mRNA & LNPs

Explore the fascinating world of mRNA and lipid nanoparticles (LNPs) through our insightful articles. Learn about their roles in modern medicine and cutting-edge research. Single Use Support provides innovative solutions for the transport and storage of mRNA and LNPs, ensuring their stability and effectiveness.

Featured Articles

The thawing process in drug substance management

mRNA & LNPs

Freezing LNPs & the impact on their long-term stability

Freezing is a significant process step in the manufacturing of LNP-based products. In this article, we will therefore take a look at the impact freezing has on lipid nanoparticles.

Alexander Fuchs

June 26, 2023

How to produce lipid nanoparticles (LNPs)

mRNA & LNPs

Lipid nanoparticle (LNP) manufacturing: Challenges & Solutions

Being promising tools in life sciences and medicine, lipid nanoparticles are drawing attention on their manifold advantages. In this article, however, we take a step back and discover how LNPs are produced. Solutions based on single-use systems for increasing quality and efficiency in production are also covered.

Brian Moloney

June 21, 2023

mRNA & LNPs

mRNA technology simply explained

New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce specific proteins. Nevertheless, the heightened demand for mRNA drugs leads to challenges for its production.

Daniel Tischler

June 15, 2023

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All articles about mRNA & LNPs

mRNA & LNPs

RNase Contamination – Challenges & Solutions

This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment

David Seifert

August 13, 2024

mRNA & LNPs

RNase: Ribonuclease Simply Explained

RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC

David Seifert

August 12, 2024

mRNA & LNPs

Single-use technology in mRNA manufacturing

MRNA manufacturing demands for highest accuracy, safety, and compliance. In this article, we will find out how single-use technologies can be used to achieve improvements for mRNA production and processing.

Brian Moloney

January 8, 2024

mRNA & LNPs

What is mRNA?

mRNA is the acronym for messenger ribonucleic acid – but there is much more to know about this fascinating molecule, as it is essential in elementary biological processes. In this article, we will give readers a brief explanation of what mRNA actually is and discuss its application in medicine as well as recent advances in mRNA technology.

Michael Eder

July 6, 2023

mRNA & LNPs

The function of mRNA

In order for the genetic information encoded by DNA to become an accessible blueprint for protein production, mRNA is indispensable. In this article, we will provide a comprehensive definition of mRNA and illustrate its main functions.

Michael Eder

July 6, 2023

mRNA manufacturing & advances with single-use technology

mRNA & LNPs

mRNA Manufacturing – The 5 process steps of mRNA production

mRNA is a fundamental component of several biological processes, and its unique properties are used in different fields of medicine and research. mRNA manufacturing, however, is a complicated endeavor. In this article, we will take a detailed look at mRNA manufacturing and the advantages that come with single-use technologies.

Daniel Tischler

July 5, 2023

mRNA & LNPs

mRNA cold chain: considerations & solutions for safe handling

Meeting the temperature requirements of mRNA-based products is essential to maintain product efficiency and safety. Effective mRNA cold chain management is necessary, but comes with several challenges. In this article, we will discuss relevant considerations and innovative solutions in mRNA cold chain management.

Michael Eder

July 5, 2023

mRNA & LNPs

Freezing mRNA: best practice

Considering the manifold applications of mRNA, it is essential to establish optimal freezing processes that maintain viability and effectiveness. In this article, we will compare different freezing methods for mRNA.

Alexander Fuchs

July 4, 2023

mRNA & LNPs

Lipid nanoparticles: All you need to know about LNPs

After the first LNPs were approved by FDA in 2018, the whole field of LNPs as drug delivery systems has expanded rapidly. In the following article we will explore what qualifies lipid nanoparticles as one of the most promising pharmaceutical drug delivery systems and will take a closer look at their structure, applications and challenges connected with the manufacturing process.

Michael Mühlegger

June 30, 2023

Facing challenges regarding lipid nanoparticles with single-use technology

mRNA & LNPs

Filling, Filtering & Dispensing mRNA

As the demand for messenger RNA-based products continues to rise, efficient fluid management plays a crucial role in ensuring the high-quality production of mRNA drug products. This article is about challenges and the latest advancements in fluid management techniques, focusing on filling, filtering, and aliquoting mRNA during the manufacturing process.

Brian Moloney

June 29, 2023

Filling of drug substance: 5 threats you should know

mRNA & LNPs

Filling & aliquoting LNPs in single-use bags

The use of lipid nanoparticles has gained significant attention due to their potential applications in drug delivery systems. In this article we explore the process of filling and aliquoting LNPs in single-use bags and highlight its significance and key considerations.

Brian Moloney

June 28, 2023

mRNA & LNPs

Freezing LNPs & the impact on their long-term stability

Freezing is a significant process step in the manufacturing of LNP-based products. In this article, we will therefore take a look at the impact freezing has on lipid nanoparticles.

Alexander Fuchs

June 26, 2023

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Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

Whitepaper_Controlled_Scalable_Freezing_SEP22

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

App Note: The Chilled Future of RNA Therapeutics Filling & Freezing Applications

Traditional and rigid manufacturing processes are not for Advanced Therapies. Since novel therapies push limits in biotechnology, life science needs to keep up with adequate process solutions around commercialization of these specific therapies. Yes, SARS-CoV-2 has largely boosted the acceptance of mRNA in vaccines. And RNA vaccines and therapeutics won’t stop to fulfil unmet medical needs. But biotechs and biopharma companies continuously advancing novel treatments while solution provider drive process optimization to increase efficiency. With different product characteristics come different challenges and risks for fluid management. Therefore, modular, and flexible technologies facilitate ATMPs (Advanced Therapy Medicinal Products) manufacturing. Adjustability of process solutions to different requirements and scenarios will satisfy the needs of biomanufacturing and biotechnology companies as well as CMOs and CDMOs along the journey from drug development to commercialization.