FILL & FILTRATION

Image of an operator working with aseptic filling and filtration system for single-use biopharmaceutical bags.

Safe and efficient fill-filtration workflows for biopharma

In biopharmaceutical manufacturing, fill-filtration is a critical process step that prepares drug substances for freezing, storage, transport, or further processing in single-use bioprocess containers.

To ensure product quality and regulatory compliance, such as GMP EU Annex 1, bioprocess fluids must be filtered, filled, and aliquoted with a high degree of accuracy and consistency. However, manual workflows and process variability can increase the risk of product loss and contamination.

Single Use Support's solutions for filling and filtration workflows

Single Use Support helps manufacturers overcome these challenges through automated, GMP-ready fill-filtration solutions. By combining precise filling technologies with recipe-driven process control, the systems improve reproducibility, reduce product loss, and support seamless scale-up from process development to commercial manufacturing.

Platforms for Fill-Filtration processes

Primary & Secondary Packaging

Case study on automating the filling process. Preview image with a tablet and equipment on a white background.

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RoSS.FILL: Automating the filling process

It is still common practice to manually fill drug substances into primary packaging. A biopharmaceutical manufacturer in the Netherlands sought to transition from manual filling of single-use bags to an automated process. To support this decision, a comprehensive assessment comparing the costs, benefits, and limitations of manual versus automated bulk drug substance filling was required.

The findings offer insights into the return on investment (ROI) and additional advantages that extend well beyond cost savings.

RoSS.FILL: Automating the filling process
 

More Information

Bubble point test: Purpose & Procedure

Bubble point test: Purpose & Procedure

Ensuring the integrity of filtration processes is fundamental for the safety of bioprocessing. Among the array of methods available for assessing filter integrity, the bubble point test emerges as one of the most frequently used techniques. By scr...

Jonathan Haider
Jonathan Haider
Evolving Aseptic Filling in Biomanufacturing

Evolving Aseptic Filling in Biomanufacturing

In the dynamic landscape of pharmaceutical manufacturing, the journey from laminar flow to automated fluid management has been nothing short of transformative. This evolution, marked by innovation and adaptability, has reshaped the way smaller vol...

Michael Eder
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Fluid management in biopharma: Advantages of single-use systems

Fluid management in biopharma: Advantages of single-use systems

Fluid management in biopharma has changed considerably in recent years. With the advances in life science and the related healthcare adaptations, the manufacturing and supply chain divisions of biopharmaceutical companies are going through a major...

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Khalil Essani

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