Controlled freezing and thawing of large volumes in biopharmaceutical manufacturing processes. The extra large scale freezing platform system is an automated plate-based freeze-thaw unit for 500 liters per batch of liquid substances including vaccines, media, buffer solutions or other drug substances. The established RoSS.pFTU platform system is compatible with 10x50L single-use bags from any vendor.
Advantages of controlled rate plate freezers for bulk drug substances
Dark blue spots indicate a higher cryoconcentration.
Fast & controlled freezing with a plate freezer enables a homogeneous freezing result.
Features and benefits of RoSS.pFTU XL
Plate-based freeze & thaw platform system for controlled freezing and thawing of extra large volumes and bulk drug substances (BDS) in biopharma manufacturing processes:
- Capacity: 500L nominal volume per Batch (10x50L Bags)
- Flexible primary packaging: Choose any 50L single-use bag of your choice
- Freezes down to -80°C
- Thawing with integrated shaker function
- Technology: Plate-based freezer for homogeneous freezing of your product
- GMP-compliant, automated, at highest possible speed and accuracy
RoSS Shell for Protection & Secondary Packaging of bulk drug substances
- For best protection and optimized homogeneous freezing we recommend the use of RoSS shells for your single-use bags
- Simple loading and unloading of the RoSS shells with a specific external rack
- Direct contact between RoSS shells and thermoplate enables a controlled and rapid freeze-thaw process
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Advantages of RoSS.pFTU over other solutions in the industry
Cryovessel platform 1 | Blast-freezer platform 2 | Plate-based freeze thaw platform RoSS.PFTU XL | Comments | |
| Fast freezing | × | × | ✅ | The RoSS.pFTU XL achieves controlled freezing to -80°C in less than 10 hours |
| Vendor-agnostic primary packaging | ⁓ | × | ✅ | Full freedom on choice of your primary packaging supplier to ensure a closed system |
| Modularity & scalability | × | × | ✅ | Scalable freezing with the RoSS.pFTU plate-freezers from 1L up 500L nominal volume per batch |
| Minimum manual handling | ⁓ | ⁓ | ✅ | Fully automated freezing process & simple loading/unloading with a specific external rack |
| Product viability | × | × | ✅ | Higher product quality with controlled plate-freezing preventing the effect of cryoconcentration |
The ROI of bulk production freezing with controlled plate freezers
The switch from cryovessels to plate-based freeze & thaw single-use technologies is, not least, a matter of costs. To determine the return on investment (ROI), different cost drivers were identified and evaluated. Discover the comparison of cryovessels, blast freezers and plate-based freezers in this case study.
