One could read a lot about single-use bags in biopharmaceutical industry as a primary packaging in bioprocessing in the previous last years. The rise of bags has become more relevant, since they largely replaced single-use bottles. Nevertheless, s...
Microbial and bacterial fermentation is of great importance in the production of biologics, especially for the manufacturing of small molecules. The filling and freezing of large volumes for fermentation is an essential part during different produ...
Pharmaceutical fermentation is a multi-stage process that not only facilitates high-cell density, but also a high yield in terms of final culture generation. Whether the final product requires microbial fermentation or the fermentation of mammalia...
Precision fermentation uses microbial hosts to produce a particular end product. Other terms used for precision fermentation are bacterial and microbial fermentation. Precision fermentation is used in a variety of ways in both the food industry an...
Microbial fermentation refers to the production of microbial products, which can be enzymes, vaccines or other drugs, by the use of microorganisms. For this process, compliance with cGMP (Current Good Manufacturing Practice,) and the FDA’s regulat...
The fact that the pharmaceutical manufacturing process, including pharmaceutical fermentation, is still prone to human error and product loss can be more than frustrating. This is even more true when dealing with issues that are near and dear to y...
While the original definition of fermentation is ‘the anaerobic conversion of sugar to carbon dioxide and alcohol by yeast”, fermentation in the pharmaceutical industry is used to cultivate microorganisms for antibiotics, therapeutic proteins, enz...
The manufacturing process of biopharmaceuticals such as monoclonal antibodies, mRNA and bioconjugates is divided into upstream and downstream processing. Manufacturers seeking reliable automation and optimization fit for scale-up are increasing...
One would think that a sector like the fast-paced biomanufacturing industry could not get any faster. Yet, increased speed-to-market and ever more efficient manufacturing continue to drive product and process development. This is why single-use...
Upstream and downstream processing are two steps inherent to the production of active pharmaceutical ingredients (API) used in biopharmaceuticals. Upstream processing takes small quantities of engineered microbial or mammalian cell culture to g...
Single-use bioprocessing has recently experienced tremendous growth in biopharmaceutical manufacturing market share and enjoyed technological advances ranging from material properties, to implementation of Industry 4.0. In contrast to traditional ...
Cell monolayers are an ideal method and widely used in the discovery of new drug compounds and the study of cell biology. Until now, there was no cryopreservation technology available to store cell banks pre-plated commercially. The conventional a...
The processes of cryogenic freezing and cryopreservation are considered essential in biotechnology for the conservation of biomaterials. Regenerative medicine and other disciplines in life sciences were allowed to make huge leaps in the treatment ...
