Applications by Modality
Fluid and cold chain management across biopharma therapies
From monoclonal antibodies, bioconjugates, and mRNA, to viral vectors, cell & gene therapies and other vaccines, each modality presents unique fluid handling and cold chain challenges. Single Use Support provides flexible solutions for aseptic filling, fluid management, and controlled freeze-thaw processes that help protect valuable drug substances throughout development, manufacturing, storage, and transport.
Monoclonal Antibodies (mAb)
Controlled processes play a vital role for monoclonal antibodies (mAbs) manufacturing processes. mAbs require special care and sensitive handling at every step of the development and production, as well as in logistics, so as not to compromise their effectiveness.
Antibody-Drug Conjugates (ADC)
Bioconjugates represent a rising class of biopharmaceuticals wherein at least one of the reactants is a biomolecule, often an antibody, protein, or oligonucleotide. The most famous example is the class of antibody-drug conjugates (ADCs).
Messenger RNA (mRNA)
Temperature plays a key role in the Messenger RNA (mRNA) supply chain, as single doses biotherapeutics or vaccines must be kept at temperatures similar to those used in their clinical trials: -70°C (-94°F).
Viral Vectors
With the discovery of new fields of application for viral vectors in gene therapy comes an increased need for dedicated solutions along their supply chain
Plasmid DNA (pDNA)
Plasmid DNA (pDNA) is used as a starting material for the production of mRNA, most commonly known in the context of COVID-19 vaccines. In addition, pDNA is used at the staring point of producing viral vectors, such as AAVs (Adeno-Associated Virus Vectors) and Lentiviral Vectors.
Vaccines
Single-Use Technolgies offer the best advantages to guarantee the needs in today's vaccine production. Due to the highly flexible and scalable nature of single-use components they cover the entire biopharmaceutical manufacturing process, including upstream, downstream, fill-finish and the gaps in-between.
Advanced Fluid Management for Cell and Gene Therapies
Cell Therapies
Fluid Management Solutions around Single-Use Technologies for Cell Therapies Applications | Autologous Cell Therapy | Allogeneic Cell Therapy
Gene Therapies
Fluid Management Solutions around Single-Use Technologies for Gene Therapies |Primary Packaging | Fill & Drain | Freeze & Thaw | Transport | Gene therapy solutions