Parallel controlled freezing and thawing of thousands of liters in biopharmaceutical manufacturing processes. The extra large scale freezing platform system is an automated plate-based freeze-thaw unit for liquid substances including vaccines, media, buffer solutions or other drug substances. The established RoSS.pFTU platform system is compatible with 10x50L single-use bags from any vendor.
Advantages of controlled plate-freezers
Dark blue spots indicate a higher cryoconcentration.
Fast & controlled freezing with a plate freezer enables a homogeneous freezing result.
Description
Plate-based Freeze & Thaw platform system for controlled freezing and thawing of extra large volumes and bulk drug substances (BDS) in biopharma manufacturing processes:
- Capacity: 500L nominal volume per Batch (10x50L Bags)
- Flexible Primary Packaging: Choose any 50L single-use bag of your choice
- Freezes down to -90°C
- Thawing with integrated shaker function
- Technology: Plate-based freezer for homogeneous freezing of your product
- GMP-compliant, automated, at highest possible speed and accuracy
RoSS Shell for Protection & Secondary Packaging
- For best protection and optimized homogeneous freezing we recommend the use of RoSS shells for your single-use bags
- Simple loading and unloading of the RoSS shells with a specific external rack
Our customers trust in us:
Advantages of RoSS.PFTU over other solutions in the industry
CryoVessel Platform 1 | Blast-Freezer Platform 2 | Plate-Based Freeze Thaw Platform RoSS.PFTU XL | Comments | |
| Fast Freezing | × | × | ✅ | The RoSS.pFTU XL achieves controlled freezing to -80°C in less than 10 hours. |
| Vendor-agnostic primary packaging | ⁓ | × | ✅ | Full freedom on choice of your primary packaging supplier to ensure a closed system. |
| Modularity & Scalability | × | × | ✅ | Scalable freezing with the RoSS.pFTU plate-freezers from 1L up 500L nominal volume per batch |
| Minimum Manual Handling | ⁓ | ⁓ | ✅ | Fully automated freezing process & simple loading/unloading of the palette-size racked |
| Product Viability | × | × | ✅ | Higher product quality with controlled plate-freezing preventing the effect of cryoconcentration . |
The ROI of Bulk Freezing with Plate Freezers
The switch from cryovessels to plate-based freeze & thaw single-use technologies is, not least, a matter of costs. To determine the return on investment (ROI), different cost drivers were identified and evaluated. Discover the comparison of cryovessels, blast freezers and plate-based freezers in this case study.
