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Viral Vectors

Freezing & thawing viral vectors: Best practices

Proper handling of viral vectors during storage, freezing, and thawing is crucial to maintaining their integrity and efficacy. In this article, we will explore best practices for preserving viral vectors, ensuring their stability, and maximizing their potential for various applications.

Alexander Fuchs | Single Use Support

Alexander Fuchs

September 20, 2023

Viral Vectors

Safe storage & handling of viral vectors

Viral vectors like Adeno-associated viruses (AAVs) are popular vectors for gene therapy and vaccines. And yet, there is product loss due to leakages of primary packagings or other mishandling of fluids. In order to deliver high-quality and viable products efficiently, safe handling experience a growing interest.

Claus Exenberger - Single Use Support

Claus Exenberger

September 20, 2023

Viral Vectors

3 Examples of FDA approved AAVs in gene therapy

In this blog post, we'll show examples of AAVs as gene therapy vectors and examine the tangible results of FDA-approved AAV gene therapies, which offer actual solutions and hope for patients affected by genetic disorders. 

michael-muehlegger

Michael Mühlegger

September 19, 2023

Viral Vectors

What is the difference between adeno-associated virus and adenovirus?

The main difference between adeno-associated viral vectors (AAV) and adenoviral vectors (AVV) is their genetic makeup. AAV is composed of a single-stranded DNA viral vector, while adenoviral vectors consist of double-stranded DNA.

michael-muehlegger

Michael Mühlegger

September 19, 2023

Viral Vectors

Types of viral vectors

Various types of viral vectors are central to genetic research and medical advancements. These small carriers, obtained from various viruses, play an essential role in gene therapy and beyond. In this exploration, we will examine different types, the applications, unique attributes, and the complex terrain of producing viral vectors.

michael-muehlegger

Michael Mühlegger

September 19, 2023

Viral Vectors

Adeno-Associated Virus (AAV) for gene therapy

The adeno-associated virus (AAV) is a very popular viral vector with great potential available for gene delivery. This article explores AAV vectors, their role in gene therapy, and their associated advantages and disadvantages.

Khalil Essani - Single Use Support

Khalil Essani

September 18, 2023

Cell & Gene Therapy

Plasmid DNA manufacturing companies – market overview

In this article, we will give an overview of the pDNA manufacturing market – not only taking a look at the dry figures, but also highlighting the services that are offered by important plasmid DNA manufacturing companies.

daniel-tischler

Daniel Tischler

September 13, 2023

Cell & Gene Therapy

What is the function of plasmid DNA?

Plasmid DNA fulfills several functions in bacteria, but they are also widely used in the biopharma sector. In this article, we will uncover their key functions.

michael-muehlegger

Michael Mühlegger

September 13, 2023

Cell & Gene Therapy

Plasmid DNA manufacturing: The process simply explained

The pDNA manufacturing process is multifaceted yet essential in the biopharmaceutical industry. Here, we will describe the process step by step.

michael-muehlegger

Michael Mühlegger

September 12, 2023

Cell & Gene Therapy

What is a plasmid?

Plasmids are part of the genetic material in bacteria, complementing chromosomal DNA with additional functions. But there is much more to plasmids, as you can read in this article.

michael-muehlegger

Michael Mühlegger

September 7, 2023

Cell & Gene Therapy

Plasmid DNA – 7 facts about pDNA

Plasmid DNA is not only found in bacteria, but also ubiquitous in biotechnology. In this article, we have collected 7 interesting facts on pDNA.

michael-muehlegger

Michael Mühlegger

September 7, 2023

Freeze & Thaw

Sustainable Freezing in Biopharma: An Exploration of Natural Gas Usage

In the biopharmaceutical sector, the utilization of F-Gases is on a decline. However, the need for cryopreservation of drug substances will remain. In order to contribute to a more environmentally friendly freezing of drugs, more sustainable technologies need to be developed and applied. But is sustainable freezing even possible?

Alexander Fuchs | Single Use Support

Alexander Fuchs

September 6, 2023

Recommended Downloads

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eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

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Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

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Automated Aseptic Filling Unprecedented flexibility to filling well