Advanced fluid & cold chain management of bottles

Blast Freezing Bottles - Single Use Support

From clinical to commercial without compromise

Single Use Support’s bottle solutions ensure safe, scalable handling of drug substance, media, and buffers. From closed-system filling to controlled freezing and validated protection, we help you secure every drop.

Control bottle freezing
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Increase process efficiency
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Stop contamination
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Control freezing & thawing

Challenges in bottle-based workflows in biopharma:

  • Filling: Open systems and manual handling increase the risk of contamination and bioburden.
  • Freezing: Uncontrolled freezing leads to product instability and container damage from leakage or breakage.
  • Bottle breakages: Unprotected containers are prone to leakage or breakage, compromising product integrity.
  • End-to-end processes: Manual and fragmented workflows limit scalability and consistency across clinical and commercial stages.

    Scalable solutions for your bottle processes

    • Person in a lab coat overserving an automated fill run of bottles with RoSS.FILL Bottle

      Fast & homogeneous aliquoting

      RoSS.FILL Bottle: Automated aseptic filling platforms to enable accurate, fast and safe dispensing into bottles. Introducing 21 CFR Part 11 and GMP-compliance paired with high filling accuracy help advance fluid management processes.

      IRIS single-use assemblies are customized off-the-shelf fluid transfer tubing sets to provide an aseptically closed system and qualified bottle fluid path.

    • Mid-frame image of two pharmaceutical blast freezers by Single Use Support.

      Controlled freezing & thawing

      RoSS.BLST is a GMP-compliant system for blast freezing & thawing of drug substances. It is suitable for any primary packaging from all manufacturers and allows freezing and thawing within a temperature range of -80°C to +40°C.

      The modular and mobile internal rack system offers maximal flexibility and enables a simple transfer from blast freezing to ultra-cold storage.

    • Close-up image of a frozen Bottle RoSS by Single Use Support, shown on a white background.

      Best container integrity

      Bottle RoSS protects the tubing on bottles protected at glass-like sub-zero temperatures with the help of a soft 3D foam which hardens at frozen state.

      Any manufacturer of rigid containers from 500mL to 10L can be protected with Bottle RoSS. Its dimensions incl. height is adjustable according to tubing/connectors attached upon request.

    Our customers trust in us:

    Rentschler Biopharma
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    Reference Logo

    Preview whitepaper controlled blast freezing of bulk-packaged DS - Single Use Support

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    Controlled blast freezing for bulk-packaged drug substance

    Freezing drug substances in bottles can be challenging, especially when it leads to product instability or cryoconcentration. Controlled blast freezing is key to preserving product quality. But efficient drug manufacturing requires more: Container closure integrity, smart use of facility space, sustainability and process flexibility are essential for scaling and streamlining operations. Read on to explore what really matters when freezing bottles.

    Controlled blast freezing for bulk-packaged drug substance
     

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    Freezing bottles – 5 critical considerations

    Freezing bottles – 5 critical considerations

    Freezing drug substances to ultra-cold temperatures is a standard step in biopharmaceutical manufacturing. Yet, beyond simply cooling, it’s the critical quality attributes (CQA), like product safety, consistency, and process efficiency, that trul...

    Claus Exenberger
    Claus Exenberger
    How blast freezing affects the quality of bottled drug substance: Test results and insights

    How blast freezing affects the quality of bottled drug substance: Test results and insights

    For some time now, scientists have been discussing the challenges associated with freezing biopharmaceuticals in sterile bottles – especially the risk of cryoconcentration and how it might affect product quality. So, we decided to take a closer l...

    Claus Exenberger
    Claus Exenberger
    Blast freezer in biopharma: What, when and why?

    Blast freezer in biopharma: What, when and why?

    Blast freezers have emerged as a reliable solution in the biopharmaceutical industry. However, pharmaceutical bulk freezing is not just about turning liquids into solids; it is also about preserving the integrity and quality of life-saving drug s...

    Michael Eder
    Michael Eder
    Preview of Single Use Support's case study about automating the process of filling media into bottles

    Download Case Study

    Case Study: Automating the process of filling media into bottles

    A biopharmaceutical manufacturer based in Latin America used single-use bottles and 3D bags for aseptic media filling. The switch from manual to automated filling of media into single-use bottles of varying sizes and volumes has markedly improved operational efficiency. Read the case study to learn more about the potential savings and efficiencies.

    Case Study: Automating the process of filling media into bottles
     

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    Sterile bottles trends in Biopharma

    Interview: Trends with Single-Use Bottles in Bioprocessing

    One could read a lot about single-use bags in biopharmaceutical industry as a primary packaging in bioprocessing in the previous last years. The rise of bags has become more relevant, since they largely replaced single-use bottles. Nevertheless, s...

    Khalil Essani
    Khalil Essani
    From carboys to rigid containers: what are the top single-use bottles in biopharma today?

    From carboys to rigid containers: what are the top single-use bottles in biopharma today?

    Despite the popularity of single-use bags for primary packaging, single-use bottles remain critical for storing, transferring, and sampling media, buffers, and drug substances throughout the biomanufacturing workflow. These sterile, reliable, and ...

    David Seifert
    David Seifert
    An operator’s burden: Why manual bottle filling puts biomanufacturers at risk

    An operator’s burden: Why manual bottle filling puts biomanufacturers at risk

    The hidden risk in biomanufacturing Manual bottle filling in biopharmaceutical production is more than a routine task - it’s a high-stakes responsibility. From upstream cell culture to downstream purification, every step is tightly controlled - un...

    Jonathan Haider
    Jonathan Haider

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