• Image of RoSS.pFTU Large-Scale for controlled freezing and thawing of larger volumes of drug substances, on a transparent background.

Scalable Plate Freeze-Thaw Platform | RoSS.pFTU

Scalable Plate Freeze-Thaw Platform | RoSS.pFTU

The Hybrid Freeze & Thaw platform RoSS.pFTU freezes and thaws drug substances in both single-use bioprocess containers and bottles. All in one: plate-based freezing of single-use bags, protected in RoSS shells, and air flow freezing of bottles control cold chain management of valuable liquids in both primary packagings from all manufacturers.

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Green icon of a water droplet and an arrow on a transparent background demonstrating scalability
Up to 400L+/Batch
Green icon of a thermometer on a transparent background demonstrating temperature control
Down to -80°C
Available to Lease

Scale from lab to commercial production

  • Single Use Support platforms provide insular solutions for the freeze/thaw processes of each clinical phase. Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.

  • Graphic of different scale-up stages for freeze-thaw systems used in biopharmaceutical manufacturing.

Overview of RoSS.pFTU platforms

An operator in front of controlled rate freezer RoSS.pFTU Mid-Scale by Single Use Support after cell freezing with dmso.

Features and benefits of RoSS.pFTU

  • Enables controlled freezing down to -80 °C with highest possible speed and accuracy
  • Capacity of up to 400L, depending on bag type
  • Single-use bag independent: any bag vendor, any size
  • Best product stability results for mABs and BDS
  • Fully automated and ready for cGMP use
  • Combination with RoSS® shells for optimal protection and handling of single-use bags during freezing
  • Standard configurations are available with short lead times to support accelerated project timelines.

Our customers trust in us:

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Advantages of controlled rate plate freezers

  • Graphic of two frozen single-use bags showing different freezing results

  • To demonstrate the effects of cryoconcentration, Naphthol Blue Black was used as a visual marker. The intensity of the blue coloration indicates the concentration of dissolved substances within the frozen solution.

    Slow uncontrolled freezing (A)

    In contrast, bags frozen in a static freezer show uneven solute distribution. Dark blue areas, especially in the lower regions of the bag, highlight significant cryoconcentration.


    Fast controlled freezing (B)

    Bags frozen using our plate-based controlled rate freezer show a uniform distribution of solutes. The result is a consistent, light-blue hue with a distinct white line through the center indicating minimal cryoconcentration.

Downloads

Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
Whitepaper: RoSS.pFTU - Controlled scalable freezing
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
Whitepaper: RoSS.pFTU - Controlled scalable freezing
 
Preview of Single Use Support's study about scalable freezing
Study: Scalable freezing of protein-based biologics
Preview of Single Use Support's study about scalable freezing
Study: Scalable freezing of protein-based biologics
 

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