Freezing drug substances to ultra-cold temperatures is a standard step in biopharmaceutical manufacturing. Yet, beyond simply cooling, it’s the critical quality attributes (CQA), like product safety, consistency, and process efficiency, that trul...
Lipid nanoparticles (LNPs) have gained significant attention in nanomedicine as effective delivery systems for various therapeutics, including mRNA-based vaccines and gene therapies. LNPs offer advantages such as efficient encapsulation, target...
LNPs are used in various applications in medicine and other life sciences, e.g. as non-viral vectors for mRNA. However, lipid nanoparticle toxicity is a topic that needs to be addressed more closely. The structure of lipid nanoparticles and rea...
Lipid nanoparticles is about to change the pharmaceutical industry in their role as very efficient drug delivery systems, but shown advantages to different fields, like cosmetics, agriculture and other areas. Even though they are already succes...
New advances in mRNA technology are happening regularly and rapidly. The prevention and treatment of viruses and immunogenic diseases has become possible through new therapeutics that use messenger RNA to help the body produce the right proteins. ...
Gene therapy, a groundbreaking approach in modern medicine, holds immense promise for the treatment of various genetic diseases and cancer types. Central to the success of gene therapy are the vectors used to deliver therapeutic genes like mRNA...
In the realm of nanomedicine, lipid nanoparticles (LNPs) have emerged as versatile delivery vehicles, revolutionizing drug delivery and biomedical research. LNPs (liposomes and nanostructured lipid carriers) are at the forefront of nanotechnology ...
The number of cold storage freezers for the biopharmaceutical market is countless. Some neither fulfill requirements of Big Pharma nor preferences for small biotechs. If you seek for a comparison in the myriad of options and promises with regards ...
ADCs can be described as a new rising star among biopharmaceutics. They are able to specifically target and destroy cancer cells very effectively. Their levels of toxicity can vary depending on several factors, including their specific design and ...
Bioconjugates have proven to be very useful in the production of therapeutic drugs, diagnostics and research. Bioconjugate manufacturing, therefore, has enabled new advances in biochemistry. In this article, we will explain the basics of bioconjug...
Antibody-drug conjugates (ADCs) are a promising class of targeted cancer therapies that use monoclonal antibodies (mAbs) to selectively deliver potent cytotoxic drugs (cytotoxic agents) to cancer cells. With their ability to reduce systemic toxici...
ADC technology is a promising and exciting new approach in cancer treatment, selectively targeting a specific cell surface receptor expressed on cancer cells. With oncology being a main field of application, a number of preclinical tests for treat...
The safe handling of ADCs or other HPAPIs is a complex and elaborate process that requires specialized facilities and a safe, sterile environment. The filling/aliquoting step in particular calls for great care and specific equipment to ensure ster...
