Process Insights

Most bulk drug substances are filled into 2D single-use bags for one reason: they are about to be frozen. Yet filling and freezing are often treated as separate unit operations. Filling systems are selected for accuracy and throughput. Freeze-thaw...

How is your frozen drug substance moving through the facility?  While freezing performance and storage temperature often receive the most attention, day-to-day efficiency depends on what happens between those steps. Every loading, transfer, and...

As batch sizes for bulk drug substances continue to grow, many biopharmaceutical facilities are reaching the limits of their existing freezing and storage infrastructure. At first glance, this appears to be a capacity issue, but in reality, it oft...

Biopharmaceutical manufacturing has undergone a shift toward higher production volumes, more diversified modalities, and more flexible production models. Despite these new demands for handling varying batch sizes and customer-specific requireme...

One could read a lot about single-use bags in biopharmaceutical industry as a primary packaging in bioprocessing in the previous last years. The rise of bags has become more relevant, since they largely replaced single-use bottles. Nevertheless, s...

With the rising need for novel therapies - and, based on the changes in the disease landscape as most currently highlighted by COVID - the global biopharmaceutical industry is evolving, and market needs are shifting. We are seeing an increasing...

Upstream process intensification is something you currently hear a lot in the context of upstream bioprocessing (USP) optimization. One of the upstream intensification processes being addressed is seed train intensification. This is the use of ...

Seed train intensification is an approach in upstream bioprocessing that is gaining more and more attention. With the growing demand for new drugs, manufacturers have to ensure both efficient and flexible production processes. While generally a...

The concept of end-to-end solutions is transforming industries with a focus on seamless and efficient processes. For biopharmaceuticals this includes the drug substance handling with filling, freezing/thawing and transporting sensitive drug substa...

Khalil Essani, Product Line Manager at Single Use Support, is an expert in bioprocessing applications for single-use technologies. He provides valuable insights, advantages and solutions using cell banking in seed train intensification in the f...

Microbial and mammalian cell fermentation are important processes in the development of media and drug development for the production of biologics, most importantly vaccines. However, there are certain characteristics that differentiate them from ...

Biopharmaceutical processing is an integral part of the life sciences, biotech and pharmaceutical industries. The associated market for biopharmaceutical manufacturing equipment and consumables is expected to grow with a double-digit CAGR for the ...