RoSS.FILL Bag - single use bag filling

Automated single-use aseptic bag filling system

RoSS.FILL Bag is a flexible automated single-use aseptic bag filling system for dispensing biopharmaceuticals. The fluid path is designed to be fully disposable and is able to accommodate a variety of sterile connection and disconnection options.

Automated sealing and stepping valves included for variable fluid control for fast filling + simple aseptic decoupling

RoSS.FILL Bag - single use bag filling and draining system machine
speed

Fast lead times

worldwide

Worldwide shipping

customer-service

Personal customer service

Our customers trust in us:

Fujifilm Diosynth

Moderna

AGC Biologics

Why is RoSS.FILL bag a reliable aseptic bag filling system?

In terms of reliability, RoSS.FILL Bag is an aseptic bag filling system that stands out with several characteristics: Not only is the fluid path fully disposable, but it is ready to accomodate various sterile connection and disconnection options for single use aseptic filling.

In addition, the single use filling system provides an automated sealing function, an automated stepper function is highly precise, with an accuracy of only +-10 ml for 10 liters, making RoSS.FILL bag an extremely reliable, user-friendly single-use aseptic bag filling machine.

Single use bag filling system RoSS.FILL

Features and Benefits of our aseptic bag filling machine

  • Volume: Up to 400 L per batch
  • Scalability: Option to attach a second filling rack for higher batch volumes
  • Fully automated filling and filtration system for single-use bags
  • Accuracy of +-10 mL for 10 liters with individual weighing cells
  • Hygienic Design: easy to clean surface thanks to improved design
  • Ease of use in operation / recipe driven processing
  • Modular system with separate control unit and pumping station as well as storage rack made up of RoSS trays
  • Integration of bulk filtration and differential pressure measurement
  • Option to take samples
  • Optional MES integration to DeltaV or other
RoSS.FILL filling and draining system for single-use bags

Advanced Sealer & Stepper Pinch Valve

2 functions in 1 device: Variable fluid control for fast filling + simple aseptic decoupling

Automated Sealing Function:

  • Dropless disconnection by sealing
  • No need for cumbersome post processing of metal seals and giving the benefit of removing sharp edges
  • Fully aseptically closed – no risk of leakage
  • Simple Aseptic Decoupling: safer, automated disconnection
  • The fully tested sealed tubings withstand a temperature of up to -190°C


Automated Stepper Function:

  • Closed or open or anywhere in between
  • Run your pump at 100% speed - allow the stepper to control the fill rate
  • Unprecedented levels of control in your fill recipe
  • Fastest filling rate
  • Fill several bags in parallel
RoSS.FILL_Sealer-Stepper Valve Rack_2
Sealer Valve_3

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FAQ on Single-use bag filling

What is an aseptic filler?

Aseptic fillers are aseptic filling machines that are used in the pharma industry in order to maintain a sterile environment in the process of fluid management. They are made to prevent the processed drug products from being contaminated with germs while they fill them into sterilized containers before sealing these. 

With the aim to facilitate a secure, flexible and reliable filling process, Single Use Support has developed the RoSS.FILL platform, with single use filling machines both for lab and bulk scale production.

What is an aseptic bag?

An aseptic bag is a germ-free container that is used within the supply chain of several drug products. Sufficiently sealed, aseptic bags like Single Use Support’s IRIS Single-use bioprocess containers are designed to prevent the products that are stored within them from being contaminated.

Aseptic bags need to be sterilized before they can be used; the four main ways to do so are:

  • sterilization by heat
  • sterilization by radiation
  • mechanical sterilization
  • chemical sterilization

What is single use bag filtration?

Single use bag filtration is usually performed during the process of single use bag filling and is vital to guarantee product quality. It is carried out to remove impurities from the processed drug substances when they are filled into single use bags.

What are the requirements in the aseptic area?

The aseptic area requires maintaining a sterile environment for drug materials all the way from the manufacturing site to the place of application. This implies the necessity of specialized equipment that accompany this complex process as soon as the drug product is sterilized, including aseptic filling machines and tubing, sterile containers and a sterile filling environment. 

Additionally, the containers have to be sufficiently sealed in order not prevent contamination along the supply chain of the drug product.

What is the difference between aseptic and septic?

While describing something as septic implies that it is contaminated with germs and potentially harmful or – in the case of tissue – damaged, aseptic means the opposite, as a consequence of adding the prefix a. Aseptic is normally used to describe a process that is kept germ-free, and has a similar meaning as the word sterile; the latter, though, is most commonly used to describe a specific environment that is free of germs.

What is an aseptic filling machine?

An aseptic filling machine is part of the supply chain of various goods, including several drug products. It is designed to facilitate the filling of drug products into pre-sterilized containers, before these are sealed.

Considering the need for highest accuracy within this process, aseptic filling machines need to be extremely reliable; Single Use Support has therefore developed the RoSS.FILL platform with high quality aseptic filling machines for different fields of application.