Taking the shortcut in biopharma upstream manufacturing process!
SEED.STREAM by Single Use Support describes the next generation of cell culture intensification - the process of how to intensify the inoculation and seed train in the so-called Upstream of biopharmaceutical manufacturers at any scale by means of technologies by Single Use Support. This process includes end-to-end qualification.
At the very early stage of biopharma drug substance manufacturing, the upstream, cells are being nurtured from 1 ml to more than 2000 liters within approx. 5 weeks. There are many potential pitfalls in terms of sterility and appropriate cell perfusion when it comes to growing cell lines to their full potential.
Seed train intensification is a way to circumvent the continuous “back to start” with 1 ml and to benefit from the already expanded cells into bioreactors.
And this is where the SEED.STREAM, the next generation of seed train intensification, comes into play.
The very fragile cells need advanced automation, process control and high cell density cryopreservation in order to
If you want to be on the safe side when growing a beautiful flower, you’d also plant seedlings instead of casting seeds.
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