The final step in biopharmaceutical manufacturing is known as aseptic Fill & Finish. The final drug product is filled into vials, (pre-filled) syringes or single-use bags before it is ready for its distribution globally.
At this stage the liquid product is of the greatest value and this is one of the most critical steps. Any product that is contaminated or packaged incorrectly can result in safety issues, production failure and loss of valuable product. Therefore, maintaining sterility and quality of the final drug product is of utmost importance.
Mostly fully automated and highly sensitive processes are used for efficient product formulation and filling into vials and syringes. Prior to final filling at the Fill & Finish site, single-use applications ensure the safe and sterile receipt of drug products at frozen or cooled state. Various single-use technologies come into play for reliable biopharmaceuticals handling:
No matter if upon customized request or off-the-shelf, single-use assemblies can be assembled to ensure tailored fluid flow. Also at Fill & Finish production lines the product undergoes different process steps during fluid management, be it in isolators, filters, shakers or other final process steps. For small scale fill finish pre-filled syringes can be attached to the sterilized assembly. Single Use Support helps you to build your single-use assembly by means of its online configurator or direct inquries.
