Compatible with single use bags of all sizes and manufacturers. Our lab scale freezer is the perfect solution for studies conducted in labs and, above all, if you want to start a controlled and scalable freezing process.
January 20, 2020
Biopharmaceutical manufacturers are increasingly utilizing single use technologies for cold storage, shipping in the cryogenic temperature range and the transfer of biopharmaceutical substances and reagents under strict temperature control. The advantages speak for themselves:
By abandoning cost-intensive, outdated, and bulky lab equipment such as auto defrost solid door upright freezers, conventional manual defrost chest freezers, and ultra-low temperature freezers, manufacturers can save considerable amounts of USD and increase productivity considerably for each cu ft of plant space.
Single use technologies, and single-use bioprocess containers in particular, require little storage space, which makes them a cost-effective solution. Additionally, bags of different sizes are freely available on the market and, where required, established and standardized quality tests are available to be conducted before filling and use.
Recently, the COVID-19 pandemic highlighted a weak point in the life science and biopharma business: refrigeration, freezing and cold temperature technology in general. With the need to manufacture massive amounts of vaccine vials with unprecedented storage requirements, the bottleneck of vaccine storage and transport emerged. This situation challenged innovative companies to develop benchtop solutions to overcome lab refrigerators and freezers.
But the advantages of single use technology do not end with the storage: The entire handling of the logistics process for biopharmaceutical liquids is fool-proof, especially when compared to the utilization of stainless-steel tanks, Cryo vessels and other traditionell alternatives. With the use of single use technologies, cleaning, storage as well as complicated logistics can practically be omitted.
Where the water volume as well as chemical detergents required when using stainless-steel solutions are significant and far from being sustainable, single use technology is leading the way in terms of sustainability.
All these factors apply to established manufacturing as well as the production of small batches conducted in labs or for study purposes with conventional methods such as chromatography, countertop centrifuges, PCR, pipettes, and electrophoresis.
Humans are simple beings. So it seems just plausible to use a general purpose compressor fridge or laboratory freezer for freezing liquids such as culture media. But things are not always as simple as they may appear. While the use of laboratory refrigerators and low freezers may be logical, the outcome is far from the optimum and usually unsatisfactory. Traditional defrost freezers have disadvantages that can be clearly measured:
At first it may feel unfamiliar to place a microplate or filled single use bag in a compact plate freezer, which seems to resemble a toaster rather than a freezing device.
However, appearances don’t matter as long as the outcome doesn’t fail to convince:
The construction and functionality of a plate freezer for lab use is demonstrated in this video. The filled single use bag is integrated in the RoSS Shell System specifically developed by Single Use Support to offer protection and security against manipulation, while at the same time facilitating an ideal temperature transfer for the freeze/thaw process in plate freezers.
The advantages of single use bags and the entire single use technology for labs are evident: Single use technology is financially attractive, flexible and easy to handle, yet it offers the highest degree of system compatibility in terms of partner and manufacturer interfaces as well as the internationalization of processes.
At some point in time any successfully tested product will outgrow the lab. It is ready for market – but what now? Do all processes need to be newly scaled? Do all platforms need to be newly validated?
Single Use Support simply says: NO
If required, a lab-scale platform can be upscaled to small-scale and to blockbuster production without having to newly define processes or obtain FDA and other validations – either for one or across several sites.
If you had to illustrate a sustainable and smooth, scalable process for a new biopharmaceutical product, RoSS.pFTU lab scale would be the only viable solution.
What is more, Single Use Support’s lab scale also offers a compact freeze-thaw system for rent.
Conclusion: All advantages speak for themselves. Single use technology is clearly on the rise. The system is scalable and the initial costs can be lowered further with our rental option. Compared with lab freezer costs when buying equipment or lab freezer rental, Single Use Support’s seamlessly scalable freeze/thaw platform is simply more cost-effective and an alluring option. It does not require any further validations for an upgrade of batch sizes.