All articles

Bioconjugates

Examples of Antibody-drug conjugates

Depending on their constituents, ADCs are extremely variable and can be used for several, very distinct purposes. In this article, we will present you 5 examples of ADCs and their respective characteristics.

BRMO

Brian Moloney

April 25, 2023

Bioconjugates

ADC technology simply explained

ADC technology has revolutionized several fields in medicine and research. In this article, we will shed light on this groundbreaking technology.

daniel-tischler

Daniel Tischler

April 25, 2023

Bioconjugates

7 Must-Known Facts About Antibody-Drug Conjugates (ADCs)

Antibody drug conjugates (ADCs) are a rapidly growing field of interest in biopharmaceutics. In comparison to conventional chemotherapy treatments, ADCs have the potential to destroy cancerous cells without damaging healthy cells in the process. In this article we will give you an introduction to this important and rapidly growing field. 

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Safe Filling & Aliquoting of Antibody Drug Conjugates (ADCs)

The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure sterility and rule out any potential cross-contamination as well as potential harm to handling staff.

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugates manufacturing & the advances with single-use technology

The manufacturing of bioconjugates is a complex process that involves linking a drug payload with a targeting moiety using a linker. The process is highly specific and requires careful optimization to ensure that the bioconjugate is effective and safe for use in patients. Single-use technology has revolutionized the manufacturing of bioconjugates by offering a range of benefits over traditional stainless-steel manufacturing. Therefore, this article will pay special attention to this subject. 

BRMO

Brian Moloney

April 24, 2023

Bioconjugates

Bioconjugation simply explained

Bioconjugation is a pharmaceutical technique that is gaining more and more importance, most of all in cancer therapy. In this article, we will provide some basic information on bioconjugation, but also discuss major challenges related to this field.
 

michael-muehlegger

Michael Mühlegger

April 20, 2023

Cell & Gene Therapy

What is autologous?

The term "autologous" is most frequently found in the context of cell therapy. In this article, we will therefore take a closer look at this revolutionary therapeutic approach.

micheal-eder

Michael Eder

April 20, 2023

Cell & Gene Therapy

What is allogeneic?

What does "allogeneic" mean, precisely? How do allogeneic cell therapies work, and what is the difference to autologous approaches? Questions like these will be answered in this article.

micheal-eder

Michael Eder

April 19, 2023

Bioconjugates

History & Development of ADCs

Since the first ADCs entered clinical trials in the 1990s, they have shown great promise in treating a variety of cancers and other diseases. However, the development of ADCs has also been marked by challenges and setbacks, including issues with efficacy, safety, and manufacturing. In this article, we will explore the history of ADCs, from their early development to the latest advances in technology and applications.

micheal-eder

Michael Eder

April 14, 2023

Bioprocessing

Automated bioprocessing – 7 advantages of automation

Automation is affecting various aspects of our lives, including bioprocessing. In this article, we will explore the advantages that come with this development.

michael-muehlegger

Michael Mühlegger

April 12, 2023

Freeze & Thaw

Dry to Die: How Spray Drying can be Replaced by Freezing in the Production of Bulk Intermediates

Spray drying often leads to product losses of mAbs or vaccines of more than 30%. Plate-based freezing and thawing solutions enable controlled handling of bulk intermediates safely in a vendor-independent, modular and scalable fluid and cold chain management process. 

daniel-tischler

Daniel Tischler

April 12, 2023

Vaccines

Drug substance vs. drug product – these are the differences

The terms "drug substance" and "drug product" are often used synonymously, although there are some fundamental differences between them. We will point them out in the course of this article!

micheal-eder

Michael Eder

April 11, 2023

Recommended Downloads

E-Book

eBook: Filling Gaps in Managing Large Volumes of Biologics

Aseptic aliquotation and cryopreservation of drug substances are crucial process steps in bioprocessing. Even though they’re not in the spotlight of biomanufacturing. In drug development and drug delivery, biologics must be transferred at numerous occasions. Along the journey of monoclonal antibodies, vaccines and more, the drug substance passes lots of process steps where liquid transfer is required. This is relevant for the transitions between upstream processing, downstream processing and fill & finish, but also within these manufacturing milestones. The market of fluid & cold chain management has great growth potential and is on its way to professionalization and industrialization. To meet the challenges of manufacturing drug substances, Single Use Support helps manufacturers and CDMOs to advance their fluid & cold chain management process to achieve a secure and efficient process for liquids on the basis of single-use bags.

E-Book

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes

E-Book

Whitepaper: Automated Aseptic Filling

Read our Whitepaper about Automated Aseptic Filling in Pharmaceutical Manufacturing | Discover why automatic filling solutions are preferable to manual filling.