Explore our extensive articles on bioprocessing, covering a wide range of topics to enhance your knowledge and practices. Read about different process steps in biomanufacturing: Upstream bioprocessing (USP) includes cell line development, cell banking, fermentation and more. Downstream bioprocessing (DSP) includes purification, formulation and chromotography and final filling and filtration into single-use bags for shipment to fill/finish. Stay informed and make better decisions with our expert analysis and comprehensive guides on single-use technologies and consumables.
Bioprocessing
Khalil Essani, Product Line Manager at Single Use Support, is an expert in bioprocessing applications for single-use technologies. He provides valuable insights in the use of cell banking in seed train intensification.
Khalil Essani
April 4, 2024
Bioprocessing
PUPSIT will contribute to simplifying not only integrity testing and validation but manufacturing processes in general, while keeping in line with current good manufacturing processes and any standards and guidelines defined by major authorities such as FDA and EMA. Read all about it!
David Seifert
March 7, 2022
Bioprocessing
Upstream intensification processes use high density cell banking to optimize monoclonal antibody production. How does HDCB advance cell expansion? And is seed train intensification relevant to biosimilars?
Brian Moloney
February 12, 2025
Bioprocessing
Seed train intensification is an upstream bioprocessing strategy to improve productivty through modern technologies applying High Cell Density Cryopreservation (HCDC). Learn how seed train intensification can help manufacturers advance production of proteins, such as antibody drug products.
Khalil Essani
November 28, 2024
Bioprocessing
There are several parameters to be considered in the attempt to maximize efficiency in biomanufacturing. In this article, we will discuss different areas that have an impact on process efficiency, including ways to improve them.
Michael Mühlegger
May 13, 2024
Bioprocessing
Khalil Essani, Product Line Manager at Single Use Support, is an expert in bioprocessing applications for single-use technologies. He provides valuable insights in the use of cell banking in seed train intensification.
Khalil Essani
April 4, 2024
Bioprocessing
Biopharmaceutical processing is indispensable across various fields of medicine and life sciences. In this article, we will discover how single-use solutions can increase efficiency and safety in biopharmaceutical processing.
Khalil Essani
November 6, 2023
Bioprocessing
As the market is constantly evolving, new, fully automated solutions are offered to make GMP cell banking and cGMP cell banking easier to achieve. Single Use Support’s solutions do not only reach out to help make the handling of cell banks safer and more efficient, but also help to support smaller-scale projects through scalable solutions.
Brian Moloney
August 9, 2023
Bioprocessing
Cell thawing is a critical procedure in the area of life science and medicine. Ensuring a gentle thawing of frozen cells is essential for preserving their viability and functionality. In this article, we will highlight the cell thawing process, discuss common challenges, and provide recommendations for achieving optimal results in cell banking.
Brian Moloney
August 9, 2023
Bioprocessing
Who can relate to the situation when every cell aliquot is different? That's why cell homogenization and aliquotation are important requirements in modern cell biology research, relevant for scientists and laboratory staff. Scientists and process engineers benefit from uniform cell distribution throughout multiple single-use bioprocess containers for cell banking or other bioprocessing steps.
Brian Moloney
August 9, 2023
Bioprocessing
In cell banking, one can distinguish four different types of cell banks, all of which are involved in the manufacturing of cell-based products. In this article, we will discuss them all.
Michael Eder
August 3, 2023
Bioprocessing
Cell banks are fundamental in the production of several biopharmaceutical products, their manufacturing a highly complex process. In this article, we will explain cell bank manufacturing in detail, including the challenges it is related to.
Brian Moloney
August 3, 2023
Bioprocessing
Both master and working cell banks belong to the four general types of cell banks. Although having much in common, there are some major differences between MCBs and WCBs, which we will uncover in this article.
Michael Eder
August 2, 2023
Bioprocessing
Cryopreservation is a necessary procedure to maintain cell viability during ex vivo storage. In this article, we will provide some general information on cell cryopreservation, but also discuss different tools, challenges and an exemplary protocol.
Brian Moloney
August 2, 2023
Articles by Biopharmaceutical Products:
Articles by Manufacturing Processes:
E-Book
Cell Banking in Seed Train Intensification is a crucial process step in upstream bioprocessing for biopharmaceutical production. Cells that can be cultured into large aliquots, e.g. with cell suspensions, can greatly optimize the cell culture intensification process.
E-Book
Guide about Handling Liquids in Biopharmaceutical Fermentation | Scalability in Microbial Mammalian Fungal Fermentation | Replacing Spray Drying and Lyophilization with Bulk Plate Freezing | Speed of Handling Large Volumes in Fermentation | Bag Breakages in fermentation cold chain logistics
E-Book
Throughout the entire manufacturing process, pharmaceutical liquids are transferred and have touchpoints within upstream bioprocessing, downstream bioprocessing and fill/finish. Single Use Support provides single-use assemblies and with it capabilities in Dual Sourcing, Customization and Qualification. | Strengthening the Supply Chain | Development of off-the-shelf assemblies | GMP-compliant solutions
