Fill & Filtration

Aseptic Bag & Bottle Filling

RoSS.FILL is a fully automated single-use bag filling & filtration system. The platform is fully scalable and enables maximum flexibility for both the aseptic filling and draining process. It is possible to fill unlimited volumes per batch with a speed of up to 300 liters per hour. 

The entire filling process is fully disposable, thus warranting an absolutely sterile fill process. For further productivity improvements check out our pinch valve innovation.


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RoSS FILL_Bag_Fill & Drain Platform

RoSS.FILL Bag | Fill-Filtration

RoSS.FILL is a flexible automated single-use technology for dispensing biopharmaceuticals into single-use bags. The fluid path is designed to be fully disposable and is able to accommodate a variety of sterile connection and disconnection options.


RoSS.FILL Bottle | Fill-Filtration

The fully automated RoSS.FILL platform enables worry-free filling and filtration of your liquid drug and non-drug substances into bottles. With its high filling accuracy, the platform provides continuous filling for up to 6 racks at the same time as closed system, no limitations in volume.


RoSS.FILL CGT | Fill-Filtration | 10mL-1000mL

Fully automated platform system for aseptic filling of multiple small single use bags. Special designed for use in cell & gene therapies with batch sizes at low volumes. With its high filling accuracy, the platform provides filling for up to 36 bags with one rack - having the option to attach more racks.

RoSS Fill-Lab Scale_Fill & Filtraton Platform

RoSS.FILL Lab Scale | Fill-Filtration | 10mL-1000mL

Accuracy is key: Fully automated platform system for aseptic filling of up to 12 single-use bags in standard configuration and is extendable to higher bag quantities. Most suitable for filling small volumes in cell & gene therapies or seed train intensification.


RoSS.DRAI | Drain

Drain your single use bags at Fill & Finish site. This standalone draining rack enable controlled fluid flow while draining single-use bags. Connected peristaltic pumps enable lowest holdup volume. Multiple racks can be attached for simultaneous and continuous pooling thanks to inclination of all shelves. All disconnection types possible.


RoSS.LIQU | 3D Single-Use Bag Totes

RoSS.LIQU is a smart rigid tote to protect 3D single-use bags with large volumes of up to 1000L for shipping applications. This robust stainless steel transport container is re-usable and offers a sustainable solution for single-use bag shipments compared to plastic alternatives.

Our customers trust in us:

3SBio Inc.

The combination of a bag agnostic robust secondary packaging (RoSS®) and the scalable plate based freeze/thaw technologies convinced us to select Single Use Support. It not only matches all our requirements, it is also safe, easy to navigate and flexible to single use bags from any supplier.


Thanks to a fortunate coincidence, we got in touch with Single Use Support. Not only have we found a more than solid single-use solution for our main problem thanks to their product RoSS®, but we now have access to a clever and 100% safe drug substance logistics system.


Having partners such as Single Use Support in place will be one of many essential components as we scale our operations to deliver high-quality programs and vector production services to our clients.


What makes the Fill & Filtration System so special?

Fully automated

Fully automated filling and draining system for single use bags or bottles. With a filling speed of up to 300 liters per hour, the RoSS® units on the rack are filled in a GMP-compliant computerized system.

Unrestricted Flexibility

Not only the option to attach additional bag or bottle filling racks to enlarge the batch volume size, but also flexibility in consumables is limitless. RoSS.FILL allows users to attach different manifold systems, pump and sampling tubings, bulk filtration filters and bag.

Unrestricted Scalability

RoSS.FILL opens doors to unprecedented scalability in terms of both, number of bags and size of bags for both. Continuous filling thanks to seamless manifold changes and the option to attach a second filling rack to the control unit allows unlimited volumes per batch. The scalability is limitless.

Unrivalled throughput and speed

Up to 300 liters of bulk drug substance within 60 minutes helps the industry to skyrocket the efficiency and creates resources to improve the performance whilst reducing product loss through a closed and automated process system. On top of that, holdup volume is limited to only few ml due to the smart manifold design and construction of the platform.

How does RoSS.FILL work?

RoSS.FILL is a flexible platform for the allocation and distribution of liquid drug substance in single-use bioprocess containers that are integrated in the protective RoSS® shell system. The liquid path is fully disposable, and can accommodate a multitude of sterile compound- and segregation options.

With a filling speed of up to 300 liters per hour, the RoSS® units on the rack are filled in a fully automated manner. Single-use bags of all established manufacturers and of different sizes and capacities are compatible. The scalability is limitless.

Fully automated, effective filling & draining process – what more could one wish for?

Our Single Use Filtration System

Our single use filtration system now offers a new feature: An optional choice to integrate supplier-independent filters has been added to the RoSS.Fill platform in order to further enhance the speed and reliability of bulk drug substance production. In an environment as sterile, complex and fast-paced as the pharmaceutical industry, the advantages of single use filters are clear:

Easy handling combined with the omission of tedious cleaning and maintenance work should be enough to convince any player in the industry; add to that inexpensive hardware costs and it makes absolute sense to add filters as a new component in the range of sterile compound and segregation options to the fully automated platform. Whether you are looking to reduce bioburden during cell harvesting or want to influence viral vectors in terms of their effect, the RoSS.FILL system now also offers you a filtration option, thus covering the entire biopharmaceutical logistics process. With sufficient filter surface area and a choice of pore sizes for different substances and volumes, the integrable filters are yet another key feature of our single use filtration system.


Data sheets

Click here to download technical product data sheets and design videos.

More solutions

RoSS PFTU_Large Scale_Freeze-Thaw Platform

Freeze & Thaw platform

The Single Use Support freeze-thaw platforms provide insular solutions for the freeze/thaw processes of each clinical phase. Our new freeze-thaw units are fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production.


MITS.2D | Integrity Testing System

Everything else is like “hoping that all goes well.”
With a patented system, MITS.2D tests single use bags with a capacity of up to 20 liters in less than 60 seconds to make sure they are 100% intact.


RoSS® Shell | Protecting single-use bags

The safest transport solution for all available single-use bioprocess containers. Robust. Scalable. Single-use bag independent.


IRIS Manifold | Single-Use Assemblies

As an expert in single-use solutions, we have made it our goal to deliver your custom single-use manifolds within 14 days. Prevent downtime and ensure an uninterrupted supply chain in compliance with GMP and regulatory requirements with our single-use systems using silicone tubing.

More information


All parts at a glance of Single-use tubing assemblies

Are you switching your operation to single-use tubing assemblies? In the following, we show you more about the separate components that single-use tubing assemblies and manifolds are made up of and their specific functions.


5 critical considerations for aseptic bag filling

Aseptic bag filling is a process that is very important to the biopharma industry. This article will give you the basics of aseptic bag filling, highlight the most critical factors of the technique and discuss key considerations pertaining to the commercial use of aseptic bags.

silicone-tubings-monifolds-1 (1)

Single-Use Assembly Tubing: Medical Tubing Manufacturers

An overview of manufacturers and its brands of single-use tubings for biopharmaceutical fluid management.

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