Fill & Filtration

Image of an operator working with aseptic filling and filtration system for single-use biopharmaceutical bags.

Reliable fluid management for fill-filtration in biopharma

In biopharmaceutical manufacturing, fill-filtration is a critical process step that prepares drug substances for freezing, storage, transport, or further processing in single-use bioprocess containers.

To ensure product quality and regulatory compliance, bioprocess fluids must be filtered, filled, and aliquoted with a high degree of accuracy and consistency. However, manual workflows and process variability can increase the risk of product loss, contamination, and process inconsistency.

Single Use Support's solutions for fill-filtration workflows

Single Use Support helps manufacturers overcome these challenges through automated, GMP-ready fill-filtration solutions. By combining precise filling technologies with recipe-driven process control, the systems improve reproducibility, reduce product loss, and support seamless scale-up from process development to commercial manufacturing.

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RoSS.FILL: Automating the filling process

It is still common practice to manually fill drug substances into primary packaging. A biopharmaceutical manufacturer in the Netherlands sought to transition from manual filling of single-use bags to an automated process. To support this decision, a comprehensive assessment comparing the costs, benefits, and limitations of manual versus automated bulk drug substance filling was required.

The findings offer insights into the return on investment (ROI) and additional advantages that extend well beyond cost savings.

RoSS.FILL: Automating the filling process
 

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