Image of a controlled plate freezer loaded with RoSS shells.

FREEZE-THAW PLATFORM

The Single Use Support freeze-thaw platforms provide reliable end-to-end solutions, such as plate freezers for the controlled freeze/thaw processes of any drug substance - either for clinical phases or commercialized bulk production. 

Our new freeze-thaw units are fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production.

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Plate freezing & thawing

Blast freezing & thawing

Cryogenic freezing

Ultra-low temperature storage freezer

Complementary products

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Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU

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RoSS.pFTU - Controlled scalable freezing - Whitepaper

As one of the most essential parameters in terms of achieving control over freezing & thawing bulk, the freezing rate has been considered and evaluated in different tests. Using the ice front growth speed as a leverage had a significant impact on controllability and, as a result, on protein quality.

RoSS.pFTU - Controlled scalable freezing - Whitepaper
 

Whats makes our freeze-thaw platforms so special?

  • Fully automated

    Fully-automated freeze & thaw process, at highest possible speed and accuracy. CFR Part 11 and ready for GMP use as a further milestone for the biopharma manufacturers. Freeze/thaw recipe for lab scale also transferable for large scale.

  • Unrestricted Scalability

    Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.

  • Flexibility

    Compatible with single-use bags and bottles of all established manufacturers, sizes and capacities. Plate freezers for controlled freezing and thawing of bags, blast freezers for bags and bottles, and cryogenic technology for bags and vials down to -170 °C.

  • Safety

    Taking the safe and controlled freezing of high-value biopharmaceuticals to a new level: A tamper-evident closed system with optimal freezing kinetics leads to proven product viability and a freezing process with best stability results for mABs, BDS, CGT, ADCs, viral vectors or any other vaccine.

Advantages of controlled rate plate freezers

  • To demonstrate the effects of cryoconcentration with different freezing techniques, Naphthol Blue Black was used as a visual marker. The intensity of the blue coloration indicates the concentration of dissolved substances within the frozen solution.

    Slow uncontrolled freezing (A)

    The bag frozen in a static freezer shows uneven solute distribution. Dark blue areas, especially in the lower regions of the bag, highlight significant cryoconcentration.

    Fast controlled freezing (B)

    The bag frozen using our plate-based controlled rate freezer shows a uniform distribution of solutes. The result is a consistent, light-blue hue with a distinct white line through the center indicating minimal cryoconcentration.

    The close contact between freezing plates and liquid substance within the plate freezer significantly speeds up the freezing process, resulting in homogeneous freezing with controlled ice front growth from the bottom and top preventing the effects of cryoconcentration.

  • Graphic of two frozen single-use bags showing different freezing results

Downloads

Preview of datasheet for RoSS.pFTU scale overview by Single Use Support
Scale overview RoSS.pFTU - Guide
Preview of datasheet for RoSS.pFTU scale overview by Single Use Support
Scale overview RoSS.pFTU - Guide
 
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
RoSS.pFTU - Controlled scalable freezing - Whitepaper
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
RoSS.pFTU - Controlled scalable freezing - Whitepaper
 
Preview of Single Use Support's case study about the ROI of bulk freezing
The ROI of Bulk Freezing with Plate Freezers - Case Study
Preview of Single Use Support's case study about the ROI of bulk freezing
The ROI of Bulk Freezing with Plate Freezers - Case Study
 

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Frequently asked questions

What is the difference between a blast freezer and a plate freezer?

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While blast freezers use cold air that is blasted on products that are yet to be frozen, plate freezers work via direct contact between the cooled plates and the products.

What is plate freezing application of refrigeration?

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The fields of application of plate freezers are manifold, since they are able to deliver a very consistent and fast freezing process. Therefore, they are, for instance, an essential tool in biopharma industry, where the quality of highly delicate products needs to be maintained when bringing them to ultra-low temperatures.

What is a pharmaceutical-grade freezer?

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A pharmaceutical-grade freezer is a freezer that is designed to freeze and store pharmaceutical substances – for instance vaccines – in a secure and efficient manner. In order to be able to cope with the high fragility of these products, there are several aspects in which they differ from ordinary kitchen freezers.

What is a medical freezer?

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Medical freezers are specifically designed to store medical substances. Since these goods come with specific needs, the according devices have to meet several criteria that set them apart from ordinary household freezers.

More information

Plate freezing: best approach for freezing biopharmaceuticals in single-use bags

Plate freezing: best approach for freezing biopharmaceuticals in single-use bags

Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation in flat primary packaging, such as single-use bags. Things ...

Alexander Fuchs
Alexander Fuchs
Blast freezer in biopharma: What, when and why?

Blast freezer in biopharma: What, when and why?

Blast freezers have emerged as a reliable solution in the biopharmaceutical industry. However, pharmaceutical bulk freezing is not just about turning liquids into solids; it is also about preserving the integrity and quality of life-saving drug s...

Michael Eder
Michael Eder
Sustainable freezing in biopharma: Emerging trends & the role of natural gas

Sustainable freezing in biopharma: Emerging trends & the role of natural gas

There will continue to be an ongoing need for cryopreservation and cold chain management of drug substances. However, these processes will no longer depend on F-Gases.  The utilization of F-gases, also known as fluorinated greenhouse gases, is ste...

Alexander Fuchs
Alexander Fuchs

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