Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezers

Case Study RoSS.pFTU: The ROI of Bulk Freezing with Plate Freezer

In bioprocessing, the transfer of large volumes of liquids occurs frequently across various stages and it encompasses upstream processing, downstream processing, and intermediate steps. In intermediate process steps the bulk drug substance is cryopreserved. Large volumes of drug substances are frozen to ultra-cold temperatures for long-term storage, transport and distribution at approx. -80°C/-112°F.

An CDMO aspires to achieve improved freezing control, uniformity, and scalability when freezing BDS. New technologies are meant to reduce the need for manual handling as well as increase process efficiency and throughput. The goal was to evaluate and determine the return on investment (ROI) of cryovessels and plate freezers when freezing bulk.