• Image of RoSS.pFTU Large-Scale for controlled freezing and thawing of larger volumes of drug substances, on a transparent background.

Plate freeze-thaw platform | RoSS.pFTU Large-Scale

Plate freeze-thaw platform | RoSS.pFTU Large-Scale

Single Use Support's large scale system is a plate-based freeze-thaw unit for any scale and batch size. The system is compatible with single-use bags of all sizes and manufacturers and enables a controlled process down to -80°C of up to 400L per batch.  

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Down to -80°C
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Available to Lease
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Up to 400L+/Batch

Features and benefits of RoSS.pFTU Large Scale

  • Enables controlled freezing down to -80 °C with highest possible speed and accuracy
  • Capacity of up to 400L, depending on bag type
  • Single-use bag independent: any bag vendor, any size
  • Best product stability results for mABs and BDS
  • Fully automated and ready for cGMP use
  • Combination with RoSS® shells for optimal protection and handling of single-use bags during freezing
  • Standard configurations are available with short lead times to support accelerated project timelines.

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Advantages of controlled rate plate freezers

  • Graphic of two frozen single-use bags showing different freezing results

  • To demonstrate the effects of cryoconcentration, Naphthol Blue Black was used as a visual marker. The intensity of the blue coloration indicates the concentration of dissolved substances within the frozen solution.

    Slow uncontrolled freezing (A)

    In contrast, bags frozen in a static freezer show uneven solute distribution. Dark blue areas, especially in the lower regions of the bag, highlight significant cryoconcentration.


    Fast controlled freezing (B)

    Bags frozen using our plate-based controlled rate freezer show a uniform distribution of solutes. The result is a consistent, light-blue hue with a distinct white line through the center indicating minimal cryoconcentration.

Downloads

Preview of datasheet for RoSS.pFTU Large Scale freeze-thaw unit by Single Use Support
RoSS.pFTU Large Scale - Datasheet
Preview of datasheet for RoSS.pFTU Large Scale freeze-thaw unit by Single Use Support
RoSS.pFTU Large Scale - Datasheet
 
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
RoSS.pFTU - Controlled scalable freezing - Whitepaper
Preview of Single Use Support's whitepaper about controlled freezing with RoSS.pFTU
RoSS.pFTU - Controlled scalable freezing - Whitepaper
 
Preview of Single Use Support's study about scalable freezing
Scalable freezing of protein-based biologics - Study
Preview of Single Use Support's study about scalable freezing
Scalable freezing of protein-based biologics - Study
 

Scalable freeze-thaw platforms

  • Single Use Support platforms provide insular solutions for the freeze/thaw processes of each clinical phase. Fully scalable and compatible with all batch sizes and bags from all established manufacturers – you will only require one single system from the lab to blockbuster production. From 10mL up to 50L bags and a batch size of up to 500L and more you can scale-up or down as required.

    More information
  • Graphic of different scale-up stages for freeze-thaw systems used in biopharmaceutical manufacturing.

More solutions

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