Biopharmaceutical Products

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All articles about Biopharmaceutical Products

Biopharmaceutical Products

Lentiviral vector manufacturing: Outdated or advanced gene therapy viruses?

Lentiviral vectors have become important tools in gene therapy, offering new opportunities for treating a wide array of diseases. Learn more about comparison with AAVs and how lentiviral vector manufacturing challenges – from plasmid design to aseptic filling and controlled freezing – can be solved to enhance overall manufacturing efficiency. 

BRMO

Brian Moloney

November 5, 2024

Biopharmaceutical Products

Oligonucleotide manufacturing – challenges & solutions

Oligonucleotide manufacturing. Optimizing fluid management, freezing & cold storage | Purification Oligonucleotides

michael-muehlegger

Michael Mühlegger

October 25, 2024

Biopharmaceutical Products

Oligonucleotides simply explained

What are oligonucleotides? Nucleic acid types | RNA oligonucleotides | DNA oligos | Types of Oligonucleotides

michael-muehlegger

Michael Mühlegger

October 25, 2024

Biopharmaceutical Products

DMSO: Freezing Cells

Freezing cells is a process that requires more than simply placing them in a freezer with dimethyl sulfoxide (DMSO). It is a precise and meticulous process, where precision and expertise are essential. The goal is to achieve high cell viability and therefore high yield for cell-based therapies or cell banking.

Khalil Essani - Single Use Support

Khalil Essani

October 11, 2024

Biopharmaceutical Products

RNase Contamination – Challenges & Solutions

This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment

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David Seifert

August 13, 2024

Biopharmaceutical Products

RNase: Ribonuclease Simply Explained

RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC

1640281789974

David Seifert

August 12, 2024

Biopharmaceutical Products

The Role of Single-Use Systems in Cell and Gene Therapies

Ensuring that cell and gene therapy products are shipped at cold temperatures with robust controls is even more important for cell & gene therapies than it is for more traditional biopharmaceutical products.

michael-muehlegger

Michael Mühlegger

July 8, 2024

Biopharmaceutical Products

Fluid management solutions for biosimilar production

In biosimilar production, fluid management takes on an overarching role, as it is encountered at several manufacturing steps. This is all the more reason to deal with efficiency in fluid management – which we will do in this article.

BRMO

Brian Moloney

May 14, 2024

Biopharmaceutical Products

Challenges in manufacturing biosimilars

The manufacturing process of biosimilars is a complex endeavor, accompanied by several challenges. We will discuss some of the biggest hurdles in this article, along with solutions to overcome them.

BRMO

Brian Moloney

May 14, 2024

Biopharmaceutical Products

The development process of biosimilars

The development process of biosimilars slightly differs from the one of their reference biologics. In this article, we will discuss each phase in detail.

micheal-eder

Michael Eder

May 13, 2024

Biopharmaceutical Products

Biomanufacturing: Process, steps and challenges in manufacturing biologics

As biologics have become a central pillar in today’s healthcare sector, their manufacturing process increasingly draws attention. In this article, we will discuss the process step by step, including challenges and possible ways to overcome them.

micheal-eder

Michael Eder

May 13, 2024

Biopharmaceutical Products

Efficient strategies for manufacturing biosimilars

Establishing both efficient and safe manufacturing processes for biosimilars requires planning, expertise, and state-of-the-art equipment. In this article, we will shed light on different steps in the manufacturing process and discuss ways to improve them.

micheal-eder

Michael Eder

May 8, 2024

Recommended Downloads

E-Book

Whitepaper: Freezing & Storage of Biopharmaceuticals at -80°C

In this publication we show that the initial price can be deceiving and there are significant additional costs during ongoing usage in the long term. Plate freezers ensure a complete, consistent, and fast freezing (and thawing) to ensure the quality of your high-valued drug substance is maintained, and through simple lifecycle analysis they outpace conventional options regarding total costs.

E-Book

Whitepaper: Homogeneity in Biopharmaceutical Aliquotation

Homogeneity of pharmaceuticals plays a major role in fluid management. Liquid drugs have different viscosities, degrees of sedimentation, and other varying properties, making it difficult to standardize the aliquotation of liquids. RoSS.PADL is a homogenizing solution with kneading and cooling functions for standardizing the mixing of biopharmaceuticals precedenting the dispensation into single-use bioprocess containers. This fully automated and hence standardized process ensures homogeneous distribution of the liquids in single-use bio process containers.

E-Book

Navigating 5 Overlooked Challenges in Bioconjugate Manufacturing

This guide for bioconjugate manufacturing with regards to fluid and cold chain management addresses challenges such as: protection against ADC toxicity, accuracy in fluid management, maintaining ADC stability after freeze-thaw cycles, transition from lab to commercialization, and cost considerations of equipment.