Monoclonal Antibodies (mAbs)

MONOCLONAL ANTIBODIES (MABS)

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Safe Handling and Freezing/Thawing of Monoclonal Antibodies (mAbs)

Controlled processes play a vital role for monoclonal antibodies (mAbs) manufacturing processes. mAbs require special care and sensitive handling at every step of development and production, as well as in logistics, so as not to compromise their effectiveness. Additionally, controlled andfast freezing and thawing ratescan add to improved levels of quality and lead to better overall results.

Guide for mAb manufacturing - 5 Most Overlooked Challenges

Guide for monoclonal antibody manufacturing with regards to fluid and cold chain management - 5 Most Overlooked Challenges. In detail:

Efficiency in CHO cell expansion process
Scalability in fluid management
Protein aggregation during mAb freezing & thawing
Contamination risks
Efficiency in mAb production

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Guide: Challenges in biopharmaceutical fermentation

Guide about microbial or mammalian fermentation with regards to fluid and cold chain management challenges. In detail:

Advanced Bulk Plate Freezing replacing Spray Drying
Protection of Bags Reduce Product Loss
Scalability in Yeast, Bacterial or Fungal Fermentation
Speed of Large Volume Filling and Freezing
Integrated End-to-End Logistics in Continuous Production

Learn more to navigate 5 of these most overlooked challenges in this Fermentation Guide.

Guide: Challenges in biopharmaceutical fermentation

Single-Use Technologies in Monoclonal Antibodies Production

Single-use technologies are highly flexible and scalable; thus, they offer the ideal solution for processing antibodies, cells and genes in a variety of volumes.

The growing range of therapies and compounds calls for plants and systems that are or can be adapted to the increased speed of development and production as well as constantly changing requirements. In the case of monoclonal antibodies special focus should be put on viscosity: As a result of protein-protein interactions, concentrated mAb solutions can exhibit high levels of viscosity that may pose challenges during the manufacturing process.

The ROI of bulk freezing with plate freezers

The switch from cryovessels to plate-based freeze & thaw single-use technologies is, not least, a matter of costs. To determine the return on investment (ROI), different cost drivers were identified and evaluated. Discover the comparison of cryovessels, blast freezers and plate-based freezers in this case study.

Preview of Single Use Support's case study about the ROI of bulk freezing

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Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

An CDMO aspires to achieve improved freezing control, uniformity, and scalability when freezing BDS. New technologies are meant to reduce the need for manual handling as well as increase process efficiency and throughput. The goal was to evaluate and determine the return on investment (ROI) of cryovessels and plate freezers when freezing bulk.