Freezing drug substances to ultra-cold temperatures is a standard step in biopharmaceutical manufacturing. Yet, beyond simply cooling, it’s the critical quality attributes (CQA), like product safety, consistency, and process efficiency, that trul...
For some time now, scientists have been discussing the challenges associated with freezing biopharmaceuticals in sterile bottles – especially the risk of cryoconcentration and how it might affect product quality. So, we decided to take a closer l...
Blast freezers have emerged as a reliable solution in the biopharmaceutical industry. However, pharmaceutical bulk freezing is not just about turning liquids into solids; it is also about preserving the integrity and quality of life-saving drug s...
Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation in flat primary packaging, such as single-use bags. Things ...
What is DMSO? DMSO, or dimethyl sulfoxide, is a colorless liquid that is used for cell preservation. Thanks to its unique properties, it has found its way into laboratories worldwide. DMSO plays a vital role in protecting cells when temperatures d...
State-of-the-Art Freeze/Thaw System Donated to NIBRT The National Institute for Bioprocessing Research and Training (NIBRT) announced in April 2024 the receipt of a donation of Single Use Support's Lab Scale freeze/thaw system. The collaboration b...
At the beginning of drug discovery you always deal with small volumes. Handling the cooling of drug substances in small quantities may seem straightforward, yet the intricacies involved are often more complex than anticipated. Traditionally, the u...
Biopharmaceutical products are valuable and often highly sensitive substances. Their active pharmaceutical ingredients (APIs) must be maintained at the highest-possible quality at all times during their production, transport, and storage. This req...
Among the key innovations of the biopharmaceutical industry over recent decades, the cryovessel stands out as a critical component in the process of freezing biopharmaceuticals. In this blog post, we delve into the background of cryovessels and th...
Unlocking Potential: From outdated CryoVessels to state-of-the-art Plate Freezers The freezing method with multi-use cryogenic containers, also called cryovessels, has been used for decades. The open stainless-steel container is still largely in u...
The number of cold storage freezers for the biopharmaceutical market is countless. Some neither fulfill requirements of Big Pharma nor preferences for small biotechs. If you seek for a comparison in the myriad of options and promises with regards ...
Valuable bulk biopharmaceutical intermediates, such as bacterial or yeast cells in microbial fermentation or other intermediates produced during the manufacturing process of biopharmaceutical drugs, are often transported between different manufact...
