Michael Eder

What does "allogeneic" mean, precisely? How do allogeneic cell therapies work, and what is the difference to autologous approaches? Questions like these will be answered in this article.

The term "autologous" is most frequently found in the context of cell therapy. In this article, we will therefore take a closer look at this revolutionary therapeutic approach.

Since the first ADCs entered clinical trials in the 1990s, they have shown great promise in treating a variety of cancers and other diseases. However, the development of ADCs has also been marked by challenges and setbacks, including issues with efficacy, safety, and manufacturing. In this article, we will explore the history of ADCs, from their early development to the latest advances in technology and applications.

The terms "drug substance" and "drug product" are often used synonymously, although there are some fundamental differences between them. We will point them out in the course of this article!

When it comes to the filling process of drug substances, there several aspects to be considered to achieve high-quality results with as little product loss as possible. In this article, we will discuss 5 major threats for the filling of drug substances.

In this article, we will discuss the special requirements of biologicals in terms of packaging as well as efficiency and sustainability aspects of biopharma packaging.

Throughout the manufacturing process of drug substances, the liquids must be transferred frequently, such as during the upstream and downstream processing. Safe packaging of large volume substances is of high necessity in each step. Protection is ensured by appropriate primary and secondary packaging. This article will provide an overview of the different types of primary and secondary packaging materials, which are used specifically for safe handling of drug substance. 

For drug substances that undergo a freezing process during manufacturing, thawing at some point is only a logical consequence. However, there are several factors to be considered for this seemingly easy procedure – find out more in this article!

Filling accuracy has become increasingly important for laboratories and biopharmaceutical manufacturers. Single Use Support has developed best-in-class filling precision for aliquoting small single-use bags with its RoSS.FILL Lab Scale aseptic filling platform.

Fermentation has been with mankind at least since the first settlements in the Middle East about 12,000 years ago. Today, scientists have gained so much knowledge about microorganisms and the fermentation process that pharmaceutical manufacturers are using it for the production of vaccines or bioconjugates like ADCs (antibody-drug conjugates) and the development of advanced therapies.

Precision fermentation uses microbial hosts to produce a particular end product. Other terms used for precision fermentation are bacterial and microbial fermentation. 

Precision fermentation is used in a variety of ways in both the food industry and pharmaceutical industry to produce biopharmaceuticals. Read more!

Microbial fermentation is a biochemical process that manages to extract chemical energy from carbohydrates without the oxygen. 

This chemical reaction occurs in bacteria, yeasts or even in muscles of humans. Read more details!