All articles

Bioconjugates

History & Development of ADCs

Since the first ADCs entered clinical trials in the 1990s, they have shown great promise in treating a variety of cancers and other diseases. However, the development of ADCs has also been marked by challenges and setbacks, including issues with efficacy, safety, and manufacturing. In this article, we will explore the history of ADCs, from their early development to the latest advances in technology and applications.

micheal-eder

Michael Eder

April 14, 2023

Single-use Technology

Automated bioprocessing – 7 advantages of automation

Automation is affecting various aspects of our lives, including bioprocessing. In this article, we will explore the advantages that come with this development.

michael-muehlegger

Michael Mühlegger

April 12, 2023

Freeze & Thaw

Dry to Die: How Spray Drying can be Replaced by Freezing in the Production of Bulk Intermediates

Spray drying often leads to product losses of mAbs or vaccines of more than 30%. Plate-based freezing and thawing solutions enable controlled handling of bulk intermediates safely in a vendor-independent, modular and scalable fluid and cold chain management process. 

daniel-tischler

Daniel Tischler

April 12, 2023

Single-use Technology

Drug substance vs. drug product – these are the differences

The terms "drug substance" and "drug product" are often used synonymously, although there are some fundamental differences between them. We will point them out in the course of this article!

micheal-eder

Michael Eder

April 11, 2023

Single-use Technology

Bioprocessing – everything you need to know

Bioprocessing is a fundamental technology for various aspects of our lives, including the biopharma industry. In this article, we will provide some interesting facts about applications, techniques and future expectations regarding bioprocessing.

Khalil Essani - Single Use Support

Khalil Essani

April 6, 2023

End-to-end Solution

Biopharma supply chain – 7 risks to be aware of

The entire biopharma industry depends on intact supply chain in order to provide patients with the drug products they need. However, there are several factors that can put the integrity of supply chain at risk. In this article, we will discuss seven of them and explore what can be done to circumvent them.

michael-muehlegger

Michael Mühlegger

March 29, 2023

End-to-end Solution

Bulk drug substance management

The following article aims to take a closer look at the term “bulk drug substance” and its meaning, as well as to investigate smart solutions to shorten the phase between development and blockbuster production. Read more about the solution for the biopharmaceutical industry!

micheal-eder

Michael Eder

March 22, 2023

Fill & Filtration

Filling of drug substance: 5 threats you should know

When it comes to the filling process of drug substances, there several aspects to be considered to achieve high-quality results with as little product loss as possible. In this article, we will discuss 5 major threats for the filling of drug substances.

micheal-eder

Michael Eder

March 20, 2023

Fermentation

Microbial Fermentation Manufacturing: Advances through single-use technologies

Microbial fermentation is a powerful, flexible microbiology process used to generate microbial cells or biomass such as proteins and enzymes for the production of vaccines and therapeutics. There are still some challenges to overcome. Many of these challenges in fermentation manufacturing can be solved by replacing traditional systems with single-use technologies. 

daniel-tischler

Daniel Tischler

March 17, 2023

Single-use Technology

Biopharma packaging - requirements and solutions

In this article, we will discuss the special requirements of biologicals in terms of packaging as well as efficiency and sustainability aspects of biopharma packaging.

micheal-eder

Michael Eder

March 16, 2023

Fermentation

Challenges in microbial fermentation manufacturing

Microbial fermentation manufacturing is an effective method for the production of APIs, bioconjugates and smaller biologicals that play an important role in biotechnology and the production of biopharmaceuticals. Manufacturers face different challenges during microbial fermentation. Explore the 7 biggest challenges, followed by the introduction of new solutions.

daniel-tischler

Daniel Tischler

March 16, 2023

Fermentation

Filling & Freezing large volumes for fermentation in less than 8 hours

The filling and freezing of large volumes for fermentation is an essential part during different production steps in upstream and downstream processing.  In the following, we will explain why it is important to act fast and how an optimization of the process can be achieved. 

daniel-tischler

Daniel Tischler

March 16, 2023

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

Whitepaper: Automated Aseptic Filling

Automated Aseptic Filling Unprecedented flexibility to filling well