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Bioprocessing

Homogenization of cells & aliquotation in single-use bags

Who can relate to the situation when every cell aliquot is different? That's why cell homogenization and aliquotation are important requirements in modern cell biology research, relevant for scientists and laboratory staff. Scientists and process engineers benefit from uniform cell distribution throughout multiple single-use bioprocess containers for cell banking or other bioprocessing steps.

Brian Moloney

August 9, 2023

Bioprocessing

Types of cell banks: An overview

In cell banking, one can distinguish four different types of cell banks, all of which are involved in the manufacturing of cell-based products. In this article, we will discuss them all.

Michael Eder

August 3, 2023

Bioprocessing

Cell bank manufacturing: From master to working cell bank

Cell banks are fundamental in the production of several biopharmaceutical products, their manufacturing a highly complex process. In this article, we will explain cell bank manufacturing in detail, including the challenges it is related to.

Brian Moloney

August 3, 2023

Bioprocessing

The differences between master cell bank (MCB) and working cell bank (WCB)

Both master and working cell banks belong to the four general types of cell banks. Although having much in common, there are some major differences between MCBs and WCBs, which we will uncover in this article.

Michael Eder

August 2, 2023

Bioprocessing

Cryopreservation of cells: Preserving cells for future use

Cryopreservation is a necessary procedure to maintain cell viability during ex vivo storage. In this article, we will provide some general information on cell cryopreservation, but also discuss different tools, challenges and an exemplary protocol.

Brian Moloney

August 2, 2023

Bioprocessing

How to maintain a cell bank?

Proper storage of cells and maintenance of a cell bank is essential to uphold the integrity and reproducibility of experimental results. In this article, we will show best practices for maintaining a cell bank, from initial cell line characterization to cGMP compliance, storage, and troubleshooting tips.

Michael Eder

August 1, 2023

RoSS.KSET freezing single-use bags Cell Banking

Bioprocessing

Advantages of cell banking

By preserving and storing valuable cell lines, cell banking ensures a stable and consistent source of cells for various applications. In this blog post, we will explore the numerous advantages of cell banking and its pivotal role in driving advancements in the fields of science and medicine.

Michael Eder

August 1, 2023

Bioprocessing

The purpose of cell banking: Uses & Applications

At the core of cutting-edge research and biopharmaceutical production lies the crucial need to preserve and store precious cell lines, ensuring their availability for future studies and therapeutic applications. In this article, we will explore the purpose and applications of cell banking, examining its significance in scientific discoveries and medical breakthroughs.

Michael Eder

August 1, 2023

Bioprocessing

Cell banking: Definition, Process & Manufacturing

Cell banking plays a key role in securing valuable cell lines and biological resources for future research and applications in the field of biotechnology. This article aims to provide a comprehensive overview of cell banking, its definition, importance, and the essential components involved in establishing and maintaining cell banks.

Michael Eder

August 1, 2023

Bioprocessing

Freezing cells – considerations and solutions

A fundamental process to preserve the ex vivo viability of cells is freezing them to extremely low temperatures. This is a complex and delicate task, requiring both expertise and professional equipment. In this article, we will take a look at the most important aspects of the cell freezing process.

Brian Moloney

August 1, 2023

Cell & Gene Therapy

How to measure and improve cell viability?

Cell viability is a fundamental parameter in cell-based biopharma processing and cell banking. Therefore, it is essential not only to measure cell viability, but also to take measures for its improvement. Learn more in this article.

Michael Eder

July 31, 2023

Freeze & Thaw

Cryovessels in Biopharmaceutical Manufacture: When Does the Tank Run Out?

It is many decades since cryovessels emerged as a groundbreaking solution in the biopharmaceutical industry, enabling the safe and efficient storage of bulk drug substances. However, the introduction of plate-based freezing methods has further advanced the technology available for the freezing of biopharmaceuticals, offering improved product quality and consistency.

Daniel Tischler

July 28, 2023

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

Single-Use-Support-Controlled-Freezing-Biopharmaceuticals

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

aav-production-efficiency-improvements-single-use-technology

E-Book

Whitepaper: Automated Aseptic Filling

Read our Whitepaper about Automated Aseptic Filling in Pharmaceutical Manufacturing | Discover why automatic filling solutions are preferable to manual filling.