ANTIBODY-DRUG CONJUGATES (ADCs)

Precision fluid management for ADCs

Antibody-drug conjugates are advancing in potency, value, and complexity, driving improvements in cancer treatment. At the same time, safety expectations and the need for GMP-compliant, efficient manufacturing continue to rise.

Single Use Support partners with CDMOs to provide reliable fluid and cold chain management for critical ADC handling. Automated and controlled systems support accuracy, process control, and safety across manufacturing workflows.

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Challenges of ADC manufacturing

  • Cytotoxicity and operator safety: Manual handling of highly potent cytotoxic payloads exposes operators to significant risk and increases the likelihood of process deviations, human error, and safety-related incidents.

  • Annex 1 compliance: HPAPI and ADC manufacturing environments require robust contamination control strategies that support Annex 1-aligned closed ADC handling concepts.

  • Accuracy: Product loss can occur as a result of inaccurate or inefficient aliquoting into bioprocess containers, system excessive holdup volumes, or bag and bottle integrity failures, directly impacting yield and cost of goods.
Image of Single Use Support's fluid management system for small volume filling and filtration in biopharma.

Why choose Single Use Support?

With a broad portfolio of safe filling and controlled cold chain solutions for single-use bags and bottles, Single Use Support enables a smooth, reliable and GMP-ready ADC workflow from bench through commercial production.

  • Safety by design: Closed single-use flow paths reduce operator exposure and minimize product loss in cytotoxic environments.
  • Automated accuracy: Filling at high dosing precision with reproducible process control and electronic records.
  • Fit to your workflow: Configurable, modular systems and single-use assemblies can be integrated seamlessly into existing ADC processes.
  • Scalability: Move from bench to commercial scale without re-engineering.

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Preview of a guide about ADC manufacturing

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Guide: Navigating 5 overlooked ADC manufacturing challenges

Fluid and cold chain management entail multiple challenges in antibody-drug conjugate manufacturing, including the following five often overlooked aspects:

  • Handling ADC cytotoxicity
  • Precision in fluid management
  • Maintaining ADC stability after freeze-thaw cycles
  • Transition from bench scale to commercial production
  • Cost considerations of filling & freezing equipment

Learn more about how to navigate these 5 underestimated challenges in this ADC Manufacturing Guide.

Guide: Navigating 5 overlooked ADC manufacturing challenges
 

More Information

Are these 7 ADC handling considerations on your radar?

Are these 7 ADC handling considerations on your radar?

Every new generation of ADC is more potent, more complex, and more valuable than the last. At the same time, manufacturing timelines are tightening, and safety expectations are rising. In this environment, traditional approaches to fluid handling ...

Alexander Fuchs
Alexander Fuchs
Fluid management in HPAPI manufacturing: Getting from high risk to controlled efficiency

Fluid management in HPAPI manufacturing: Getting from high risk to controlled efficiency

In high potent active pharmaceutical ingredients (HPAPI) and antibody-drug conjugate (ADC) manufacturing, the most critical risks are often not visible at first glance. While much attention is given to payload potency and containment concepts, it...

Jonathan Haider
Jonathan Haider
ADC cytotoxicity: How to provide operator safety

ADC cytotoxicity: How to provide operator safety

Antibody‑drug conjugates (ADCs) have become a key treatment option in oncology, merging the targeted specificity of antibodies with highly potent cytotoxic payloads. While their therapeutic potential is remarkable, this same potency poses substant...

Michael Eder
Michael Eder

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