Khalil Essani is Product Line Manager at Single Use Support. Scientist through and through he develops single-use technologies to further advance the biopharmaceutical industry during its shift towards single-use systems. Based on his extensive expertise and graduate in bioprocessing and biotechnology Khalil authors several publications. At Single Use Support he focuses on sterile products in the field of fluid and cold chain management.
Articles written by Khalil Essani
Cell & Gene Therapy
DMSO: Freezing Cells
Freezing cells is a process that requires more than simply placing them in a freezer with dimethyl sulfoxide (DMSO). It is a precise and meticulous process, where precision and expertise are essential. The goal is to achieve high cell viability and therefore high yield for cell-based therapies or cell banking.
Khalil Essani
October 11, 2024
Single-use Consumables
Go with The Flow: How Sustainable is the Trend Toward Single-use Systems?
Single-use systems support novel approaches to aseptic fluid management and aseptic liquid transfer. However, regarding the sustainability of single-use systems, there are still concerns within the scientific community. BioPharm International sat down with Single Use Support to address these apprehensions and discuss the future of single-use systems in biopharma.
Khalil Essani
February 5, 2024
End-to-end Solution
Protein production and optimization strategies
Protein production is a crucial process that which a large variety of pharmaceutical products rely on. Therefore, we will discuss this procedure in this article, along with possibilities to improve it.
Khalil Essani
April 9, 2024
End-to-end Solution
Protein stability – all you need to know
Protein stability is crucial to be maintained along the manufacturing process of protein-based products. In this article, we will discover what influences protein stability, along with methods to assess and increase it.
Khalil Essani
April 9, 2024
Cell Banking
Interview: Efficient Cell Banking in Seed Train Intensification
Khalil Essani, Product Line Manager at Single Use Support, is an expert in bioprocessing applications for single-use technologies. He provides valuable insights in the use of cell banking in seed train intensification.
Khalil Essani
April 4, 2024
Single-use Consumables
Annex 1 and the PUPSIT requirement
Annex 1 and PUPSIT meant significant changes in the pharmaceutical sector. In this article, we will illustrate the focus areas of Annex 1 and will discuss main aspects of PUPSIT.
Khalil Essani
March 13, 2024
Single-use Consumables
Overview of filter integrity testing methods
There are various approaches to validate the integrity of sterile filters, as is required by several regulatory frameworks. We will cover some of the most common methods in this article.
Khalil Essani
March 13, 2024
Cell & Gene Therapy
Regulations for Cryoprotectants in ATMP Cryopreservation
Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.
Khalil Essani
February 7, 2024
Cell & Gene Therapy
Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation
The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).
Khalil Essani
February 8, 2024
Monoclonal Antibodies
Steps in Monoclonal Antibody Production
From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production.
Khalil Essani
February 6, 2024
Monoclonal Antibodies
Trends in monoclonal antibody production: Optimizing processes with single-use technology
Several trends are re-shaping monoclonal antibody manufacturing – from the minimized use of in vivo practices to the implementation of automated processes. In this article, we will highlight 5 current trends in mAb manufacturing.
Khalil Essani
January 18, 2024
Monoclonal Antibodies
Monoclonal antibody production process: a comprehensive guide
The monoclonal antibody manufacturing process is an essential cornerstone in research as well as in the production of diagnostic and therapeutic tools. Therefore, we will take a closer look at how mAbs are made – in this article.
Khalil Essani
January 18, 2024