RoSS.pFTU Large-Scale

Freeze-Thaw | Up to 220L

Our large scale freezing platform system is a plate-based freeze-thaw unit for any scale and batch size. The established RoSS.pFTU large scale is compatible with single-use bags of all sizes and manufacturers. 

The hybrid solution offers freeze-thaw capabilities for bags and bottles up to 220L in one platform.  

RoSS PFTU_Large Scale_Freeze-Thaw Platform

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3SBio Inc.

The combination of a bag agnostic robust secondary packaging (RoSS®) and the scalable plate based freeze/thaw technologies convinced us to select Single Use Support. It not only matches all our requirements, it is also safe, easy to navigate and flexible to single use bags from any supplier.


Thanks to a fortunate coincidence, we got in touch with Single Use Support. Not only have we found a more than solid single-use solution for our main problem thanks to their product RoSS®, but we now have access to a clever and 100% safe drug substance logistics system.


Having partners such as Single Use Support in place will be one of many essential components as we scale our operations to deliver high-quality programs and vector production services to our clients.


Plate-based Freeze & Thaw platform system for freezing and thawing of larger volumes of drug substances, protected by RoSS shells

  • Capacity up to 220 L and more, depending on bag type
  • Usage for mid to large scale batch sizes. Scale-up for late phase studies or commercial production
  • Single-Use Bag independent: any bag vendor, any size
  • For best product protection we recommend the use of protective RoSS shells for your single-use bags
  • Hybrid: Freeze-thaw of bags and bottles in same platform
  • Best product stability results for mABs and BDS
  • GMP-compliant, automated, at highest possible speed and accuracy
  • Freezes down to -90°C

More solutions


RoSS.pFTU Lab-Scale | Freeze-Thaw

1mL-5L: Compatible with single use bags of all sizes and manufacturers. Our lab scale freezer is the perfect solution for studies conducted in labs and, above all, if you want to start a controlled and scalable freezing process.


RoSS.pFTU Mid-Scale | Freeze-Thaw

Up to 70L: Our mid scale freezer is a plate-based Freeze/Thaw unit designed for RoSS shells, to protect your preferred single-use bag during cryogenic applications. 

RoSS.pFTU mid scale is compatible with single-use bioprocess containers of all sizes and manufacturers and shows best product stability results for your biopharmaceuticals up to 70L. 


RoSS.FRDG | Ultra Cold Storage

RoSS.FRDG is a storage freezer for frozen drug substances in different sizes. It keeps the desired set point temperature down to -80°C. RoSS.FRDG is compatible with RoSS Shells, stackable itself, fully moveable and shippable. 


ROSS.SHAK | Shaker

RoSS.SHAK is your reliable shaker to regain highest quality and homogeneity of your biopharmaceuticals.

RoSS.SHAK enables constant shaking of your protein to regain homogeneity and product quality after freezing. Shakes up to 70L per run in 3 pre-defined speeds.


RoSS.PADL | Homogenizing Solution

RoSS.PADL is a scalable platform for cooling your single-use bag whilst gently massaging it to ensure there is a homogenous mixture of the solution. With the RoSS.PADL multiple cooling and massaging mechanisms can be placed side by side with one control system.

More information


Whitepaper: How controlled freezing enables scalability

In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.

RoSS_pFTU_Freeze-Thaw Platform_Single Use Support

Comparison of the freeze/thaw processes with single use and stainless steel

Case - study: Comparison of the freeze/thaw processes with single use and stainless steel


Introducing the next level of single-use freezing and thawing technologies

While the auto load function is a fantastic new tool, the well-established utilization of advanced single use technologies facilitates a safe and protected handling of highly valuable and sensitive drug substances throughout the entire process. The RoSS.pFTU freeze thaw platform contributes to a safe journey and warrants the bottle’s or single use bag’s intact arrival at its final destination, keeping its precious contents protected from biocontamination and other damages. Furthermore, the plate freezer unit is scalable for volumes of up to 200 l and offers the option of user-specific regulation and adaptation.


Single-use technology & the implementation in biopharma

Single-use technologies, which reduce the risk of cross-contamination of high-quality bulk drug substances, are becoming increasingly popular in the pharmaceutical industry. You can find out the reason for this in the blog post!

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