blasted on products that are yet to be frozen, plate freezers work via direct contact between the cooled plates and the products.

What is plate freezing application of refrigeration?

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The fields of application of plate freezers are manifold, since they are able to deliver a very consistent and fast freezing process. Therefore, they are, for instance, an essential tool in biopharma industry, where the quality of highly delicate products needs to be maintained when bringing them to ultra-low temperatures.

What is a pharmaceutical-grade freezer?

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A pharmaceutical-grade freezer is a freezer that is designed to freeze and store pharmaceutical substances – for instance vaccines – in a secure and efficient manner. In order to be able to cope with the high fragility of these products, there are several aspects in which they differ from ordinary kitchen freezers.

What is a medical freezer?

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Medical freezers are specifically designed to store medical substances. Since these goods come with specific needs, the according devices have to meet several criteria that set them apart from ordinary household freezers.

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Plate freezing: best approach for freezing biopharmaceuticals