Freeze & ULT Storage

Efficient bulk drug substance freezing and ultra cold storage

Partner with Single Use Support and build a harmonized freeze-to-store workflow. Increase cold chain capacity, reduce manual handling, and scale within your existing infrastructure.

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Why freezing and storage shouldn't be designed independently

While drug substance volumes are increasing, most facilities are constrained by their existing infrastructure, and cold chain capacity becomes a bottleneck. As a result, freezing and ultra-cold storage processes are often designed as separate steps. This is where most inefficiencies and risks start to appear.

Risks of cross-contamination: additional handling and transfer steps in disconnected workflows increase the risks of contamination.

Operator dependency: at scale, the lack of harmonization between freezing and storage leads to extra-handling steps and operator hours.

Compliance risks: fragmented freezing and storage systems creating compliance & data integrity gaps.

Person in a lab coat working with large white containers in a laboratory setting

High-Capacity Cold Chain for Bulk Drug Substance

Single Use Support's cold chain solutions enable efficient and scalable freeze-to-store workflows.

  • Controlled freezing: Our RoSS.BLST platform delivers controlled, high-capacity freezing of bulk drug substances. It is designed to offer a best-in-class ratio of chamber volume to overall footprint, enabling efficient use of available space.
  • Batch transfer: Frozen drug substance is transferred to storage using mobile transport racks. Integrated wheels or low-profile rollers eliminate additional handling steps and reducing the risk of errors and contamination.
  • Ultra-Cold Storage: The RoSS.ULTF platform provides scalable, ultra‑cold storage for bulk drug substances. Optimized for bulk drug substances, it enables the storage of complete frozen batches without splitting, reducing internal transport steps, and simplifying inventory management.
Person in a lab coat standing next to a large metal storage unit with shelves filled with bottles in a laboratory setting.

Efficiency gains of a harmonized freeze-to-store workflow

  • Higher capacity with the same infrastructure.
  • Compliant and data‑ready: a continuous workflow enables consistent electronic record-keeping across freezing and storage.
  • Reduced manual handling and operator dependency
  • Safer bulk drug substance handling with reduced contamination risk.

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Download App Note

App Note: Freezing and Storage of Bulk Drug Substance Batches

With rising biologics volumes, and while facilities remain unchanged, freezing and storage are increasingly treated as separate unit operations. This leads to fragmented workflows with additional handling steps, increased internal transport, and elevated risk.

This app note explores how to build freezing, transfer and ultra-cold storage steps as one continuous operation, ensuring a safe, scalable cold chain process for bulk drug substance batches.

App Note: Freezing and Storage of Bulk Drug Substance Batches
 

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