Cryogenic Freezer

Cryogenic freezing down to -180°C/-292°F | RoSS.LN2F

RoSS.LN2F is a powerful cryogenic controlled rate freezer for temperatures down to -180°C/-292°F. An enclosed and innovative platform system for dosed freezing for cell and gene therapies enables no direct exposure and no mechanical compressors are needed. This ensures a safe, low- maintenance and energy-saving handling.

Cryogenic Freezer RoSS LN2F
speed

Fast lead times

worldwide

Worldwide shipping

customer-service

Personal customer service

Advantages of the cryogenic freezer

  • Freeze your substance of high value in any single-use bioprocess container*
  • Fully automated & controlled
  • Fully Scalable
  • At highest possible speed & accuracy
  • Any freeze recipe of your choice
  • For best product stability results

*protected by RoSS.KSET and designed to your preferred bag

RoSS LN2F cryogenic freezer

Controlled cryogenic freezing with RoSS.LN2F

  • Controllable cooling rates in chamber from 0.5 to -99 K/min
  • Cooling/freezing rates in bags are adjustable, from 0.5 to 20 K/min
  • Starting from LPTF (last point to freeze) to –160°C/-256°F
  • Cooling/freezing performance based on innovative, controllable LN2 injection system
  • Adjustable phase transition time for higher product safety
  • Innovation is based on the fast cooling of chamber and subsequent continuous LN2 injection (makes system controllable and economically in operations)
RoSS LN2F cryogenic freezer example freeze curve

Our customers trust in us:

3SBio Inc.

The combination of a bag agnostic robust secondary packaging (RoSS®) and the scalable plate based freeze/thaw technologies convinced us to select Single Use Support. It not only matches all our requirements, it is also safe, easy to navigate and flexible to single use bags from any supplier.

Lonza

Thanks to a fortunate coincidence, we got in touch with Single Use Support. Not only have we found a more than solid single-use solution for our main problem thanks to their product RoSS®, but we now have access to a clever and 100% safe drug substance logistics system.

Genezen

Having partners such as Single Use Support in place will be one of many essential components as we scale our operations to deliver high-quality programs and vector production services to our clients.

Cryogenic storage as an essential component in modern life sciences

Along with autoclaves, centrifuges, laboratory freezers, incubators, refrigerators and ultra-low temperature freezers (ult freezers), cryostorage and (consequently) cryogenic freezers have become indispensable as lab equipment for many researchers, healthcare providers and drug product manufacturers.

Liquid nitrogen freezers like the RoSS.LN2F, made of stainless steel and with a temperature range that goes down to as low as -180° C are used when stem cells, gene therapies, cell culture microplates or several reagents and new products need to be prepared for long-term storage under cryogenic temperatures.

Sample storage of a few vials or pipettes is equally important as greater amounts of biologics by the means of a -180° C cryogenic freezer.

Not only for shippers, storage capacity in liquid nitrogen storage is essential, since cost effectiveness and high efficiency are necessary to be achieved; furthermore, user-friendliness in terms of easy access or intuitive operation via touch screen are also factors to be considered when choosing the right cryogenic freezing device.

More solutions

RoSS.FILL CGT

RoSS.FILL CGT | Fill-Filtration

10mL-500mL: Fully automated cell and gene filling machine system for aseptic filling of multiple small single use bags. Special designed for use in cell & gene therapies with batch sizes at low volumes. With its high filling accuracy, the platform provides filling for up to 36 bags with one rack - having the option to attach more racks.

RoSS.KSET top view

ROSS.KSET | Protecting small single-use bags

RoSS.KSET offers the protection for drug substances with volumes less than 250 mL. The shell of our CGT bag protection system is robust, closed, safe and sterile – most suitable for cell and gene therapies or clinical studies.

For larger volumes, RoSS can protect one or multiple single-use bags in one shell.

Lab freezer pharma with RoSS.pFTU labscale

RoSS.pFTU Lab-Scale

Compatible with single use bags of all sizes and manufacturers. Our lab scale freezer is the perfect solution for studies conducted in labs and, above all, if you want to start a controlled and scalable freezing process.

ross-padl-scaled

RoSS.PADL | Homogenizing Solution

RoSS.PADL is a scalable platform for cooling your single-use bag whilst gently massaging it to ensure there is a homogenous mixture of the solution. With the RoSS.PADL multiple cooling and massaging mechanisms can be placed side by side with one control system.

FAQ about cryogenic freezing

What is a cryogenic freezer?

A cryogenic freezer is a device that is made to freeze goods like certain biological down to extremely low – cryogenic – temperatures. Often, liquid nitrogen is used to achieve temperatures lower than -150°C and to cryogenically freeze goods.

What is cryogenic freezing?

Cryogenic freezing is a procedure where goods like certain biologicals are cooled down to extremely low temperatures, usually between -150°C and -180°C. Depending on specific product requirements, cryogenic temperatures are used to preserve goods over time and stop processes like cell metabolism that would affect their quality.

What is cryopreservation?

Cryopreservation is a process carried out along the supply chain of certain biologicals in order to maintain their structure and capabilities over time. By the means of cryogenic temperatures, cell metabolism and other processes within a product (like cells, genomic materials, tissue or organs) that would promote its deterioration are slowed/stopped so that it can be stored over time with little to no quality loss.

Cryopreservation requires extremely cold temperatures, lower than -180°C.

How does a cryogenic freezer work?

In contrast to household chest freezers, a cryogenic freezer is a device that achieves extremely low – cryogenic – temperatures to cool various types of products, such as biological.

Cryogenic freezers often use liquid nitrogen to be injected into a cooling chamber, whereby it is necessary to avoid contamination of the product to be frozen with LN2.

How much does a cryogenic freezer cost?

Although the price range for cryogenic freezers is wide, one can state that they are usually more expensive than regular freezers (that cannot achieve these low temperatures), given the fact that cryopreservation is a highly complex procedure. Therefore, several safety mechanisms need to be in place, as well as measures that must be taken to avoid contamination.

Where else can cryogenic freezing be encountered?

Besides the development and storage of biologics and organic materials in the biopharma industry, cryogenic freezing is known to many people as a way of “cheating death” or literally a life insurance for VIPs from science fiction movies: Bodies are brought to cryonics institutes or cryonics facilities; then the whole bodies are cryogenically frozen by cryonicists.

In cryonic preservation, it is hoped that medical technology will make such progress that the frozen bodies will one day be able to leave the cryonics process and, after thawing, be brought back to life (arising like a phoenix), with an intact human body and living tissue rather than as a human corpse respectively dead bodies. Hereby, it is necessary to avoid damage caused by the formation of ice crystals, choosing e.g. vitrification as a freezing method or the proper cryoprotectant, working as an antifreeze.

One large field of application for the cryogenic freezing process is food processing; by deep freezing food products with refrigerants such as liquified carbon dioxide or dry ice, they are prepared for storage and transportation.

More information

Whitepaper_Controlled_Scalable_Freezing_SEP22

Whitepaper: How controlled freezing enables scalability

In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.

cryopreservation-process

Cryopreservation: What you need to know about cryogenic freezing

Cryopreservation is an effective procedure for the quality-preserving storage of many biomaterials. Find out what cryopreservation actually is, what has to be considered along the process and where it is applied – all summed up in this article.

RoSS.pFTU Lab Scale - in process (1 von 9)-min

App Note: Cell Monolayer Cryopreservation

Advanced cell-based assay workflow with CryoLogyx Thaw and Test pre-plated cell and controlled, scalable freezing process solution RoSS.pFTU to achieve effective cryopreservation of cells.

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