Future-proof your biologics cold chain

End-to-end solutions for biopharma cold chain processes

Single Use Support empowers biopharma companies with cold chain solutions that ensure uncompromised product integrity from lab to large-scale manufacturing. Our advanced solutions safeguard valuable drug substances through controlled freezing, secure storage, and reliable thawing.

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Control freezing & thawing
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Minimize product loss
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Scale production capacity

Challenges in biopharma cold chain management

  • Compliance: Validated, controlled and documented freeze–thaw processes support GMP‑aligned contamination control and data integrity requirements.
  • Product quality: Uncontrolled freezing can compromise critical quality attributes, leading to instability, cryoconcentration, and loss of product integrity.
  • Scalability: Biologics manufacturers must scale from clinical phases to commercial production without compromising quality.

    Solutions for your entire biologics cold chain

    • Infographic of cold chain management methods solutions including primary & secondary packaging, freeze & thaw, ultra cold storage, and cold chain shipping.

    Why to choose Single Use Support

    • A top-view image of a frozen single-use bioprocess container protected by a RoSS Shell.

      Minimized product loss

      Single Use Support’s solutions ensure the integrity of drug substances throughout the entire cold chain – delivering GMP readiness and reducing product loss.

    • Mid-frame image of two pharmaceutical blast freezers by Single Use Support.

      Vendor-agnostic

      Our solutions are designed to work seamlessly with bags and bottles from all leading providers – giving you flexibility without compromise.

    • Mid-frame image of an operator using RoSS.pFTU Lab-Scale freezer for controlled freezing of cells or monoclonal antibodies (mAbs).

      Scalable

      Scale up and out while maintaining maximum product quality. A range of solutions for bags and bottles supports manufacturers from lab to blockbuster production.

    Our customers trust in us:

    Rentschler Biopharma
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    Static versus plate-freezing biologics

    Preview of Single Use Support's study about scalable freezing

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    Study: Scalable freezing of protein-based biologics

    In collaboration with Single Use Support, the Zürich University of Applied Sciences conducted a series of studies to explore how different freezing technologies and controlled freezing and thawing rates affect product quality. Results show experimental insights into cryoconcentration, protein stability, and the impact of freezing rates - highlighting how Single Use Support’s plate-based freeze-thaw platform ensures product integrity and process scalability.

    Study: Scalable freezing of protein-based biologics
     

    More information

    Sustainable freezing in biopharma: Emerging trends & the role of natural gas

    Sustainable freezing in biopharma: Emerging trends & the role of natural gas

    There will continue to be an ongoing need for cryopreservation and cold chain management of drug substances. However, these processes will no longer depend on F-Gases.  The utilization of F-gases, also known as fluorinated greenhouse gases, is ste...

    Alexander Fuchs
    Alexander Fuchs
    Freezing and cold chain solutions for biologics – best practices

    Freezing and cold chain solutions for biologics – best practices

    Freezing biologics is an almost unavoidable step in the process of preserving and storing them for an extended period of time. After all, biologics encompass a diverse range of therapeutic products derived from living organisms. They include mo...

    Alexander Fuchs
    Alexander Fuchs
    Freeze-Thaw Platforms Defying Cryoconcentration

    Freeze-Thaw Platforms Defying Cryoconcentration

    Freezing and thawing drug substances involve the use of both primary packaging, single-use bioprocess containers and bottles, the latter also known as rigid containers or PE containers. Biopharmaceutical manufacturers and CMOs typically require...

    Alexander Fuchs
    Alexander Fuchs

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