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Single-use Technology

Single-use bag manufacturers: the major players

The advanced platforms of the newest generation of single use bags are generally compatible with a variety of bag brands and volumes. One of these platforms is Single Use Support’s RoSS®, which offers the benefit of not only being bag agnostic but also highly flexible thanks to its modular design. Learn more about the biggest player in the industry!

micheal-eder

Michael Eder

March 5, 2024

Cell & Gene Therapy

Study: Optimizing Cell Viability During CHO Cell Freezing

In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability. 

Alexander Fuchs | Single Use Support

Alexander Fuchs

February 16, 2024

Monoclonal Antibodies

Who manufactures monoclonal antibodies? Overview of mAb companies

In this article we take a closer look at the top five companies in terms of annual revenue in the U.S., that dominate the field of antibody research, development and production. Further, we dive in the field of promising pioneers with a focus on mAb production for the use of cancer treatments. 

micheal-eder

Michael Eder

February 12, 2024

Cell & Gene Therapy

Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation

The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).

Khalil Essani - Single Use Support

Khalil Essani

February 8, 2024

Cell & Gene Therapy

Regulations for Cryoprotectants in ATMP Cryopreservation

Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.

Khalil Essani - Single Use Support

Khalil Essani

February 7, 2024

Monoclonal Antibodies

Solutions for mAb development and manufacturing

Monoclonal antibody development and manufacturing are highly specialized processes, demanding equally specialized equipment. We will discuss some essential tools and systems in this article.

BRMO

Brian Moloney

February 7, 2024

Monoclonal Antibodies

Safe handling of monoclonal antibodies: Best practices

Monoclonal antibodies bring along some special requirements in terms of safe handling. In this article, we will discover what these requirements are, and how they can be met.

Claus Exenberger - Single Use Support

Claus Exenberger

February 7, 2024

Monoclonal Antibodies

Steps in Monoclonal Antibody Production

From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production. 

Khalil Essani - Single Use Support

Khalil Essani

February 6, 2024

Monoclonal Antibodies

The 3 Most Overlooked Costs in Monoclonal Antibody Production

In the quest for efficient monoclonal antibody manufacturing, it's imperative to shed light on costs that are frequently underestimated. These costs can stem from various sources, including process development, high prices associated with biotherapeutics, and the evolving landscape of production technologies.

daniel-tischler

Daniel Tischler

February 6, 2024

Monoclonal Antibodies

Challenges in monoclonal antibody production

mAb production requires high levels of expertise and precision, as well as specialized equipment. Nonetheless, there are several challenges that manufacturers have to deal with.

Alexander Fuchs | Single Use Support

Alexander Fuchs

February 6, 2024

Monoclonal Antibodies

Antibody storage: preserving monoclonal antibodies

In many cases, antibodies need to be stored for varying time spans before further processing or administration. Hence, it is essential to mind the characteristic storage requirements of these valuable biologics.

Alexander Fuchs | Single Use Support

Alexander Fuchs

February 5, 2024

Monoclonal Antibodies

Solutions for automated aseptic filling of monoclonal antibodies

Filling monoclonal antibodies requires dedicated solutions that allow smooth and safe mAb processing. In this article, we will discuss some of the integral components in this procedure.

BRMO

Brian Moloney

February 5, 2024

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

Whitepaper: Automated Aseptic Filling

Read our Whitepaper about Automated Aseptic Filling in Pharmaceutical Manufacturing | Discover why automatic filling solutions are preferable to manual filling.