Cell Banking

Cold Chain Solutions in Cell Banking

In the process of creating new drug compounds cells play an important role. However, handling of cells requires very careful and fast processes in order to guarantee best-possible quality.

When cryopreserving cells it is crucial to achieve a high cell recovery rate and ultimately optimal cell viability after thawing. Controlled cGMP-compliant and scalable freezing enables reprodicible processes and thus standardization. Study results confirm a consistent and uniform high ratio of live cell recovery after cryopreservation of cells in single-use bioprocess containers thanks to plate-based RoSS.pFTU Lab Scale leading to accelerated cell-based process workflow.

cryopreservation-process

Solutions for Optimized Cryopreservation of Cells

State-of-the-art single-use technologies improve fluid management and cold chain management of cell significantly. Elaborated solutions accelerate the process of aliquoting and freezing cells to less than 1 hour whilst providing full control over accuracy during automated aseptic dispensing and controlled freezing with liquid nitrogen down to -180°C (-292°F).

Cell Banking_Simple Aliquoting & Freezing
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Primary Packaging

RoSS.PADL

Feed Source for Aliquotation

Single-use aseptic bag filling machine RoSS.FILL

Automated Aliquotation

Single-use bag protections system with RoSS shell

Robust Protection

RoSS.LN2F_open

Controlled Rate Freezing

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Ultra-Cold Storage

Shipping drug substances in single-use bag containers safely with RoSS.SHIP

Transportation

Lab freezer for pharma with RoSS.pFTU lab scale

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Primary Packaging

IRIS Single-Use Bag (2D or 3D)

Store and ship anything from cell culture samples to large drug substance volumes reliably and on time. 2D or 3D single-use bioprocess containers in any size.

Single-use bioprocess container by Single Use Support

Feed Source for Aliquotation

RoSS.PADL | HOMOGENIZING SOLUTION

RoSS.PADL is a platform to standardize cooling of your single-use bag whilst gently massaging it to ensure a homogeneous mixture of your substance.

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Automated Aliquotation

RoSS.FILL CGT

RoSS.FILL is compatible to all single use bags and bottles and can be scaled up by attaching multiple racks. Fully automated filling system for multiple small single use bags at highest accuracy. Applicable for both, cell & gene therapies and Upstream Seed Train Intensification.

RoSS.FILL CGT
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RoSS.FILL Lab Scale

Accuracy is key: Fully automated platform system for aseptic filling of up to 12 single-use bags in standard configuration and is extendable to higher bag quantities. Most suitable for filling small volumes in cell & gene therapies or seed train intensification.

RoSS Fill-Lab Scale_Fill & Filtraton Platform
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RoSS FILL Bag

With RoSS.FILL Bag, the RoSS shell systems contained in the rack are filled with a speed of up to 200L per hour in a fully automated manner. RoSS.FILL is compatible to all single use bags and bottles and can be scaled up by attaching multiple racks.

RoSS.FILL Bag - single use bag filling and draining system machine

Robust Protection

RoSS.KSET

Single use bags with a volume of less than 250ml are covered with a first layer of soft 3D foam which is complemented by an innovative and intuitive locking mechanism. Its robust stainless steel frame protects the single use bag during freezing and shipping.

Industry 4.0 biomanufacturing RoSS.KSET for CGT bag protection
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RoSS® Shell

With the RoSS Shell system, the sensitive single use bag is covered in 3D foam, which is held by a highly robust plastic frame. Bottom and top are made of stainless steel – ideal for the freezeing process and absolutely robust.

Bulk.Stream RoSS shell

Controlled Rate Freezing

RoSS.LN2F | Liquid Nitrogen Freezer

RoSS.LN2F is a powerful cryogenic controlled rate freezer for temperatures down to -180°C/-292°F. An enclosed and innovative platform system for dosed freezing for cell and gene therapies enables no direct exposure, and no mechanical compressors are needed. This ensures a safe, low-maintenance and energy-saving handling.

Cryogenic Freezer RoSS LN2F
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Lab Scale Controlled Plate-Freezer (-80°C)

Controlled freezeing and thawing of small batches - more important than ever for cell & gene therapies and clinical studies! The plate-based freeze & thaw platform for labs RoSS.pFTU Lab Scale is the perfect solution for one or multiple single use bags of up to in total 10L. GMP-compliant computerized system optional.

Laboratory freezer RoSS.PFTU Lab Scale
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Large Scale Controlled Plate-Freezer (-80°C)

The freeze & thaw system RoSS.pFTU is a fully automated and scalable plate-based freezing unit. Both economically and in terms of product stability we have reached the next level. The plate-based platform RoSS.pFTU Large Scale is completely adapted to RoSS shell system for a batch sizes of up to 400L and more.

Pharmaceutical freezer RoSS.pFTU large scale freeze thaw platform

Ultra-Cold Storage

RoSS.FRDG | Ultra-Cold Storage

Ultra-Cold Storage for frozen drug substances in different sizes. RoSS.FRDG keeps the desired set point temperature down to -80°C.

Ultra-cold storage RoSS.FRDG

Transportation

RoSS.SHIP | Smart Cold Chain Shipping Container

RoSS.SHIP secures the cold chain storage and shipping of bulk drug substance for almost one week. With its Smart Tracking & Tracing Add-on you never loose control of your product.

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RoSS.pFTU Lab Scale

The plate-based platform for controlled freezing and thawing small batches, RoSS.pFTU Lab Scale, is the perfect solution for cell culture intensification in intermediates of one or multiple single use bags of up to in total 5L. GMP-compliant computerized system optional.

Laboratory freezer RoSS.PFTU Lab Scale
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RoSS.pFTU Mid Scale

RoSS.pFTU Mid Scale is a plate-based freeze-thaw unit for studies and small scale batches. Thawing different individual volumes of drug substance up to 70 L with ease. Based on plates, the freezing and thawing time is controlled and rapid.

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More Information

RoSS.pFTU Lab Scale - in process (1 von 9)-min

App Note: Cell Monolayer Cryopreservation

Advanced cell-based assay workflow with CryoLogyx Thaw and Test pre-plated cell and controlled, scalable freezing process solution RoSS.pFTU to achieve effective cryopreservation of cells.