Knowledge

May 9, 2023

Transport & Storage of Antibody Drug Conjugates (ADCs)

BRMO
Brian Moloney

ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and the potency of the cytotoxic drug. This is why safe handling in between facilities is such an important issue and must not be taken lightly.

May 8, 2023

FDA approved ADCs for cancer therapy

michael-muehlegger
Michael Mühlegger

ADCs offer new, highly promising approaches in the therapy of various cancer types, and the number of approved ADCs is continuously growing. In this article, we will have a look at ADCs currently approved.

April 26, 2023

Bioconjugates: Examples & Applications

micheal-eder
Michael Eder

Bioconjugates are powerful tools in several areas of life sciences and beyond. In this article, we will have a look at the technology in general as well as at examples of bioconjugates in specific fields.

April 25, 2023

Examples of Antibody-drug conjugates

BRMO
Brian Moloney

Depending on their constituents, ADCs are extremely variable and can be used for several, very distinct purposes. In this article, we will present you 5 examples of ADCs and their respective characteristics.

April 25, 2023

ADC technology simply explained

bernhard-schlichtner
Bernhard Schlichtner

ADC technology has revolutionized several fields in medicine and research. In this article, we will shed light on this groundbreaking technology.

April 24, 2023

Antibody drug conjugates: 7 facts about ADCs

BRMO
Brian Moloney

Antibody drug conjugates (ADCs) are a rapidly growing field of interest in biopharmaceutics. In comparison to conventional chemotherapy treatments, ADCs have the potential to destroy cancerous cells without damaging healthy cells in the process. In this article we will give you an introduction to this important and rapidly growing field. 

April 24, 2023

Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

BRMO
Brian Moloney

The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure sterility and rule out any potential cross-contamination as well as potential harm to handling staff.

April 24, 2023

Bioconjugates manufacturing & the advances with single-use technology

BRMO
Brian Moloney

The manufacturing of bioconjugates is a complex process that involves linking a drug payload with a targeting moiety using a linker. The process is highly specific and requires careful optimization to ensure that the bioconjugate is effective and safe for use in patients. Single-use technology has revolutionized the manufacturing of bioconjugates by offering a range of benefits over traditional stainless-steel manufacturing. Therefore, this article will pay special attention to this subject. 

April 21, 2023

ADC manufacturing & the challenges to overcome

BRMO
Brian Moloney

Scale-up and industrial production of ADCs face complications due to the high safety measures which need to be taken to guarantee product efficacy and a protected working environment for staff and manufacturers. In this article we seek out to give you an overview of the different challenges during ADC manufacturing while also introducing solutions which help to ensure aseptic production methods through single-use-technologies and end-to-end systems. 

April 20, 2023

Bioconjugation simply explained

michael-muehlegger
Michael Mühlegger

Bioconjugation is a pharmaceutical technique that is gaining more and more importance, most of all in cancer therapy. In this article, we will provide some basic information on bioconjugation, but also discuss major challenges related to this field.
 

April 20, 2023

What is autologous?

micheal-eder
Michael Eder

The term "autologous" is most frequently found in the context of cell therapy. In this article, we will therefore take a closer look at this revolutionary therapeutic approach.

April 19, 2023

What is allogeneic?

micheal-eder
Michael Eder

What does "allogeneic" mean, precisely? How do allogeneic cell therapies work, and what is the difference to autologous approaches? Questions like these will be answered in this article.