Knowledge

February 16, 2024

Study: Optimizing Cell Viability During CHO Cell Freezing

Alexander Fuchs | Single Use Support
Alexander Fuchs

In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability. 

February 12, 2024

Who manufactures monoclonal antibodies? Overview of mAb companies

micheal-eder
Michael Eder

In this article we take a closer look at the top five companies in terms of annual revenue in the U.S., that dominate the field of antibody research, development and production. Further, we dive in the field of promising pioneers with a focus on mAb production for the use of cancer treatments. 

February 8, 2024

Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation

Khalil Essani - Single Use Support
Khalil Essani

The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).

February 7, 2024

Regulations for Cryoprotectants in ATMP Cryopreservation

Khalil Essani - Single Use Support
Khalil Essani

Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.

February 7, 2024

Solutions for mAb development and manufacturing

BRMO
Brian Moloney

Monoclonal antibody development and manufacturing are highly specialized processes, demanding equally specialized equipment. We will discuss some essential tools and systems in this article.

February 7, 2024

Safe handling of monoclonal antibodies: Best practices

Claus Exenberger - Single Use Support
Claus Exenberger

Monoclonal antibodies bring along some special requirements in terms of safe handling. In this article, we will discover what these requirements are, and how they can be met.

February 6, 2024

Steps in Monoclonal Antibody Production

Khalil Essani - Single Use Support
Khalil Essani

From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production. 

February 6, 2024

The 3 Most Overlooked Costs in Monoclonal Antibody Production

daniel-tischler
Daniel Tischler

In the quest for efficient monoclonal antibody manufacturing, it's imperative to shed light on costs that are frequently underestimated. These costs can stem from various sources, including process development, high prices associated with biotherapeutics, and the evolving landscape of production technologies.

February 6, 2024

Challenges in monoclonal antibody production

Alexander Fuchs | Single Use Support
Alexander Fuchs

mAb production requires high levels of expertise and precision, as well as specialized equipment. Nonetheless, there are several challenges that manufacturers have to deal with.

February 5, 2024

Antibody storage: preserving monoclonal antibodies

Alexander Fuchs | Single Use Support
Alexander Fuchs

In many cases, antibodies need to be stored for varying time spans before further processing or administration. Hence, it is essential to mind the characteristic storage requirements of these valuable biologics.

February 5, 2024

Solutions for automated aseptic filling of monoclonal antibodies

BRMO
Brian Moloney

Filling monoclonal antibodies requires dedicated solutions that allow smooth and safe mAb processing. In this article, we will discuss some of the integral components in this procedure.

January 18, 2024

What are monoclonal antibodies?

micheal-eder
Michael Eder

Monoclonal antibodies are frequently used in research, diagnostics, and therapeutics. But what makes them so special? In this article, we are going to find out!