RoSS.pFTU Large-Scale | Plate Freeze & Thaw

Our large scale freezing platform system is a plate-based freeze-thaw unit for any scale and batch size. The established RoSS.pFTU large scale is compatible with single-use bags of all sizes and manufacturers. 

The hybrid solution offers freeze-thaw capabilities for bags and bottles up to 400L and beyond.  

RoSS.pFTU large-scale
temperature-control

Down to -80°C / -112°F

controlled-freezing-thawing

Controlled rate freezing & thawing

capacity

Up to 400L

Advantages of controlled plate-freezers

Dark blue spots indicate a higher cryoconcentration. 
Fast & controlled freezing with a plate freezer enables a homogeneous freezing result.

Advantages of controlled plate-freezers-Grafik

Description

Plate-based Freeze & Thaw platform system for freezing and thawing of larger volumes of drug substances, protected by RoSS shells

  • Capacity up to 400L and more, depending on bag type
  • Usage for mid to large scale batch sizes. Scale-up for late phase studies or commercial production
  • Single-Use Bag independent: any bag vendor, any size
  • For best product protection we recommend the use of protective RoSS shells for your single-use bags
  • Hybrid: Freeze-thaw of bags and bottles in same platform
  • Best product stability results for mABs and BDS
  • GMP-compliant, automated, at highest possible speed and accuracy
  • Freezes down to -90°C

Our customers trust in us:

Rentschler Biopharma SE

Lonza

SCHOTT Pharma

RoSS.LODR open loading single-use shell

RoSS.LODR | Foldable gripper arm

RoSS.LODR is a mobile and foldable gripper arm that ensures ergonomic handling during loading or unloading activities. RoSS.LODR supports a safe working environment and can significantly reduce work related repetitive strain injuries.

RoSS PFTU_Large Scale_Freeze-Thaw Platform_Hybrid

RoSS.pFTU Large-Scale Hybrid | Freeze-Thaw

The Hybrid Freeze and Thaw Platform freezes and thaws larger volumes of drug substances in both single-use bioprocess containers and bottles all in one. RoSS.pFTU large scale with its hybrid option is compatible with single-use bags and bottles from all manufacturers and of all sizes up to 400L and beyond.

Article: Walking on Thin Ice - Controlled Freezing & Thawing of APIs

Read Single Use Support's article, published on Cell & Gene Therapy Insights, why it is important to adapt both freezing and thawing processes to the characteristics of the protein or active pharmaceutical ingredient for cold chain storage and shipment. Controlled freezing and thawing facilitates consistent product quality during the fluid management processes involved in manufacturing. 

CGTI 2022 Controlled Freezing-Thawing of Pharmaceutical Active Molecules

CGTI Podcast Interview: Controlled Freezing-Thawing of Pharmaceutical Active Molecules

Filesize: 2.6 MB – Mime-Type: application/pdf

Data sheet

Datasheet_pFTU_LargeScale

Datasheet RoSS.pFTU Large Scale

Filesize: 1.78 MB – Mime-Type: application/pdf

Whitepaper: Scalable Freezing & Thawing of Pharmaceutical Bulk

Whitepaper: Scalable Freezing & Thawing of Pharmaceutical Bulk

Filesize: 1.13 MB – Mime-Type: application/pdf

Datasheet RoSS.pFTU Hybrid Freezing for Bags & Bottles

Hybrid Freezing Brochure - Bags and Bottles

Filesize: 1.35 MB – Mime-Type: application/pdf

Whitepaper_Controlled_Scalable_Freezing

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Filesize: 1.96 MB – Mime-Type: application/pdf

More solutions

Laboratory freezer RoSS.PFTU Lab Scale

RoSS.pFTU Lab-Scale | Plate Freeze & Thaw

1mL-10L: Laboratory freezer, compatible with single use bags of all sizes and manufacturers. Our lab freezer is the perfect solution for studies conducted in labs and, above all, if you want to start a controlled and scalable freezing process.

Down to -80°C / -112°F
Up to 10L
Controlled rate freezing & thawing
ross-pftu-mid-scale

RoSS.pFTU Mid-Scale | Plate Freeze & Thaw

Up to 100L: Our mid scale freezer is a plate freezer and thaw unit designed for RoSS shells, to protect your preferred single-use bag during cryogenic applications. 

RoSS.pFTU mid scale is compatible with single-use bioprocess containers of all sizes and manufacturers and shows best product stability results for your biopharmaceuticals up to 100L. 

Down to -80°C / -112°F
Up to 100L
Controlled rate freezing & thawing
RoSS.FRDG-Rendering

RoSS.FRDG | Ultra Cold Storage Freezer

RoSS.FRDG is an ultra cold storage fridge for frozen drug substances in different sizes. The ultra cold freezer keeps the desired set point temperature down to -75°C. RoSS.FRDG offers highest storage density, is fully movable and can be modularly adapted to your individual needs.

ross-shak-shaker

ROSS.SHAK | Shaker

RoSS.SHAK is your reliable shaker to regain highest quality and homogeneity of your biopharmaceuticals.

RoSS.SHAK enables constant shaking of your protein to regain homogeneity and product quality after freezing. Shakes up to 70L per run in 3 pre-defined speeds.

RoSS.PADL_Rendering_2

RoSS.PADL | Homogenizing Solution

RoSS.PADL is a scalable massaging platform for achieving a uniform mixture in
single-use bags. With integrated cooling and heating, it maintains optimal temperatures
consistently.

Cryogenic Freezer RoSS LN2F

RoSS.LN2F | Cryogenic Freezer

RoSS.LN2F is a powerful cryogenic controlled rate freezer for temperatures down to -170°C/-274°F. An enclosed LN2 system and our innovative direct injection system ensure no direct exposure and no mechanical compressors are needed. This ensures a safe, low-maintenance and energy-saving handling.

Down to -170°C / -274°F
Increased Cell Viability
Down to < 250mL/ Bag

More information

Freeze & Thaw

Whitepaper: How controlled freezing enables scalability

In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.

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Michael Eder

February 15, 2022

Freeze & Thaw

Efficient freezing and thawing of vaccines with single-use technologies

The global distribution of any medical substance requires more than what meets the eye. Before a vaccine can finally be shipped, it needs to be safely processed and contained. Single use technologies offer a number of advantages that cover the entire biopharmaceutical process, including development, manufacturing and logistics.

micheal-eder

Michael Eder

December 21, 2020

Single-use Technology

Single-use technology & the implementation in biopharma

Single-use technologies, which reduce the risk of cross-contamination of high-quality bulk drug substances, are becoming increasingly popular in the pharmaceutical industry. You can find out the reason for this in the blog post!
 

micheal-eder

Michael Eder

April 30, 2020

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