MONOCLONAL ANTIBODIES (MABS)

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Safe Handling and Freezing/Thawing of Monoclonal Antibodies (mAbs)

Controlled processes play a vital role for monoclonal antibodies (mAbs) manufacturing processes. mAbs require special care and sensitive handling at every step of development and production, as well as in logistics, so as not to compromise their effectiveness. Additionally, controlled andfast freezing and thawing ratescan add to improved levels of quality and lead to better overall results.

Guide for mAb manufacturing - 5 Most Overlooked Challenges

Guide for monoclonal antibody manufacturing with regards to fluid and cold chain management - 5 Most Overlooked Challenges. In detail:

  • Efficiency in CHO cell expansion process
  • Scalability in fluid management
  • Protein aggregation during mAb freezing & thawing
  • Contamination risks
  • Efficiency in mAb production
Preview of Single Use Support's guide about monoclonal antibody manufacturing

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Guide: Challenges in mAb Manufacturing

Guide how to navigate challenges in monoclonal antibody production with regards to fluid and cold chain management challenges, such as efficiency in CHO cell expansion process, scalability, protein aggregation during mAb freezing & thawing.

Guide: Challenges in mAb Manufacturing
 

Single-Use Technologies in Monoclonal Antibodies Production

  • Single-use technologies are highly flexible and scalable; thus, they offer the ideal solution for processing antibodies, cells and genes in a variety of volumes. 

    The growing range of therapies and compounds calls for plants and systems that are or can be adapted to the increased speed of development and production as well as constantly changing requirements. In the case of monoclonal antibodies special focus should be put on viscosity: As a result of protein-protein interactions, concentrated mAb solutions can exhibit high levels of viscosity that may pose challenges during the manufacturing process.

  • Image of a controlled plate freezer loaded with RoSS shells.

The ROI of bulk freezing with plate freezers

The switch from cryovessels to plate-based freeze & thaw single-use technologies is, not least, a matter of costs. To determine the return on investment (ROI), different cost drivers were identified and evaluated. Discover the comparison of cryovessels, blast freezers and plate-based freezers in this case study.

Preview of Single Use Support's case study about the ROI of bulk freezing

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Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

An CDMO aspires to achieve improved freezing control, uniformity, and scalability when freezing BDS. New technologies are meant to reduce the need for manual handling as well as increase process efficiency and throughput. The goal was to evaluate and determine the return on investment (ROI) of cryovessels and plate freezers when freezing bulk.

Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers
 

More information

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