Freeze & Thaw

Close-up image of an operator placing RoSS.KSETs into a RoSS.pFTU Lab-Scale solution to freeze small volumes of drug substances.

Reliable cold chain management for biopharma manufacturing

Freezing and thawing of drug substances are critical process step in biomanufacturing, enabling the safe storage, transport, and management of valuable drug substances throughout the cold chain.

Maintaining product integrity during freezing and thawing can be challenging, as inconsistent temperature profiles, inadequate container protection, and uncontrolled handling can adversely affect product quality and operational efficiency.

Single Use Support's solutions for freeze-thaw workflows

Single Use Support provides advanced freeze-thaw solutions designed to ensure controlled, reproducible, and scalable cold chain operations. By combining protected single-use bioprocess containers with automated freezing and thawing technologies, the controlled freezers help preserve critical quality attributes (CQA), minimize product loss, and support efficient manufacturing from clinical development through commercial-scale production.

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Operator handling biologics with gloves on a cold chain integrity system, featuring text about biologics protection.

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Cold Chain Integrity for Biologics

What impact does controlled end-to-end cold chain management have on preserving the quality, potency and safety of biologics? Find out how Single Use Support's modular, automated technologies for single-use bags and bottles minimize cryoconcentration, prevent container damage and ensure consistent, sustainable handling that aligns with Annex 1 throughout bioprocessing.

Cold Chain Integrity for Biologics
 

More Information

Blast freezer in biopharma: What, when and why?

Blast freezer in biopharma: What, when and why?

Blast freezers have emerged as a reliable solution in the biopharmaceutical industry. However, pharmaceutical bulk freezing is not just about turning liquids into solids; it is also about preserving the integrity and quality of life-saving drug s...

Michael Eder
Michael Eder
Freezing bottles – 5 critical considerations

Freezing bottles – 5 critical considerations

Freezing drug substances to ultra-cold temperatures is a standard step in biopharmaceutical manufacturing. Yet, beyond simply cooling, it’s the critical quality attributes (CQA), like product safety, consistency, and process efficiency, that trul...

Claus Exenberger
Claus Exenberger
Plate freezing: best approach for freezing biopharmaceuticals in single-use bags

Plate freezing: best approach for freezing biopharmaceuticals in single-use bags

Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation in flat primary packaging, such as single-use bags. Things ...

Alexander Fuchs
Alexander Fuchs