All articles

Cell Banking

What is the difference between cytotoxicity and cell viability?

Although there are significant differences between cytotoxicity and cell viability, they both are frequent concepts in cell biology and cell banking. We will discuss these two parameters in this article.

michael-muehlegger

Michael Mühlegger

July 26, 2023

Cell Banking

What is cell viability and cell proliferation?

Both cell viability and cell proliferation are important parameters in cell banking. In this article, we will shed light on these two concepts.

micheal-eder

Michael Eder

July 26, 2023

Single-use Consumables

Interview: Considerations for Sterilization of single-use assemblies

In an interview with single-use systems expert David Seifert, he compares sterilization methods and shares insights, benefits and outlooks in the field of single-use sterilization technology.

1640281789974

David Seifert

July 14, 2023

mRNA & LNPs

What is mRNA?

mRNA is the acronym for messenger ribonucleic acid – but there is much more to know about this fascinating molecule, as it is essential in elementary biological processes. In this article, we will give readers a brief explanation of what mRNA actually is and discuss its application in medicine as well as recent advances in mRNA technology.

micheal-eder

Michael Eder

July 6, 2023

mRNA & LNPs

The function of mRNA

In order for the genetic information encoded by DNA to become an accessible blueprint for protein production, mRNA is indispensable. In this article, we will provide a comprehensive definition of mRNA and illustrate its main functions.

micheal-eder

Michael Eder

July 6, 2023

mRNA & LNPs

mRNA Manufacturing – The 5 process steps of mRNA production

mRNA is a fundamental component of several biological processes, and its unique properties are used in different fields of medicine and research. mRNA manufacturing, however, is a complicated endeavor. In this article, we will take a detailed look at mRNA manufacturing and the advantages that come with single-use technologies.

daniel-tischler

Daniel Tischler

July 5, 2023

mRNA & LNPs

mRNA cold chain: considerations & solutions for safe handling

Meeting the temperature requirements of mRNA-based products is essential to maintain product efficiency and safety. Effective mRNA cold chain management is necessary, but comes with several challenges. In this article, we will discuss relevant considerations and innovative solutions in mRNA cold chain management.

micheal-eder

Michael Eder

July 5, 2023

mRNA & LNPs

Freezing mRNA: best practice

Considering the manifold applications of mRNA, it is essential to establish optimal freezing processes that maintain viability and effectiveness. In this article, we will compare different freezing methods for mRNA.

Alexander Fuchs | Single Use Support

Alexander Fuchs

July 4, 2023

mRNA & LNPs

Lipid nanoparticles: All you need to know about LNPs

After the first LNPs were approved by FDA in 2018, the whole field of LNPs as drug delivery systems has expanded rapidly. In the following article we will explore what qualifies lipid nanoparticles as one of the most promising pharmaceutical drug delivery systems and will take a closer look at their structure, applications and challenges connected with the manufacturing process.

michael-muehlegger

Michael Mühlegger

June 30, 2023

mRNA & LNPs

Filling, Filtering & Dispensing mRNA

As the demand for messenger RNA-based products continues to rise, efficient fluid management plays a crucial role in ensuring the high-quality production of mRNA drug products. This article is about challenges and the latest advancements in fluid management techniques, focusing on filling, filtering, and aliquoting mRNA during the manufacturing process.

BRMO

Brian Moloney

June 29, 2023

mRNA & LNPs

Filling & aliquoting LNPs in single-use bags

The use of lipid nanoparticles has gained significant attention due to their potential applications in drug delivery systems. In this article we explore the process of filling and aliquoting LNPs in single-use bags and highlight its significance and key considerations.

BRMO

Brian Moloney

June 28, 2023

mRNA & LNPs

Freezing LNPs & the impact on their long-term stability

Freezing is a significant process step in the manufacturing of LNP-based products. In this article, we will therefore take a look at the impact freezing has on lipid nanoparticles.

Alexander Fuchs | Single Use Support

Alexander Fuchs

June 26, 2023

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

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Whitepaper: Automated Aseptic Filling

Automated Aseptic Filling Unprecedented flexibility to filling well