BIOCONJUGATES

Close-up of a blue bioconjugate molecule structure on a blurred background.

Bioconjugates Manufacturing

Bioconjugates represent a rising class of biopharmaceuticals in which at least one of the reactants is a biomolecule, often an antibody, protein, or oligonucleotide. The most famous example is the class of antibody-drug conjugates (ADCs).

ADCs comprise an antibody that is joined by a chemical linker to a biologically active drug or a cytotoxic compound. The monoclonal antibodies that make up the antibody component of ADCs can be carefully designed to target specific cells, such as tumor cells.

Preview of a guide about ADC manufacturing

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Guide: Challenges in ADC Manufacturing

Guide for bioconjugate manufacturing with regards to fluid and cold chain management - 5 Most Overlooked Challenges. In detail:

  • Protection against ADC toxicity
  • Accuracy in fluid management
  • Maintaining ADC stability after freeze-thaw cycles
  • Transition from lab to commercialization
  • Cost considerations of equipment

Learn more to navigate 5 of these most overlooked challenges in this ADC Manufacturing Guide.

Guide: Challenges in ADC Manufacturing
 
  • Any breakage of sample containers holding ADCs or their cytotoxic components could pose a serious threat to staff safety. Careful handling and reliable protection are required throughout the entire production and logistics process. Single Use Support’s RoSS® shell (a robust shell system for frozen storage and shipping), comprising an outer sleeve of robust stainless-steel and an adaptive inner layer of 3D foam, forms a closed system around single-use systems and can contribute to the safe transport and storage of high-value and potentially harmful substances.

  • A close-up image of a frozen RoSS Shell protecting a single-use bag.

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