Knowledge

The advanced platforms of the newest generation of single use bags are generally compatible with a variety of bag brands and volumes. One of these platforms is Single Use Support’s RoSS®, which offers the benefit of not only being bag agnostic but also highly flexible thanks to its modular design. Learn more about the biggest player in the industry!

In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability. 

In this article we take a closer look at the top five companies in terms of annual revenue in the U.S., that dominate the field of antibody research, development and production. Further, we dive in the field of promising pioneers with a focus on mAb production for the use of cancer treatments. 

The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).

Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.

Monoclonal antibody development and manufacturing are highly specialized processes, demanding equally specialized equipment. We will discuss some essential tools and systems in this article.

Monoclonal antibodies bring along some special requirements in terms of safe handling. In this article, we will discover what these requirements are, and how they can be met.

From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production. 

In the quest for efficient monoclonal antibody manufacturing, it's imperative to shed light on costs that are frequently underestimated. These costs can stem from various sources, including process development, high prices associated with biotherapeutics, and the evolving landscape of production technologies.

mAb production requires high levels of expertise and precision, as well as specialized equipment. Nonetheless, there are several challenges that manufacturers have to deal with.

In many cases, antibodies need to be stored for varying time spans before further processing or administration. Hence, it is essential to mind the characteristic storage requirements of these valuable biologics.

Filling monoclonal antibodies requires dedicated solutions that allow smooth and safe mAb processing. In this article, we will discuss some of the integral components in this procedure.