Khalil Essani

Protein production is a crucial process that which a large variety of pharmaceutical products rely on. Therefore, we will discuss this procedure in this article, along with possibilities to improve it.

Protein stability is crucial to be maintained along the manufacturing process of protein-based products. In this article, we will discover what influences protein stability, along with methods to assess and increase it.

Khalil Essani, Product Line Manager at Single Use Support, is an expert in bioprocessing applications for single-use technologies. He provides valuable insights in the use of cell banking in seed train intensification.

Annex 1 and PUPSIT meant significant changes in the pharmaceutical sector. In this article, we will illustrate the focus areas of Annex 1 and will discuss main aspects of PUPSIT.

There are various approaches to validate the integrity of sterile filters, as is required by several regulatory frameworks. We will cover some of the most common methods in this article.

Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.

The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).

From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production. 

Several trends are re-shaping monoclonal antibody manufacturing – from the minimized use of in vivo practices to the implementation of automated processes. In this article, we will highlight 5 current trends in mAb manufacturing.

The monoclonal antibody manufacturing process is an essential cornerstone in research as well as in the production of diagnostic and therapeutic tools. Therefore, we will take a closer look at how mAbs are made – in this article.

Single-use technologies bring several advantages to vaccine production, from fluid management to cold chain measures. We will uncover the most important benefits of SUT for this sector in this article.

When designing gene therapies, the choice between non-viral and viral vectors plays an important role in determining the success and safety of therapeutic interventions. Non-viral vectors offer unique advantages, while viral vectors have their own set of strengths and weaknesses. In this blog post, we will explore the types, benefits, and limitations of both non-viral and viral vectors in gene therapy.