MESSENGER RNA (MRNA)

Close-up of small single-use bags during aseptic filling.

mRNA Manufacturing Solutions

Temperature plays a key role in the Messenger RNA (mRNA) supply chain, as single doses biotherapeutics or vaccines must be kept at temperatures similar to those used in their clinical trials: -70°C. To make the cold chain, which is often not designed for such low temperatures, continuous, it is necessary to optimize processes to protect drugs and biologics from temperature fluctuations.

mRNA Process Overview

From Production & Purification to Formulation & Filling, there are several process steps that are involved in the manufacturing process of mRNA. These include aliquotation & filtration, freeze & thaw, ultra cold storage and shipment.

The Chilled Future of RNA Therapeutics Filling & Freezing Applications

The fluid management process for mRNA,LNPs, pDNA and viral vectors for cryopreservation are often performed manually and in an uncontrolled manner. As a result, they are prone to inefficiencies and increased product loss. Learn how modular and flexible single-use technologies optimize the manufacturing process in the App Note.

Preview of an app note about filling and freezing of RNA therapeutics

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App Note: The Chilled Future of RNA Therapeutics Filling & Freezing Applications

This application note explores scalable, GMP-compatible solutions for the sterile filling and cryopreservation of mRNA, pDNA, and viral vectors. It presents modular technologies that ensure temperature control, minimize product loss, and support high-accuracy aliquotation - paving the way for efficient commercialization of RNA-based therapeutics.

App Note: The Chilled Future of RNA Therapeutics Filling & Freezing Applications
 

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