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Bioprocessing

Upstream intensification from lab to mAb manufacturing

Upstream intensification processes use high density cell banking to optimize monoclonal antibody production. How does HDCB advance cell expansion? And is seed train intensification relevant to biosimilars?

BRMO

Brian Moloney

February 12, 2025

Vaccines

7 trends in global vaccine development 2025

Vaccine production is characterized by ongoing changes, adaptations and improvements. In this article, we will take a look at 7 trends in global vaccine development.

daniel-tischler

Daniel Tischler

December 19, 2024

Bioprocessing

Seed train intensification - the next big step in biopharma?

Seed train intensification is an upstream bioprocessing strategy to improve productivty through modern technologies applying High Cell Density Cryopreservation (HCDC). Learn how seed train intensification can help manufacturers advance production of proteins, such as antibody drug products.

Khalil Essani - Single Use Support

Khalil Essani

November 28, 2024

Drug Delivery

Lentiviral vector manufacturing: Outdated or advanced gene therapy viruses?

Lentiviral vectors have become important tools in gene therapy, offering new opportunities for treating a wide array of diseases. Learn more about comparison with AAVs and how lentiviral vector manufacturing challenges – from plasmid design to aseptic filling and controlled freezing – can be solved to enhance overall manufacturing efficiency. 

BRMO

Brian Moloney

November 5, 2024

Fill & Filtration

Dual Sourcing: Strengthening the Pharmaceutical Supply Chain for Single-Use Assemblies

Dual sourcing strategies select suppliers that can meet quality standards, desired delivery times, and overall price expectations. Vendor-agnostic integrators, like Single Use Support, help provide customized single-use systems tailored to specific client needs. This allows them to select the best components and materials from multiple sources, ensuring compatibility and functionality.

1640281789974

David Seifert

October 28, 2024

Nucleic Acids

Oligonucleotide manufacturing – challenges & solutions

Oligonucleotide manufacturing. Optimizing fluid management, freezing & cold storage | Purification Oligonucleotides

michael-muehlegger

Michael Mühlegger

October 25, 2024

Nucleic Acids

Oligonucleotides simply explained

What are oligonucleotides? Nucleic acid types | RNA oligonucleotides | DNA oligos | Types of Oligonucleotides

michael-muehlegger

Michael Mühlegger

October 25, 2024

Cell & Gene Therapy

DMSO: Freezing Cells

Freezing cells is a process that requires more than simply placing them in a freezer with dimethyl sulfoxide (DMSO). It is a precise and meticulous process, where precision and expertise are essential. The goal is to achieve high cell viability and therefore high yield for cell-based therapies or cell banking.

Khalil Essani - Single Use Support

Khalil Essani

October 11, 2024

Sustainability

Sustainable Practices: The Green in Single Use Support

As company with “recognition of good performance” Single Use Support has already set ambitious goals for the upcoming years which include to obtain the ISO 14001 certification by 2025 and to reduce emissions by 30% by 2028.

Armin Lassl - Single Use Support

Armin Lassl

September 23, 2024

Freeze & Thaw

Interview with NIBRT: Innovating Freezing & Thawing in Bioprocessing

The collaboration between Single Use Support and the National Institute for Bioprocessing Research and Training (NIBRT) exemplifies a shared commitment to advancing scientific knowledge and driving innovation in the bioprocessing industry. 

micheal-eder

Michael Eder

August 13, 2024

Nucleic Acids

RNase Contamination – Challenges & Solutions

This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment

1640281789974

David Seifert

August 13, 2024

Nucleic Acids

RNase: Ribonuclease Simply Explained

RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC

1640281789974

David Seifert

August 12, 2024

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

Whitepaper: Automated Aseptic Filling

Read our Whitepaper about Automated Aseptic Filling in Pharmaceutical Manufacturing | Discover why automatic filling solutions are preferable to manual filling.