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RNase Contamination Challenges - Single Use Support

Nucleic Acids

RNase Contamination – Challenges & Solutions

This article explores the challenges posed by RNase contamination and the solutions that can be employed to mitigate these risks. RNase contamination | Ribonuclease inhibitors | RNase-free equipment

David Seifert

August 13, 2024

Single Use Support RNase Contamination RNA

Nucleic Acids

RNase: Ribonuclease Simply Explained

RNase contamination can lead to the degradation of RNA, thereby compromising the efficacy of RNA-based drugs. Types of RNase | RNase and DNase | Role of DEPC

David Seifert

August 12, 2024

Single-use Technology

Blocking UV Light from Biopharmaceuticals

New on the market are single-use bags that are designed to block ultraviolet (UV) light. By utilizing cold chain packagings that effectively block UV light, manufacturers can maintain the integrity and quality of their products throughout the entire bioprocessing chain.

David Seifert

July 26, 2024

Cell & Gene Therapy

The Role of Single-Use Systems in Cell and Gene Therapies

Ensuring that cell and gene therapy products are shipped at cold temperatures with robust controls is even more important for cell & gene therapies than it is for more traditional biopharmaceutical products.

Michael Mühlegger

July 8, 2024

Vaccines

Fluid management solutions for biosimilar production

In biosimilar production, fluid management takes on an overarching role, as it is encountered at several manufacturing steps. This is all the more reason to deal with efficiency in fluid management – which we will do in this article.

Brian Moloney

May 14, 2024

Vaccines

Challenges in manufacturing biosimilars

The manufacturing process of biosimilars is a complex endeavor, accompanied by several challenges. We will discuss some of the biggest hurdles in this article, along with solutions to overcome them.

Brian Moloney

May 14, 2024

Optimizing pDNA production using advanced single-use technologies

Bioprocessing

How to optimize biomanufacturing efficiency

There are several parameters to be considered in the attempt to maximize efficiency in biomanufacturing. In this article, we will discuss different areas that have an impact on process efficiency, including ways to improve them.

Michael Mühlegger

May 13, 2024

Vaccines

The development process of biosimilars

The development process of biosimilars slightly differs from the one of their reference biologics. In this article, we will discuss each phase in detail.

Michael Eder

May 13, 2024

RoSS.FILL - single use filling machine for CGT bags

Vaccines

Biomanufacturing: Process, steps and challenges in manufacturing biologics

As biologics have become a central pillar in today’s healthcare sector, their manufacturing process increasingly draws attention. In this article, we will discuss the process step by step, including challenges and possible ways to overcome them.

Michael Eder

May 13, 2024

Efficient strategies for the safe manufacturing of biosimilars

Vaccines

Efficient strategies for manufacturing biosimilars

Establishing both efficient and safe manufacturing processes for biosimilars requires planning, expertise, and state-of-the-art equipment. In this article, we will shed light on different steps in the manufacturing process and discuss ways to improve them.

Michael Eder

May 8, 2024

Freezing and thawing in biosimilar production

Vaccines

Freeze thaw processes in biosimilar production

Freezing and thawing are essential steps in the cold chain management of biosimilars. With several methods eligible, we have chosen some prominent ones, explaining their advantages, limitations, and our preferred choices.

Alexander Fuchs

May 8, 2024

Vaccines

Overview of FDA approved biosimilars

Over the years, several biosimilars have been approved as alternatives for often more costly biologics. We have listed them, along with the product they refer to.

Michael Mühlegger

May 8, 2024

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

Single-Use-Support-Controlled-Freezing-Biopharmaceuticals

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

aav-production-efficiency-improvements-single-use-technology

E-Book

Whitepaper: Automated Aseptic Filling

Read our Whitepaper about Automated Aseptic Filling in Pharmaceutical Manufacturing | Discover why automatic filling solutions are preferable to manual filling.