Plate freeze & thaw for bags & bottles | RoSS.pFTU Large-Scale Hybrid

RoSS.pFTU Large-Scale Hybrid freezes and thaws larger volumes of drug substances in both single-use bioprocess containers and bottles. All in one: Plate-based freezing of single-use bags, protected in RoSS shells, and air flow freezing of bottles control cold chain management of valuable liquids in both primary packagings.

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Down to -80°C

Controlled freeze-thaw

Up to 400L+/Batch

Front view of RoSS.pFTU Large-Scale Hybrid for controlled freezing of bioprocess containers and biopharma bottles, on a white background.

Features and benefits of RoSS.pFTU Hybrid

Enables controlled freezing down to -80 °C with highest possible speed and accuracy
Plate-based freezing and thawing for single-use bags, protected in RoSS shells
Freezing and thawing with air flow for bottles, protected in Bottle CCUs
Capacity single-use bags: Up to 400L and more, depending on bag type
Capacity bottles: Up to 160L and more, depending on bottle type
Primary packaging independent: any vendor, any size
Best product stability results for mABs and BDS
Fully automated and cGMP-compliant
Combination with RoSS® shells or Bottle RoSS for optimal protection and handling of single-use bags and bottles during freezing

Controlling freezing and thawing of bottles

The combination of the hybrid RoSS.pFTU Large Scale and the use of CCUs (cryo control units) for bottles enables homogeneity during freezing. CCUs areattached to single-use bagsand bottles for cryogenic applications with airflow in air turbulence or blast freezers to control homogeneity and pressure at the last point of freeze.

Comparison of conventional freezer without CCU and advanced hybrid freezer with CCU showing the difference of cyocencentration.

Cryo control unit for bottles
- Insulation material made of styro foam
- Vendor agnostic and applicable to all available types and sizes of bottles
- Covers the bottle cap during freezing applications with air turbulence (blast freezing)
- Avoids volcano cryoconcentration effect or bulging enabling homogeneous freezing results

Downloads

Preview of datasheet for RoSS.pFTU hybrid freeze-thaw unit by Single Use Support

Datasheet: RoSS.pFTU Hybrid

Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU

Whitepaper: RoSS.pFTU - Controlled scalable freezing

Preview of Single Use Support's case study about scalable freezing and thawing

Study: Scalable freezing & thawing of pharmaceutical bulk drug substance

Scalable freeze-thaw platforms

Single Use Support platforms provide insular solutions for the freeze/thaw processes of each clinical phase. Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.
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Plate freeze & thaw for bags & bottles | RoSS.pFTU Large-Scale Hybrid