BIOCONJUGATES

Close-up of a blue bioconjugate molecule structure on a blurred background.

Bioconjugates Manufacturing

Bioconjugates represent a rising class of biopharmaceuticals in which at least one of the reactants is a biomolecule, often an antibody, protein, or oligonucleotide. The most famous example is the class of antibody-drug conjugates (ADCs).

ADCs comprise an antibody that is joined by a chemical linker to a biologically active drug or a cytotoxic compound. The monoclonal antibodies that make up the antibody component of ADCs can be carefully designed to target specific cells, such as tumor cells.

Preview of a guide about ADC manufacturing

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Guide: Challenges in ADC Manufacturing

Guide for bioconjugate manufacturing with regards to fluid and cold chain management - 5 Most Overlooked Challenges. In detail:

  • Protection against ADC toxicity
  • Accuracy in fluid management
  • Maintaining ADC stability after freeze-thaw cycles
  • Transition from lab to commercialization
  • Cost considerations of equipment

Learn more to navigate 5 of these most overlooked challenges in this ADC Manufacturing Guide.

Guide: Challenges in ADC Manufacturing
 

Safe Handling of Antibody-Drug Conjugates (ADCs)

  • Any breakage of sample containers holding ADCs or their cytotoxic components could pose a serious threat to staff safety. Careful handling and reliable protection are required throughout the entire production and logistics process. Single Use Support’s RoSS® shell (a robust shell system for frozen storage and shipping), comprising an outer sleeve of robust stainless-steel and an adaptive inner layer of 3D foam, forms a closed system around single-use systems and can contribute to the safe transport and storage of high-value and potentially harmful substances.

  • A close-up image of a frozen RoSS Shell protecting a single-use bag.

More Information

ADC manufacturing: Process, Challenges & Solutions

ADC manufacturing: Process, Challenges & Solutions

Antibody drug conjugates (ADCs) are a promising alternative for cancer therapy. Due to the targeting quality of the monoclonal antibody (mAb) in combination with a highly toxic payload drug, it becomes easier to target cancer cells without potenti...

Michael Mühlegger
Michael Mühlegger
Controlled freezing of ADCs

Controlled freezing of ADCs

ADCs (Antibody Drug Conjugates) are an incredibly promising treatment for cancer or autoimmune diseases - but they come with challenges in manufacturing and safe handling.  Controlled freezing is an increasingly important topic in ADC production. ...

Alexander Fuchs
Alexander Fuchs
Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure ster...