• Image of aseptic filling system RoSS.FILL Bag on a transparent background.

Aseptic filling system | RoSS.FILL Bag

Aseptic filling system | RoSS.FILL Bag

RoSS.FILL Bag is a flexible automated aseptic filling machine for the aliquotation and dispensing of bulk drug substance (BDS) into single-use bags. The system for aseptic filling and sterile filtration is highly precise, making RoSS.FILL Bag an extremely reliable, user-friendly single-use bag filling machine.

Request a quote
View full details
Green icon of a water droplet and an arrow on a transparent background demonstrating scalability
Up to 400L+/Batch
Green icon of a checkmark symbol inside a target on a transparent background demonstrating highest accuracy
Highest accuracy
Green icon demonstrating fast throughput in biomanufacturing
Fast throughput

Aseptic bag filling: Why to rely on RoSS.FILL Bag?

In terms of reliability, RoSS.FILL Bag is an aseptic bag filling system that stands out with several characteristics: Not only is the fluid path fully disposable, but it is ready to accomodate various sterile connection and disconnection options for single use aseptic filling.

In addition, the advanced sealing pinch valves, including an automated stepper, sealing and perforation fuction enable a fast and efficient filling process with an easy and dropless disconnection.

Contact us

Our customers trust in us:

Reference Logo
Reference Logo
Reference Logo

Features and benefits of our aseptic filling system for single-use bags

  • A close-up image of an operator handling an aseptic filling system for single-use bags.

    • Volume: Up to 400 L per batch
    • Scalability: Option to attach a second filling rack for higher batch volumes
    • Fully automated filling and filtration system for single-use bags
    • Accuracy of ±20g for 0.2 to 5.0kg & ±25g for 5.0 to 20kg
    • Ease of use in operation / recipe driven processing
    • Bag & Connector agnostic setup
    • Modular system with separate control unit and pumping station as well as storage rack made up of RoSS trays
    • Integration of bulk filtration and differential pressure measurement
    • Option to take samples
    • Optional MES integration to DeltaV or other
    Get in touch now

Advanced sealing pinch valves

Single Use Support‘s filling platforms are equipped with the next-gen, in-house developed pinch valves designed to accelerate the filling process and enable operator-free aseptic decoupling of single-use bags.

  • Sterile tube sealing:

    • Heat-sealing for TPE tubing
    • RF-sealing for PVC tubing
    • Operator-free aseptic decoupling
    • Fully aseptic closure – no risk of leakage
    • No risk of contamination

    Paralell filling:

    • Due to the fully variable position of the valve multiple bags can be filled simultaneously
    • Enables increased filling speed
    • Pump can always be operated at the max. allowed speed

    Tear-off feature:

    • The perforation created during heating tear-off allows easy disconnection of the tubing by hand
    • Easy separation of the bag from the rest of the manifold
    • Eliminates the need for post-processing of metal seals and removal of sharp edges
    • No external tools required

    Get in touch now
  • Image of a sealing pinch valve for operator-free aseptic decoupling of single-use bags.

Downloads

Preview of datasheet for RoSS.FILL Bag fill-filtration unit by Single Use Support
Datasheet: RoSS.FILL Bag
Preview of datasheet for RoSS.FILL Bag fill-filtration unit by Single Use Support
Datasheet: RoSS.FILL Bag
 
Preview of Single Use Support's whitepaper about automated filling with RoSS.FILL
Whitepaper: RoSS.FILL - Automated aseptic filling
Preview of Single Use Support's whitepaper about automated filling with RoSS.FILL
Whitepaper: RoSS.FILL - Automated aseptic filling
 

Why use aseptic filling at all?

  • Fluid transfer of biopharmaceuticals, particularly when small volumes are to be dispensed into a primary packaging, is typically done in biocabinets or isolators. Manual processing, as performed in isolators, is prone to error and contamination. 

    The FDA and Annex 1 of cGMP recommend automated equipment that supports a closed system for aseptic filling. With solutions such as RoSS.FILL Bag, aseptic filling and sterile filtration into primary packaging can be performed more efficiently and with reduced risk of contamination through effective sterilization methods

    RoSS.FILL Bag outperforms other aseptic filling platforms with its filling accuracy, its ease-of use and high throughput. It can be scaled down to smaller volumes and bags and up to fill bulk drug substances with changing the attached filling racks.

  • Close-up image of an operator interacting with a manifold setup on a RoSS.FILL Bag.

More solutions

More information

Increasing Patient Safety: Risk assessment for small volume fluid management

Increasing Patient Safety: Risk assessment for small volume fluid management

Advanced cell and gene therapies, such as autologous therapies, exhibit certain specific requirements. The scale of such therapies is very different from what we typically see in conventional biopharmaceutical manufacturing processes in commercial...

Jonathan Haider
Jonathan Haider
Aseptic bag filling – 5 critical considerations

Aseptic bag filling – 5 critical considerations

Aseptic bag filling is a process that is very important to the biopharma industry. For the process, aseptic bag filling machines are used specifically.  The technique of aseptic packaging is applied when sterilization of medical applications is no...

Jonathan Haider
Jonathan Haider
Fluid management systems: 7 considerations to be made

Fluid management systems: 7 considerations to be made

Automated fluid management systems have gained a lot of popularity in the recent past. Production processes in biopharma have never been more competitive. New advances and research in gene and antibody therapy have called for more streamlined prod...

Michael Mühlegger
Michael Mühlegger

Send a request