Freezing drug substances to ultra-cold temperatures is a standard step in biopharmaceutical manufacturing. Yet, beyond simply cooling, it’s the critical quality attributes (CQA), like product safety, consistency, and process efficiency, that trul...
In the biopharmaceutical sector, the utilization of F-Gases, also known as fluorinated greenhouse gases, is on a decline. However, the need for cryopreservation of drug substances will remain. In order to contribute to a more environmentally frien...
Pharma 4.0 is no longer a thing of the future. Industry 4.0 for biopharmaceutical manufacturing is here now. Innovative manufacturers are striving for operational excellence in as many areas of bioprocessing as possible. In return, they will bene...
Cryopreservation is a critical procedure that includes the cooling and preservation of frozen cells at extremely low temperatures. This process is fundamental in various scientific and medical applications, facilitating long-term storage withou...
State-of-the-Art Freeze/Thaw System Donated to NIBRT The National Institute for Bioprocessing Research and Training (NIBRT) announced in April 2024 the receipt of a donation of Single Use Support's Lab Scale freeze/thaw system. The collaboration b...
In the world of biopharmaceutical manufacturing, ensuring the integrity and stability of drug products is paramount. One of the significant challenges faced by manufacturers, especially those involved in mRNA production, is RNase contamination....
Definition of RNase Ribonuclease, commonly referred to as RNase, is an enzyme that catalyzes the degradation of RNA into smaller components. It is a ubiquitous enzyme found in all organisms. Due to its widespread presence and stability, RNase cont...
Shedding UV light on single-use bags The biopharmaceutical manufacturing sector is undergoing rapid transformation, with single-use technology becoming a fundamental aspect of efficient and safe production. Among the various components utilized...
As cell and gene therapies (CGT) continue to advance, single-use systems have become essential for maintaining the safety and effectiveness of these intricate biological products. These systems not only improve sterility but also simplify manufact...
Biologic manufacturing describes the process of producing medicine by the means of living organisms. Biotech and pharma companies make use of this approach to produce biologics like mAbs (monoclonal antibodies) or mRNA vaccines both at small an...
The number of FDA approved antibody-drug conjugates has rapidly risen in the last decade and promises to continue to do so. ADCs are very effective drugs used in the treatment of metastatic diseases and anticancer therapy. Many cancer patients cou...
Freezing biologics is an almost unavoidable step in the process of preserving and storing them for an extended period of time. After all, biologics encompass a diverse range of therapeutic products derived from living organisms. They include mo...
Antibody drug conjugates (ADCs) are a promising alternative for cancer therapy. Due to the targeting quality of the monoclonal antibody (mAb) in combination with a highly toxic payload drug, it becomes easier to target cancer cells without potenti...
