RoSS.pFTU XL | Plate Freeze & Thaw

Parallel controlled freezing and thawing of thousands of liters in biopharmaceutical manufacturing processes. The extra large scale freezing platform system is an automated plate-based freeze-thaw unit for liquid substances including vaccines, media, buffer solutions or other drug substances. The established RoSS.pFTU platform system is compatible with 10x50L single-use bags from any vendor.

Product Overview_RoSS.pFTU XL_3
temperature-control

Down to -80°C / -112°F

controlled-freezing-thawing

Controlled rate freezing & thawing

capacity

Up to 500L

Advantages of controlled plate-freezers

Dark blue spots indicate a higher cryoconcentration. 
Fast & controlled freezing with a plate freezer enables a homogeneous freezing result.

Advantages of controlled plate-freezers-Grafik

Description

Plate-based Freeze & Thaw platform system for controlled freezing and thawing of extra large volumes and bulk drug substances (BDS) in biopharma manufacturing processes:

  • Capacity: 500L nominal volume per Batch (10x50L Bags)
  • Flexible Primary Packaging: Choose any 50L single-use bag of your choice
  • Freezes down to -90°C
  • Thawing with integrated shaker function
  • Technology: Plate-based freezer for homogeneous freezing of your product
  • GMP-compliant, automated, at highest possible speed and accuracy
SingleUseSupport_Pharma Innovation Awards_2023_RoSS.pFTU XL_Banner

RoSS Shell for Protection & Secondary Packaging

  • For best protection and optimized homogeneous freezing we recommend the use of RoSS shells for your single-use bags
  • Simple loading and unloading of the RoSS shells with a specific external rack
RoSS shell 50L with RoSS.pFTU XL-4

Our customers trust in us:

Rentschler Biopharma SE

Lonza

SCHOTT Pharma

Advantages of RoSS.PFTU over other solutions in the industry

 

CryoVessel Platform 1 

Blast-Freezer Platform 2

Plate-Based Freeze Thaw Platform

RoSS.PFTU XL 

Comments

Fast Freezing

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The RoSS.pFTU XL achieves controlled freezing to -80°C in less than 10 hours.

Vendor-agnostic primary packaging

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Full freedom on choice of your primary packaging supplier to ensure a closed system. 

Modularity & Scalability 

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Scalable freezing with the RoSS.pFTU plate-freezers from 1L up 500L nominal volume per batch

Minimum Manual Handling

Fully automated freezing process & simple loading/unloading of the palette-size racked

Product Viability 

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Higher product quality with controlled plate-freezing preventing the effect of cryoconcentration . 

     

The ROI of Bulk Freezing with Plate Freezers

The switch from cryovessels to plate-based freeze & thaw single-use technologies is, not least, a matter of costs. To determine the return on investment (ROI), different cost drivers were identified and evaluated. Discover the comparison of cryovessels, blast freezers and plate-based freezers in this case study.

Case Study_RoSS.pFTU_The ROI of Bulk Freezing with Plate Freezer

Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

Filesize: 1.64 MB – Mime-Type: application/pdf

Data sheet

Datasheet_RoSS.pFTU XL

Datasheet RoSS.pFTU XL

Filesize: 0.58 MB – Mime-Type: application/pdf

Whitepaper: Scalable Freezing & Thawing of Pharmaceutical Bulk

Whitepaper: Scalable Freezing & Thawing of Pharmaceutical Bulk

Filesize: 1.13 MB – Mime-Type: application/pdf

Whitepaper_Controlled_Scalable_Freezing

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Filesize: 1.96 MB – Mime-Type: application/pdf

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More information

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Whitepaper: How controlled freezing enables scalability

In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.

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It is not easy to choose the right technology when it comes to developing biopharmaceutical drug products! It’s important for frozen storage and transport solutions to be safe and cost-effective at the same time, especially as drugs transition from R&D through clinical trial and to higher volume production.
 

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