All articles

mRNA & LNPs

Freezing LNPs & the impact on their long-term stability

Freezing is a significant process step in the manufacturing of LNP-based products. In this article, we will therefore take a look at the impact freezing has on lipid nanoparticles.

Alexander Fuchs | Single Use Support

Alexander Fuchs

June 26, 2023

Freeze & Thaw

Evolving Methods of Bulk Freezing

New technologies, sauch as plate-based freezing and thawing based on single-use systems, improve process efficiency and product quality. Innovative solutions are breaking the ice for the evolution of bulk drug freezing.

micheal-eder

Michael Eder

June 23, 2023

mRNA & LNPs

Lipid nanoparticle (LNP) manufacturing: Challenges & Solutions

Being promising tools in life sciences and medicine, lipid nanoparticles are drawing attention on their manifold advantages. In this article, however, we take a step back and discover how LNPs are produced. Solutions based on single-use systems for increasing quality and efficiency in production are also covered. 

BRMO

Brian Moloney

June 21, 2023

mRNA & LNPs

Lipid nanoparticles toxicity: What to consider?

Lipid nanoparticles (LNPs) have shown to bring several benefits to research and therapy. This article, however, focuses on concerns on LNP toxicity and ways o address them.

daniel-tischler

Daniel Tischler

June 19, 2023

mRNA & LNPs

Pros & Cons of lipid nanoparticles for mRNA delivery

Lipid nanoparticles are highly valued tools in the field of mRNA delivery, making them essential for various therapeutic and research approaches. In this article, we will take a look at the pros and cons of LNPs in mRNA delivery.

michael-muehlegger

Michael Mühlegger

June 17, 2023

mRNA & LNPs

mRNA technology simply explained

New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce specific proteins. Nevertheless, the heightened demand for mRNA drugs leads to challenges for its production.

daniel-tischler

Daniel Tischler

June 15, 2023

mRNA & LNPs

Non-viral vectors in gene therapy: LNPs in the spotlight

Non-viral vectors play an increasingly important role in biomedical research and therapy, including gene therapy. In this article, we will discuss the role of non-viral vectors for this specific purpose.

michael-muehlegger

Michael Mühlegger

June 13, 2023

Single-use Consumables

Navigating GMP Annex 1: How Single-Use Assemblies will Comply

GMP Annex 1 significantly impacts the use of single-use assemblies in fluid management processes within the biopharmaceutical industry. It requires manufacturers and stakeholders to adopt a risk-based approach, implement proper controls, and ensure the integrity and sterility of single-use systems.

1640281789974

David Seifert

June 13, 2023

mRNA & LNPs

Where are lipid nanoparticles (LNPs) used?

Lipid nanoparticles are multifunctional tools used in a variety of different applications, supporting mRNA as a valuable instrument in medicine and research. In this article, we will shed light on what the different applications of LNPs are.

daniel-tischler

Daniel Tischler

June 6, 2023

Bioconjugates

Transport & Storage of Antibody Drug Conjugates (ADCs)

ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and the potency of the cytotoxic drug. This is why safe handling in between facilities is such an important issue and must not be taken lightly.

BRMO

Brian Moloney

May 9, 2023

Bioconjugates

Bioconjugates: Examples & Applications

Bioconjugates are powerful tools in several areas of life sciences and beyond. In this article, we will have a look at the technology in general as well as at examples of bioconjugates in specific fields.

micheal-eder

Michael Eder

April 26, 2023

Bioconjugates

Examples of Antibody-drug conjugates

Depending on their constituents, ADCs are extremely variable and can be used for several, very distinct purposes. In this article, we will present you 5 examples of ADCs and their respective characteristics.

BRMO

Brian Moloney

April 25, 2023

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Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

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