Controlled Rate Freezing of Drug Substances | RoSS.pFTU Mid-Scale

Our mid scale freezer is a plate-based Freeze Thaw system. This unit designed to protect your preferred single-use bag during cryogenic applications. 

RoSS.pFTU mid scale is compatible with single-use bioprocess containers of all sizes and manufacturers and shows the best product stability results for your drug substances up to 100L. 

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temperature-control

Down to -80°C

controlled-freezing-thawing

Controlled rate freezing & thawing

capacity

Up to 100L

Advantages of controlled rate plate freezers

Dark blue spots indicate a higher cryoconcentration. 
Fast & controlled freezing with a plate freezer enables a homogeneous freezing result.

Advantages of controlled plate-freezers-Grafik

Features and benefits of drug substance freezer RoSS.pFTU Mid-Scale

Plate-based Freeze and Thaw Unit for freezing and thawing of drug substances protected by RoSS shells from Single Use Support:

  • Capacity up to 5 bags of 20L each, depending on bag type
  • Usage for stability studies in labs and small batch sizes
  • Single-Use Bag independent: any bag vendor, any size
  • Recommended to protect your single-use bag with RoSS shells at your freeze/thaw unit
  • Up to 100L load with different sizes of single-use bags
  • Best product stability results for mABs and BDS
  • GMP-compliant, automated, at highest possible speed and accuracy
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Advancements in Small Volumes Drug Freezing Techniques

RoSS.pFTU Mid Scale_In Process-4

Advancements in Small Volumes Drug Freezing Techniques

Freezing small volumes extends beyond laboratory settings to include commercialized manufacturing processes for small batches in biomanufacturing, like cell banking, gene therapies utilizing viral vectors, lipid nanoparticles, and fill & finish procedures.

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Our customers trust in us:

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Rentschler Biopharma SE

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SCHOTT Pharma

Data sheets

Datasheet_pFTU_MidScale

Datasheet RoSS.pFTU Mid Scale

Filesize: 0.57 MB – Mime-Type: application/pdf

Scalability Guide RoSS.pFTU

Freeze & Thaw Scalability Guide

Filesize: 0.83 MB – Mime-Type: application/pdf

Whitepaper_Controlled_Scalable_Freezing

Whitepaper: How Controlled & Scalable Freezing Becomes Reality

Filesize: 1.77 MB – Mime-Type: application/pdf

More solutions

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RoSS.pFTU Lab-Scale | Plate Freeze & Thaw

1mL-10L: Laboratory freezer, compatible with single use bags of all sizes and manufacturers. Our lab freezer is the perfect solution for studies conducted in labs and, above all, if you want to start a controlled and scalable freezing process.

Down to -80°C
Up to 10L
Controlled rate freezing & thawing
More information
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RoSS.pFTU Large-Scale | Plate Freeze & Thaw

Up to 400L: Our large scale freezing platform system is a plate-based pharmaceutical freeze and thaw unit. The system enables controlled rate freezing and is compatible with single-use bags of all sizes and manufacturers.

Down to -80°C
Up to 400L
Controlled rate freezing & thawing
More information
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RoSS.ULTF | Ultra-low Temperature Storage Freezer

RoSS.ULTF is an ultra-low temperature storage fridge for frozen drug substances in different sizes. The ULT storage freezer keeps the desired set point temperature down to -80°C. RoSS.ULTF offers highest storage density, is fully movable and can be modularly adapted to your individual needs.

Down to -80°C
Capacity for up to 300L
Modular Interior
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ross-shak-shaker

ROSS.SHAK | Shaker

RoSS.SHAK is your reliable shaker to regain highest quality and homogeneity of your biopharmaceuticals.

RoSS.SHAK enables constant shaking of your protein to regain homogeneity and product quality after freezing. Shakes up to 70L per run in 3 pre-defined speeds.

Product homogeneity
Up to 100L per run
Up to 20L bags
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RoSS.PADL | Homogenizing Solution

RoSS.PADL is a scalable massaging platform for achieving a uniform mixture in single-use bags. With integrated cooling and heating, it maintains optimal temperatures consistently.

Bag Independent
Consistent Homogeneity
Temperature Control
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RoSS.LN2F | Cryogenic Freezer

RoSS.LN2F is a powerful cryogenic controlled rate freezer for temperatures down to -170°C. An enclosed LN2 system and our innovative direct injection system ensure no direct exposure and no mechanical compressors are needed. This ensures a safe, low-maintenance and energy-saving handling.

Down to -170°C
Increased Cell Viability
Down to < 250mL/ Bag
More information

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Single-use technology

Single-use Technology

Single-use technology & the implementation in biopharma

Single-use technologies, which reduce the risk of cross-contamination of high-quality bulk drug substances, are becoming increasingly popular in the pharmaceutical industry. You can find out the reason for this in the blog post!
 

micheal-eder

Michael Eder

April 30, 2020

Freeze-thaw technology for handlings mAbs on another quality level

Monoclonal Antibodies

Evaluating freeze-thaw processes in antibody production

In a field as sensitive as monoclonal antibody development and production, controlled processes and procedures have always played a vital role and will continue to do so. Learn more why Single-use technologies are highly flexible, scalable and on another quality level.

Alexander Fuchs | Single Use Support

Alexander Fuchs

December 11, 2023

Single-Use-Support-Controlled-Freezing-Biopharmaceuticals

Freeze & Thaw

Whitepaper: How controlled freezing enables scalability

In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.

micheal-eder

Michael Eder

February 15, 2022

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