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mRNA & LNPs

mRNA technology simply explained

New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce specific proteins. Nevertheless, the heightened demand for mRNA drugs leads to challenges for its production.

Daniel Tischler

June 15, 2023

mRNA & LNPs

Non-viral vectors in gene therapy: LNPs in the spotlight

Non-viral vectors play an increasingly important role in biomedical research and therapy, including gene therapy. In this article, we will discuss the role of non-viral vectors for this specific purpose.

Michael Mühlegger

June 13, 2023

IRIS Single-Use Assmeblies_Production Kufstein-9

Single-use Consumables

Navigating GMP Annex 1: How Single-Use Assemblies will Comply

GMP Annex 1 significantly impacts the use of single-use assemblies in fluid management processes within the biopharmaceutical industry. It requires manufacturers and stakeholders to adopt a risk-based approach, implement proper controls, and ensure the integrity and sterility of single-use systems.

David Seifert

June 13, 2023

mRNA & LNPs

Where are lipid nanoparticles (LNPs) used?

Lipid nanoparticles are multifunctional tools used in a variety of different applications, supporting mRNA as a valuable instrument in medicine and research. In this article, we will shed light on what the different applications of LNPs are.

Daniel Tischler

June 6, 2023

Safe shipping of pharmaceutical liquids with single-use systems

Bioconjugates

Transport & Storage of Antibody Drug Conjugates (ADCs)

ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and the potency of the cytotoxic drug. This is why safe handling in between facilities is such an important issue and must not be taken lightly.

Brian Moloney

May 9, 2023

Bioconjugates

Bioconjugates: Examples & Applications

Bioconjugates are powerful tools in several areas of life sciences and beyond. In this article, we will have a look at the technology in general as well as at examples of bioconjugates in specific fields.

Michael Eder

April 26, 2023

Bioconjugates

Examples of Antibody-drug conjugates

Depending on their constituents, ADCs are extremely variable and can be used for several, very distinct purposes. In this article, we will present you 5 examples of ADCs and their respective characteristics.

Brian Moloney

April 25, 2023

Bioconjugates

ADC technology simply explained

ADC technology has revolutionized several fields in medicine and research. In this article, we will shed light on this groundbreaking technology.

Daniel Tischler

April 25, 2023

Bioconjugates

7 Must-Known Facts About Antibody-Drug Conjugates (ADCs)

Antibody drug conjugates (ADCs) are a rapidly growing field of interest in biopharmaceutics. In comparison to conventional chemotherapy treatments, ADCs have the potential to destroy cancerous cells without damaging healthy cells in the process. In this article we will give you an introduction to this important and rapidly growing field.

Brian Moloney

April 24, 2023

Sterile bag filling - Single-use handling in biopharma on another level

Bioconjugates

Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure sterility and rule out any potential cross-contamination as well as potential harm to handling staff.

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugates manufacturing & the advances with single-use technology

The manufacturing of bioconjugates is a complex process that involves linking a drug payload with a targeting moiety using a linker. The process is highly specific and requires careful optimization to ensure that the bioconjugate is effective and safe for use in patients. Single-use technology has revolutionized the manufacturing of bioconjugates by offering a range of benefits over traditional stainless-steel manufacturing. Therefore, this article will pay special attention to this subject.

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugation simply explained

Bioconjugation is a pharmaceutical technique that is gaining more and more importance, most of all in cancer therapy. In this article, we will provide some basic information on bioconjugation, but also discuss major challenges related to this field.

Michael Mühlegger

April 20, 2023

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

Whitepaper_Controlled_Scalable_Freezing_SEP22

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

1021-Whitepaper_RoSS.FILL_Automated Aseptic Filling_Single Use Support

E-Book

Whitepaper: Automated Aseptic Filling

Automated Aseptic Filling Unprecedented flexibility to filling well