Knowledge

June 26, 2023

Freezing LNPs & the impact on their long-term stability

Alexander Fuchs | Single Use Support
Alexander Fuchs

Freezing is a significant process step in the manufacturing of LNP-based products. In this article, we will therefore take a look at the impact freezing has on lipid nanoparticles.

June 23, 2023

Evolving Methods of Bulk Freezing

micheal-eder
Michael Eder

New technologies, sauch as plate-based freezing and thawing based on single-use systems, improve process efficiency and product quality. Innovative solutions are breaking the ice for the evolution of bulk drug freezing.

June 21, 2023

Lipid nanoparticle (LNP) manufacturing: Challenges & Solutions

BRMO
Brian Moloney

Being promising tools in life sciences and medicine, lipid nanoparticles are drawing attention on their manifold advantages. In this article, however, we take a step back and discover how LNPs are produced. Solutions based on single-use systems for increasing quality and efficiency in production are also covered. 

June 19, 2023

Lipid nanoparticles toxicity: What to consider?

daniel-tischler
Daniel Tischler

Lipid nanoparticles (LNPs) have shown to bring several benefits to research and therapy. This article, however, focuses on concerns on LNP toxicity and ways o address them.

June 17, 2023

Pros & Cons of lipid nanoparticles for mRNA delivery

michael-muehlegger
Michael Mühlegger

Lipid nanoparticles are highly valued tools in the field of mRNA delivery, making them essential for various therapeutic and research approaches. In this article, we will take a look at the pros and cons of LNPs in mRNA delivery.

June 15, 2023

mRNA technology simply explained

daniel-tischler
Daniel Tischler

New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce specific proteins. Nevertheless, the heightened demand for mRNA drugs leads to challenges for its production.

June 13, 2023

Non-viral vectors in gene therapy: LNPs in the spotlight

michael-muehlegger
Michael Mühlegger

Non-viral vectors play an increasingly important role in biomedical research and therapy, including gene therapy. In this article, we will discuss the role of non-viral vectors for this specific purpose.

June 13, 2023

Navigating GMP Annex 1: How Single-Use Assemblies will Comply

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David Seifert

GMP Annex 1 significantly impacts the use of single-use assemblies in fluid management processes within the biopharmaceutical industry. It requires manufacturers and stakeholders to adopt a risk-based approach, implement proper controls, and ensure the integrity and sterility of single-use systems.

June 6, 2023

Where are lipid nanoparticles (LNPs) used?

daniel-tischler
Daniel Tischler

Lipid nanoparticles are multifunctional tools used in a variety of different applications, supporting mRNA as a valuable instrument in medicine and research. In this article, we will shed light on what the different applications of LNPs are.

May 9, 2023

Transport & Storage of Antibody Drug Conjugates (ADCs)

BRMO
Brian Moloney

ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and the potency of the cytotoxic drug. This is why safe handling in between facilities is such an important issue and must not be taken lightly.

May 8, 2023

FDA approved ADCs for cancer therapy

michael-muehlegger
Michael Mühlegger

ADCs offer new, highly promising approaches in the therapy of various cancer types, and the number of approved ADCs is continuously growing. In this article, we will have a look at ADCs currently approved.

April 26, 2023

Bioconjugates: Examples & Applications

micheal-eder
Michael Eder

Bioconjugates are powerful tools in several areas of life sciences and beyond. In this article, we will have a look at the technology in general as well as at examples of bioconjugates in specific fields.