RoSS.FILL Bottle - Bottle Filling System for Biopharma

Aseptic filling and filtration system for single-use bottles

The fully automated RoSS.FILL aseptic single use bottle filling and filtration system enables worry-free filling and filtration of your liquid drug and non-drug substances into bottles. 

With its high filling accuracy, the platform provides continuous filling for up to 20 bottles at the same time as a closed single use filling system.


Fast lead times

Worldwide shipping

Personal customer service

Our customers trust in us:

Rentschler Biopharma SE



Features and Benefits of our single use bottle filling machine

The cGMP compliant design of the RoSS.FILL bottle filling and filtration machine allows controlled and automated transfer of your fluids without limitations for your custom process:

  • Parallel or sequential filling possible: Up to 20 bottles (up to 5L) per rack get connected to control unit at point of use
  • Hygienic Design: Easy to clean surface thanks to improved design 
  • Single-Use Filtration Assembly gets easily placed on the system 
  • TPE Automatic Sealer & Stepper Pinch Valves for filling and venting line
  • GMP, CFR Part 11 compliant software control unit can be used with the bottle rack or the bag/shell rack
  •  Hiqhest Accuracy with precise scales
  • Hybrid solution for single-use bag filling (see RoSS.FILL) and bottles (with Flex Rack) 
  • Same control unit (just switching rack) 
  • Optional MES integration to DeltaV or other
Single use bottle filling RoSS.FILL bottle
RoSS.FILL Bottle_V1_Single Use Support

Advanced Sealer & Stepper Pinch Valve

2 functions in 1 device: Variable fluid control for fast filling + simple aseptic decoupling

Automated Sealing Function:

  • Dropless disconnection by sealing
  • No need for cumbersome post processing of metal seals and giving the benefit of removing sharp edges
  • Fully aseptically closed – no risk of leakage
  • Simple Aseptic Decoupling: safer, automated disconnection
  • The fully tested sealed tubings withstand a temperature of up to -190°C

Automated Stepper Function:

  • Closed or open or anywhere in between
  • Run your pump at 100% speed - allow the stepper to control the fill rate
  • Unprecedented levels of control in your fill recipe
  • Fastest filling rate
  • Fill several bottles in parallel
Sealer Valve_3

Data sheets

Datasheet RoSS.FILL Bottle

Datasheet RoSS.FILL Bottle

Filesize: 0.62 MB – Mime-Type: application/pdf

RoSS.FILL Scale Overview

Scale Overview RoSS.FILL

Filesize: 1.05 MB – Mime-Type: application/pdf

Datasheet_IRIS_Single-Use Assemblies_Single Use Support

Datasheet Single-Use Assemblies

Filesize: 0.53 MB – Mime-Type: application/pdf

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RoSS.LIQU is a smart rigid tote to protect 3D single-use bags with large volumes of up to 1000L for shipping applications. This robust stainless steel transport container is re-usable and offers a sustainable solution for single-use bag shipments compared to plastic alternatives.

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Critical considerations of aseptic single use bag filling

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Enabling end-to-end process solutions for bottles

Enabling end-to-end process solutions for bottles

The Single Use Support end-to-end process for bottles can be applied independently from bottle manufacturer, it is modular and can be topped off with services such as qualifications, after-sales service and biopharma know-how.

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